Targeting Endocytosis and Cell Communications in the Tumor Immune Microenvironment
Abstract The existence of multiple endocytic pathways is well known, and their exact biological effects in tumors have been intensively investigated. Endocytosis can affect the connection between tumor cells and determine the fate of tumor cells. Many relationships between endocytosis and tumor cell...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-10-01
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| Series: | Cell Communication and Signaling |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12964-022-00968-3 |
| _version_ | 1828096165762039808 |
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| author | Bo Wu Qian Wang Xiang Shi Meixi Jiang |
| author_facet | Bo Wu Qian Wang Xiang Shi Meixi Jiang |
| author_sort | Bo Wu |
| collection | DOAJ |
| description | Abstract The existence of multiple endocytic pathways is well known, and their exact biological effects in tumors have been intensively investigated. Endocytosis can affect the connection between tumor cells and determine the fate of tumor cells. Many relationships between endocytosis and tumor cells have been elucidated, but the mechanism of endocytosis between different types of cells in tumors needs to be explored in greater depth. Endocytic receptors sense the environment and are induced by specific ligands to trigger communication between tumor and immune cells. Crosstalk in the tumor microenvironment can occur through direct contact between cell adhesion molecules or indirectly through exosomes. So a better understanding of the endocytic pathways that control cell adhesion molecules and function is expected to lead to new candidates for cancer treatment. In additional, tumor-derived exosomes may changes immune cell function, which may be a key role for tumors to evade immune detection and response. The overall understanding of exosomes through endocytosis is also expected to bring new candidates for therapeutic regulation of tumor immune microenvironment. In this case, endocytic pathways coordinate cell adhesion molecules and exosomes and can be used as targets in the tumor immune microenvironment for cancer treatment. Video Abstract |
| first_indexed | 2024-04-11T07:26:03Z |
| format | Article |
| id | doaj.art-09815e4da85842bdafa01285d6145cf2 |
| institution | Directory Open Access Journal |
| issn | 1478-811X |
| language | English |
| last_indexed | 2024-04-11T07:26:03Z |
| publishDate | 2022-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj.art-09815e4da85842bdafa01285d6145cf22022-12-22T04:37:04ZengBMCCell Communication and Signaling1478-811X2022-10-0120111010.1186/s12964-022-00968-3Targeting Endocytosis and Cell Communications in the Tumor Immune MicroenvironmentBo Wu0Qian Wang1Xiang Shi2Meixi Jiang3Department of General Surgery, The Fourth Affiliated Hospital, China Medical UniversityDepartment of Radiology, The Fifth Hospital of XiamenDepartment of Thoracic Surgery, Cancer Hospital of Liaoning Province, China Medical UniversityDepartment of Neurology, The Fourth Affiliated Hospital, China Medical UniversityAbstract The existence of multiple endocytic pathways is well known, and their exact biological effects in tumors have been intensively investigated. Endocytosis can affect the connection between tumor cells and determine the fate of tumor cells. Many relationships between endocytosis and tumor cells have been elucidated, but the mechanism of endocytosis between different types of cells in tumors needs to be explored in greater depth. Endocytic receptors sense the environment and are induced by specific ligands to trigger communication between tumor and immune cells. Crosstalk in the tumor microenvironment can occur through direct contact between cell adhesion molecules or indirectly through exosomes. So a better understanding of the endocytic pathways that control cell adhesion molecules and function is expected to lead to new candidates for cancer treatment. In additional, tumor-derived exosomes may changes immune cell function, which may be a key role for tumors to evade immune detection and response. The overall understanding of exosomes through endocytosis is also expected to bring new candidates for therapeutic regulation of tumor immune microenvironment. In this case, endocytic pathways coordinate cell adhesion molecules and exosomes and can be used as targets in the tumor immune microenvironment for cancer treatment. Video Abstracthttps://doi.org/10.1186/s12964-022-00968-3EndocytosisTumor immune microenvironmentAdhesion moleculesExosome |
| spellingShingle | Bo Wu Qian Wang Xiang Shi Meixi Jiang Targeting Endocytosis and Cell Communications in the Tumor Immune Microenvironment Cell Communication and Signaling Endocytosis Tumor immune microenvironment Adhesion molecules Exosome |
| title | Targeting Endocytosis and Cell Communications in the Tumor Immune Microenvironment |
| title_full | Targeting Endocytosis and Cell Communications in the Tumor Immune Microenvironment |
| title_fullStr | Targeting Endocytosis and Cell Communications in the Tumor Immune Microenvironment |
| title_full_unstemmed | Targeting Endocytosis and Cell Communications in the Tumor Immune Microenvironment |
| title_short | Targeting Endocytosis and Cell Communications in the Tumor Immune Microenvironment |
| title_sort | targeting endocytosis and cell communications in the tumor immune microenvironment |
| topic | Endocytosis Tumor immune microenvironment Adhesion molecules Exosome |
| url | https://doi.org/10.1186/s12964-022-00968-3 |
| work_keys_str_mv | AT bowu targetingendocytosisandcellcommunicationsinthetumorimmunemicroenvironment AT qianwang targetingendocytosisandcellcommunicationsinthetumorimmunemicroenvironment AT xiangshi targetingendocytosisandcellcommunicationsinthetumorimmunemicroenvironment AT meixijiang targetingendocytosisandcellcommunicationsinthetumorimmunemicroenvironment |