Curcumin against Prostate Cancer: Current Evidence
Cancer is a condition characterized by remarkably enhanced rates of cell proliferation paired with evasion of cell death. These deregulated cellular processes take place following genetic mutations leading to the activation of oncogenes, the loss of tumor suppressor genes, and the disruption of key...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/10/11/1536 |
| _version_ | 1797548241502339072 |
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| author | Deborah Termini Danja J. Den Hartogh Alina Jaglanian Evangelia Tsiani |
| author_facet | Deborah Termini Danja J. Den Hartogh Alina Jaglanian Evangelia Tsiani |
| author_sort | Deborah Termini |
| collection | DOAJ |
| description | Cancer is a condition characterized by remarkably enhanced rates of cell proliferation paired with evasion of cell death. These deregulated cellular processes take place following genetic mutations leading to the activation of oncogenes, the loss of tumor suppressor genes, and the disruption of key signaling pathways that control and promote homeostasis. Plant extracts and plant-derived compounds have historically been utilized as medicinal remedies in different cultures due to their anti-inflammatory, antioxidant, and antimicrobial properties. Many chemotherapeutic agents used in the treatment of cancer are derived from plants, and the scientific interest in discovering plant-derived chemicals with anticancer potential continues today. Curcumin, a turmeric-derived polyphenol, has been reported to possess antiproliferative and proapoptotic properties. In the present review, we summarize all the in vitro and in vivo studies examining the effects of curcumin in prostate cancer. |
| first_indexed | 2024-03-10T14:56:32Z |
| format | Article |
| id | doaj.art-097b34ae465345c68e9f11b4a68fff72 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T14:56:32Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-097b34ae465345c68e9f11b4a68fff722023-11-20T20:29:23ZengMDPI AGBiomolecules2218-273X2020-11-011011153610.3390/biom10111536Curcumin against Prostate Cancer: Current EvidenceDeborah Termini0Danja J. Den Hartogh1Alina Jaglanian2Evangelia Tsiani3Department of Health Sciences, Brock University, St. Catharines, ON L2S 3A1, CanadaDepartment of Health Sciences, Brock University, St. Catharines, ON L2S 3A1, CanadaDepartment of Health Sciences, Brock University, St. Catharines, ON L2S 3A1, CanadaDepartment of Health Sciences, Brock University, St. Catharines, ON L2S 3A1, CanadaCancer is a condition characterized by remarkably enhanced rates of cell proliferation paired with evasion of cell death. These deregulated cellular processes take place following genetic mutations leading to the activation of oncogenes, the loss of tumor suppressor genes, and the disruption of key signaling pathways that control and promote homeostasis. Plant extracts and plant-derived compounds have historically been utilized as medicinal remedies in different cultures due to their anti-inflammatory, antioxidant, and antimicrobial properties. Many chemotherapeutic agents used in the treatment of cancer are derived from plants, and the scientific interest in discovering plant-derived chemicals with anticancer potential continues today. Curcumin, a turmeric-derived polyphenol, has been reported to possess antiproliferative and proapoptotic properties. In the present review, we summarize all the in vitro and in vivo studies examining the effects of curcumin in prostate cancer.https://www.mdpi.com/2218-273X/10/11/1536prostate cancerproliferationapoptosissurvivalandrogen-sensitiveandrogen-insensitive |
| spellingShingle | Deborah Termini Danja J. Den Hartogh Alina Jaglanian Evangelia Tsiani Curcumin against Prostate Cancer: Current Evidence Biomolecules prostate cancer proliferation apoptosis survival androgen-sensitive androgen-insensitive |
| title | Curcumin against Prostate Cancer: Current Evidence |
| title_full | Curcumin against Prostate Cancer: Current Evidence |
| title_fullStr | Curcumin against Prostate Cancer: Current Evidence |
| title_full_unstemmed | Curcumin against Prostate Cancer: Current Evidence |
| title_short | Curcumin against Prostate Cancer: Current Evidence |
| title_sort | curcumin against prostate cancer current evidence |
| topic | prostate cancer proliferation apoptosis survival androgen-sensitive androgen-insensitive |
| url | https://www.mdpi.com/2218-273X/10/11/1536 |
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