Diagnostic Value of the Neutrophil-to-Lymphocyte Ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) in Various Respiratory Diseases: A Retrospective Analysis
The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte (PLR) ratio are two extensively used inflammatory markers that have been proved very useful in evaluating inflammation in several diseases. The present article aimed to investigate if they have any value in distinguishing among vari...
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| Format: | Article |
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MDPI AG
2021-12-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/1/81 |
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| author | Milena-Adina Man Lavinia Davidescu Nicoleta-Stefania Motoc Ruxandra-Mioara Rajnoveanu Cosmina-Ioana Bondor Carmen-Monica Pop Claudia Toma |
| author_facet | Milena-Adina Man Lavinia Davidescu Nicoleta-Stefania Motoc Ruxandra-Mioara Rajnoveanu Cosmina-Ioana Bondor Carmen-Monica Pop Claudia Toma |
| author_sort | Milena-Adina Man |
| collection | DOAJ |
| description | The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte (PLR) ratio are two extensively used inflammatory markers that have been proved very useful in evaluating inflammation in several diseases. The present article aimed to investigate if they have any value in distinguishing among various respiratory disorders. One hundred and forty-five patients with coronavirus disease 2019 (COVID-19), 219 patients with different chronic respiratory diseases (interstitial lung disease, obstructive sleep apnea(OSA)-chronic obstructive pulmonary disease (COPD) overlap syndrome, bronchiectasis) and 161 healthy individuals as a control group were included in the study. While neither NLR nor PLR had any power in differentiating between various diseases, PLR was found to be significant but poor as a diagnostic test when the control group was compared with the OSA-COPD group. NLR was found to be significant but poor as a diagnostic test when we compared the control group with all three groups (separately): the OSA-COPD group; interstitial lung disease group, and bronchiectasis group. NLR and PLR had poor power to discriminate between various respiratory diseases and cannot be used in making the differential diagnosis. |
| first_indexed | 2024-03-10T01:39:03Z |
| format | Article |
| id | doaj.art-097ce4395ec24559a18b3a12524aa52e |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T01:39:03Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-097ce4395ec24559a18b3a12524aa52e2023-11-23T13:27:54ZengMDPI AGDiagnostics2075-44182021-12-011218110.3390/diagnostics12010081Diagnostic Value of the Neutrophil-to-Lymphocyte Ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) in Various Respiratory Diseases: A Retrospective AnalysisMilena-Adina Man0Lavinia Davidescu1Nicoleta-Stefania Motoc2Ruxandra-Mioara Rajnoveanu3Cosmina-Ioana Bondor4Carmen-Monica Pop5Claudia Toma6Department of Medical Sciences, Pulmonology, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400000 Cluj Napoca, RomaniaFaculty of Medicine and Pharmacy, University of Oradea, 410087 Oradea, RomaniaDepartment of Medical Sciences, Pulmonology, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400000 Cluj Napoca, RomaniaDepartment of Medical Sciences, Pulmonology, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400000 Cluj Napoca, RomaniaDepartment of Medical Biostatistics, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400000 Cluj Napoca, RomaniaDepartment of Medical Sciences, Pulmonology, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400000 Cluj Napoca, RomaniaFaculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, RomaniaThe neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte (PLR) ratio are two extensively used inflammatory markers that have been proved very useful in evaluating inflammation in several diseases. The present article aimed to investigate if they have any value in distinguishing among various respiratory disorders. One hundred and forty-five patients with coronavirus disease 2019 (COVID-19), 219 patients with different chronic respiratory diseases (interstitial lung disease, obstructive sleep apnea(OSA)-chronic obstructive pulmonary disease (COPD) overlap syndrome, bronchiectasis) and 161 healthy individuals as a control group were included in the study. While neither NLR nor PLR had any power in differentiating between various diseases, PLR was found to be significant but poor as a diagnostic test when the control group was compared with the OSA-COPD group. NLR was found to be significant but poor as a diagnostic test when we compared the control group with all three groups (separately): the OSA-COPD group; interstitial lung disease group, and bronchiectasis group. NLR and PLR had poor power to discriminate between various respiratory diseases and cannot be used in making the differential diagnosis.https://www.mdpi.com/2075-4418/12/1/81respiratory diseasesinflammatory markersneutrophil-to-lymphocyte ratio (NLR)platelet-to-lymphocyte (PLR) |
| spellingShingle | Milena-Adina Man Lavinia Davidescu Nicoleta-Stefania Motoc Ruxandra-Mioara Rajnoveanu Cosmina-Ioana Bondor Carmen-Monica Pop Claudia Toma Diagnostic Value of the Neutrophil-to-Lymphocyte Ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) in Various Respiratory Diseases: A Retrospective Analysis Diagnostics respiratory diseases inflammatory markers neutrophil-to-lymphocyte ratio (NLR) platelet-to-lymphocyte (PLR) |
| title | Diagnostic Value of the Neutrophil-to-Lymphocyte Ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) in Various Respiratory Diseases: A Retrospective Analysis |
| title_full | Diagnostic Value of the Neutrophil-to-Lymphocyte Ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) in Various Respiratory Diseases: A Retrospective Analysis |
| title_fullStr | Diagnostic Value of the Neutrophil-to-Lymphocyte Ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) in Various Respiratory Diseases: A Retrospective Analysis |
| title_full_unstemmed | Diagnostic Value of the Neutrophil-to-Lymphocyte Ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) in Various Respiratory Diseases: A Retrospective Analysis |
| title_short | Diagnostic Value of the Neutrophil-to-Lymphocyte Ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) in Various Respiratory Diseases: A Retrospective Analysis |
| title_sort | diagnostic value of the neutrophil to lymphocyte ratio nlr and platelet to lymphocyte ratio plr in various respiratory diseases a retrospective analysis |
| topic | respiratory diseases inflammatory markers neutrophil-to-lymphocyte ratio (NLR) platelet-to-lymphocyte (PLR) |
| url | https://www.mdpi.com/2075-4418/12/1/81 |
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