Fabrication of Ceftriaxone-Loaded Cellulose Acetate and Polyvinyl Alcohol Nanofibers and Their Antibacterial Evaluation
Nanotechnology provides solutions by combining the fields of textiles and medicine to prevent infectious microbial spread. Our study aimed to evaluate the antimicrobial activity of nanofiber sheets incorporated with a well-known antibiotic, ceftriaxone. It is a third-generation antibiotic that belon...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/11/3/352 |
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| author | Youdhestar Faraz Khan Mahar Gotam Das Ayesha Tajammul Farooq Ahmed Muzamil Khatri Sheeraz Khan Zeeshan Khatri |
| author_facet | Youdhestar Faraz Khan Mahar Gotam Das Ayesha Tajammul Farooq Ahmed Muzamil Khatri Sheeraz Khan Zeeshan Khatri |
| author_sort | Youdhestar |
| collection | DOAJ |
| description | Nanotechnology provides solutions by combining the fields of textiles and medicine to prevent infectious microbial spread. Our study aimed to evaluate the antimicrobial activity of nanofiber sheets incorporated with a well-known antibiotic, ceftriaxone. It is a third-generation antibiotic that belongs to the cephalosporin group. Different percentages (0, 5%, 10%, 15%, and 20%; based on polymer wt%) of ceftriaxone were incorporated with a polymer such as polyvinyl alcohol (PVA) via electrospinning to fabricate nanofiber sheets. The Kirby-Bauer method was used to evaluate the antimicrobial susceptibility of the nanofiber sheets using <i>Escherichia coli</i> (<i>E. coli</i>) and <i>Staphylococcus aureus</i> (<i>S. aureus</i>). For the characterization of the nanofiber sheets incorporated with the drug, several techniques were used, such as Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and scanning electron microscopy (SEM). Our results showed that the nanofiber sheets containing ceftriaxone had potential inhibitory activity against <i>E. coli</i> and <i>S. aureus</i> as they had inhibition zones of approximately 20–25 mm on Mueller-Hinton-agar-containing plates. In conclusion, our nanofiber sheets fabricated with ceftriaxone have potential inhibitory effects against bacteria and can be used as a dressing to treat wounds in hospitals and for other biomedical applications. |
| first_indexed | 2024-03-09T20:12:16Z |
| format | Article |
| id | doaj.art-0979914fd9474b25b61704e7ce14d02b |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-09T20:12:16Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-0979914fd9474b25b61704e7ce14d02b2023-11-24T00:11:09ZengMDPI AGAntibiotics2079-63822022-03-0111335210.3390/antibiotics11030352Fabrication of Ceftriaxone-Loaded Cellulose Acetate and Polyvinyl Alcohol Nanofibers and Their Antibacterial EvaluationYoudhestar0Faraz Khan Mahar1Gotam Das2Ayesha Tajammul3Farooq Ahmed4Muzamil Khatri5Sheeraz Khan6Zeeshan Khatri7Center of Excellence in Nanotechnology and Materials, Mehran University of Engineering and Technology, Jamshoro 76062, PakistanCenter of Excellence in Nanotechnology and Materials, Mehran University of Engineering and Technology, Jamshoro 76062, PakistanDepartment of Prosthodontics, College of Dentistry, King Khalid University, Abha 61421, Saudi ArabiaDepartment of Water Sanitation and Health Sciences, US-Pakistan Center for Advanced Studies in Water (USPCAS-W), Mehran University of Engineering and Technology, Jamshoro 76060, PakistanCenter of Excellence in Nanotechnology and Materials, Mehran University of Engineering and Technology, Jamshoro 76062, PakistanNano Fusion Technology Research Lab, Division of Frontier Fibers, Institute for Fiber Engineering (IFES), Interdisciplinary Cluster of Cutting-Edge Research (ICCER), Shishu University, Tokida 3-15-1, Ueda 386-8567, JapanCenter of Excellence in Nanotechnology and Materials, Mehran University of Engineering and Technology, Jamshoro 76062, PakistanCenter of Excellence in Nanotechnology and Materials, Mehran University of Engineering and Technology, Jamshoro 76062, PakistanNanotechnology provides solutions by combining the fields of textiles and medicine to prevent infectious microbial spread. Our study aimed to evaluate the antimicrobial activity of nanofiber sheets incorporated with a well-known antibiotic, ceftriaxone. It is a third-generation antibiotic that belongs to the cephalosporin group. Different percentages (0, 5%, 10%, 15%, and 20%; based on polymer wt%) of ceftriaxone were incorporated with a polymer such as polyvinyl alcohol (PVA) via electrospinning to fabricate nanofiber sheets. The Kirby-Bauer method was used to evaluate the antimicrobial susceptibility of the nanofiber sheets using <i>Escherichia coli</i> (<i>E. coli</i>) and <i>Staphylococcus aureus</i> (<i>S. aureus</i>). For the characterization of the nanofiber sheets incorporated with the drug, several techniques were used, such as Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and scanning electron microscopy (SEM). Our results showed that the nanofiber sheets containing ceftriaxone had potential inhibitory activity against <i>E. coli</i> and <i>S. aureus</i> as they had inhibition zones of approximately 20–25 mm on Mueller-Hinton-agar-containing plates. In conclusion, our nanofiber sheets fabricated with ceftriaxone have potential inhibitory effects against bacteria and can be used as a dressing to treat wounds in hospitals and for other biomedical applications.https://www.mdpi.com/2079-6382/11/3/352antibioticsceftriaxonenanofibers<i>E. coli</i><i>S. aureus</i> |
| spellingShingle | Youdhestar Faraz Khan Mahar Gotam Das Ayesha Tajammul Farooq Ahmed Muzamil Khatri Sheeraz Khan Zeeshan Khatri Fabrication of Ceftriaxone-Loaded Cellulose Acetate and Polyvinyl Alcohol Nanofibers and Their Antibacterial Evaluation Antibiotics antibiotics ceftriaxone nanofibers <i>E. coli</i> <i>S. aureus</i> |
| title | Fabrication of Ceftriaxone-Loaded Cellulose Acetate and Polyvinyl Alcohol Nanofibers and Their Antibacterial Evaluation |
| title_full | Fabrication of Ceftriaxone-Loaded Cellulose Acetate and Polyvinyl Alcohol Nanofibers and Their Antibacterial Evaluation |
| title_fullStr | Fabrication of Ceftriaxone-Loaded Cellulose Acetate and Polyvinyl Alcohol Nanofibers and Their Antibacterial Evaluation |
| title_full_unstemmed | Fabrication of Ceftriaxone-Loaded Cellulose Acetate and Polyvinyl Alcohol Nanofibers and Their Antibacterial Evaluation |
| title_short | Fabrication of Ceftriaxone-Loaded Cellulose Acetate and Polyvinyl Alcohol Nanofibers and Their Antibacterial Evaluation |
| title_sort | fabrication of ceftriaxone loaded cellulose acetate and polyvinyl alcohol nanofibers and their antibacterial evaluation |
| topic | antibiotics ceftriaxone nanofibers <i>E. coli</i> <i>S. aureus</i> |
| url | https://www.mdpi.com/2079-6382/11/3/352 |
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