Comparative Genomics Reveals a Single Nucleotide Deletion in pksP That Results in White-Spore Phenotype in Natural Variants of Aspergillus fumigatus

Comparative Genomics Reveals a Single Nucleotide Deletion in pksP That Results in White-Spore Phenotype in Natural Variants of Aspergillus fumigatus

Aspergillus fumigatus is a potentially deadly opportunistic human pathogen. A. fumigatus has evolved a variety of mechanisms to evade detection by the immune system. For example, the conidium surface is covered in a layer of 1,8-dihydroxynaphthalene (DHN) melanin which masks the antigen macrophages...

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Bibliographic Details
Main Authors: John G. Gibbons, Paolo D’Avino, Shu Zhao, Grace W. Cox, David C. Rinker, Jarrod R. Fortwendel, Jean-Paul Latge
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Fungal Biology
Subjects:
Aspergillus
albinism
genomics
pksP gene
1,8-Dihydroxynaphthalene (DHN) melanin
Online Access:https://www.frontiersin.org/articles/10.3389/ffunb.2022.897954/full

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