Administration of the GLP-1 receptor agonist exenatide in rats improves functional recovery after spinal cord injury by reducing endoplasmic reticulum stress

Administration of the GLP-1 receptor agonist exenatide in rats improves functional recovery after spinal cord injury by reducing endoplasmic reticulum stress

After spinal cord injury (SCI), endoplasmic reticulum (ER) stress has been reported to be an integral part of the secondary injury process that causes apoptosis of glial cells, leading to remyelination failure. This report focuses on exenatide, a glucagon-like peptide-1 (GLP-1) receptor agonist wide...

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Bibliographic Details
Main Authors: Satoshi Nomura, Hiroyuki Katoh, Sho Yanagisawa, Toshihiro Noguchi, Keiko Okada, Masahiko Watanabe
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:IBRO Neuroscience Reports
Subjects:
Spinal cord injury
Endoplasmic reticulum stress
Glucagon-like peptide-1 (GLP-1)
Glucose-regulated protein78 (GRP78)
C/EBP homologous transcription factor protein (CHOP)
Online Access:http://www.sciencedirect.com/science/article/pii/S2667242123022601

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