Effects of sarcopenia and sarcopenic obesity on joint pain and degenerative osteoarthritis in postmenopausal women
Abstract This study aimed to identify the prevalence of sarcopenia, obesity, and sarcopenic obesity and examine their association with radiographic knee osteoarthritis (OA) and knee pain in Korean postmenopausal women. This cross-sectional study utilized the data from Korean National Health and Nutr...
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| Format: | Article |
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Nature Portfolio
2022-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-17451-1 |
| _version_ | 1818084269117931520 |
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| author | Hye In Kim So Hyun Ahn Yup Kim Ji Eun Lee Euna Choi Seok Kyo Seo |
| author_facet | Hye In Kim So Hyun Ahn Yup Kim Ji Eun Lee Euna Choi Seok Kyo Seo |
| author_sort | Hye In Kim |
| collection | DOAJ |
| description | Abstract This study aimed to identify the prevalence of sarcopenia, obesity, and sarcopenic obesity and examine their association with radiographic knee osteoarthritis (OA) and knee pain in Korean postmenopausal women. This cross-sectional study utilized the data from Korean National Health and Nutrition Examination Surveys 2009–2011. The participants were categorized into 4 groups based on body composition: either sarcopenic (appendicular skeletal muscle < 23%) or not, either obese (body mass index ≥ 25.0 kg/m2) or not. The prevalence of radiographic knee OA and knee pain was calculated. The effect of hormone replacement therapy (HRT) was also evaluated. The prevalence of radiographic knee OA, knee pain, and both were all highest in the sarcopenic obese group and lowest in the control group (61.49% vs. 41.54%, 39.11% vs. 27.55%, 32.04% vs. 17.82%, all p < 0.001). Without sarcopenia, obese women showed significantly higher ratio of radiographic knee OA only (57.64% vs. 41.54%, p < 0.001). With sarcopenia, the coexistence of obesity presented higher ratio of radiographic knee OA, knee pain, and both compared to sarcopenia without obesity (61.49% vs. 41.82%, 39.11% vs. 27.61%, 32.04% vs. 17.60%, all p < 0.001). The use of HRT for more than 1 year was not associated with radiographic knee OA, knee pain, or both (p = 0.147, 0.689 and 0.649, respectively). Obesity with sarcopenia had greater effect on knee OA compared to obesity without sarcopenia. Moreover, HRT use for more than 1 year was not associated with the prevalence of knee OA. Therefore, more efforts should focus on reducing body fat and increasing muscle in postmenopausal women with knee OA. |
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| format | Article |
| id | doaj.art-0980ce8c2da74c5eaf205554b799f42c |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-10T19:51:12Z |
| publishDate | 2022-08-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj.art-0980ce8c2da74c5eaf205554b799f42c2022-12-22T01:35:45ZengNature PortfolioScientific Reports2045-23222022-08-011211810.1038/s41598-022-17451-1Effects of sarcopenia and sarcopenic obesity on joint pain and degenerative osteoarthritis in postmenopausal womenHye In Kim0So Hyun Ahn1Yup Kim2Ji Eun Lee3Euna Choi4Seok Kyo Seo5Department of Obstetrics and Gynecology, Severance Hospital, Yonsei University College of MedicineDepartment of Obstetrics and Gynecology, Severance Hospital, Yonsei University College of MedicineDepartment of Obstetrics and Gynecology, Severance Hospital, Yonsei University College of MedicineDepartment of Obstetrics and Gynecology, Severance Hospital, Yonsei University College of MedicineDepartment of Obstetrics and Gynecology, Severance Hospital, Yonsei University College of MedicineDepartment of Obstetrics and Gynecology, Severance Hospital, Yonsei University College of MedicineAbstract This study aimed to identify the prevalence of sarcopenia, obesity, and sarcopenic obesity and examine their association with radiographic knee osteoarthritis (OA) and knee pain in Korean postmenopausal women. This cross-sectional study utilized the data from Korean National Health and Nutrition Examination Surveys 2009–2011. The participants were categorized into 4 groups based on body composition: either sarcopenic (appendicular skeletal muscle < 23%) or not, either obese (body mass index ≥ 25.0 kg/m2) or not. The prevalence of radiographic knee OA and knee pain was calculated. The effect of hormone replacement therapy (HRT) was also evaluated. The prevalence of radiographic knee OA, knee pain, and both were all highest in the sarcopenic obese group and lowest in the control group (61.49% vs. 41.54%, 39.11% vs. 27.55%, 32.04% vs. 17.82%, all p < 0.001). Without sarcopenia, obese women showed significantly higher ratio of radiographic knee OA only (57.64% vs. 41.54%, p < 0.001). With sarcopenia, the coexistence of obesity presented higher ratio of radiographic knee OA, knee pain, and both compared to sarcopenia without obesity (61.49% vs. 41.82%, 39.11% vs. 27.61%, 32.04% vs. 17.60%, all p < 0.001). The use of HRT for more than 1 year was not associated with radiographic knee OA, knee pain, or both (p = 0.147, 0.689 and 0.649, respectively). Obesity with sarcopenia had greater effect on knee OA compared to obesity without sarcopenia. Moreover, HRT use for more than 1 year was not associated with the prevalence of knee OA. Therefore, more efforts should focus on reducing body fat and increasing muscle in postmenopausal women with knee OA.https://doi.org/10.1038/s41598-022-17451-1 |
| spellingShingle | Hye In Kim So Hyun Ahn Yup Kim Ji Eun Lee Euna Choi Seok Kyo Seo Effects of sarcopenia and sarcopenic obesity on joint pain and degenerative osteoarthritis in postmenopausal women Scientific Reports |
| title | Effects of sarcopenia and sarcopenic obesity on joint pain and degenerative osteoarthritis in postmenopausal women |
| title_full | Effects of sarcopenia and sarcopenic obesity on joint pain and degenerative osteoarthritis in postmenopausal women |
| title_fullStr | Effects of sarcopenia and sarcopenic obesity on joint pain and degenerative osteoarthritis in postmenopausal women |
| title_full_unstemmed | Effects of sarcopenia and sarcopenic obesity on joint pain and degenerative osteoarthritis in postmenopausal women |
| title_short | Effects of sarcopenia and sarcopenic obesity on joint pain and degenerative osteoarthritis in postmenopausal women |
| title_sort | effects of sarcopenia and sarcopenic obesity on joint pain and degenerative osteoarthritis in postmenopausal women |
| url | https://doi.org/10.1038/s41598-022-17451-1 |
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