Polyphyllin II Induces Protective Autophagy and Apoptosis via Inhibiting PI3K/AKT/mTOR and STAT3 Signaling in Colorectal Cancer Cells

Polyphyllin II Induces Protective Autophagy and Apoptosis via Inhibiting PI3K/AKT/mTOR and STAT3 Signaling in Colorectal Cancer Cells

Polyphyllin II (PPII) is a natural steroidal saponin occurring in <i>Rhizoma Paridis</i>. It has been demonstrated to exhibit anti-cancer activity against a variety of cancer cells. However, the anti-colorectal cancer (CRC) effects and mechanism of action of PPII are rarely reported. In...

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Bibliographic Details
Main Authors: Jun-Kui Li, Hai-Tao Sun, Xiao-Li Jiang, Yi-Fei Chen, Zhu Zhang, Ying Wang, Wen-Qing Chen, Zhang Zhang, Stephen Cho Wing Sze, Pei-Li Zhu, Ken Kin Lam Yung
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
polyphyllin II
colorectal cancer
cell cycle arrest
apoptosis
autophagy
PI3K/AKT/mTOR
Online Access:https://www.mdpi.com/1422-0067/23/19/11890

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