Association between Individual Norepinephrine Transporter (NET) Availability and Response to Pharmacological Therapy in Adults with Attention-Deficit/Hyperactivity Disorder (ADHD)
Background: The role of the norepinephrine transporter (NET) has received increased focus in recent studies on the pathogenesis of attention-deficit/hyperactivity disorder (ADHD). The predictive value for pharmacological treatment and its link to other health or social limitations has been little-st...
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MDPI AG
2022-07-01
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| Online Access: | https://www.mdpi.com/2076-3425/12/8/965 |
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| author | Jue Huang Nicole Mauche Michael Rullmann Christine Ulke Georg-Alexander Becker Marianne Patt Franziska Zientek Swen Hesse Osama Sabri Maria Strauß |
| author_facet | Jue Huang Nicole Mauche Michael Rullmann Christine Ulke Georg-Alexander Becker Marianne Patt Franziska Zientek Swen Hesse Osama Sabri Maria Strauß |
| author_sort | Jue Huang |
| collection | DOAJ |
| description | Background: The role of the norepinephrine transporter (NET) has received increased focus in recent studies on the pathogenesis of attention-deficit/hyperactivity disorder (ADHD). The predictive value for pharmacological treatment and its link to other health or social limitations has been little-studied. This follow-up research on adult patients with ADHD aimed to explore whether the therapy response and health and social impairments depend on baseline individual NET availability. Methods: Data were collected from 10 patients on personal, family and professional situations, mental and physical health and treatments received after baseline via online and telephone surveys and were compared to baseline data to evaluate treatment-related changes. Results: The majority of our ADHD patients did not show therapy responses but showed improvements due to pharmacological treatment. There was no evidence of relationships between pre-treatment NET availability and therapy response or health/social limitations. Conclusions: Pharmacological monotherapy was insufficient to promote symptom remission, especially for participants with extreme insufficiency in NET availability, but improved outcomes in academic and social functioning. Psychotherapy should be considered as an add-on to the standard treatment approach due to its positive outcome in reducing social limitations. The prognostic value of individual NET availability in predicting the response to therapy needs further studies with large sample sizes. |
| first_indexed | 2024-03-09T09:58:58Z |
| format | Article |
| id | doaj.art-0981fee64f8441b7a1ce9b85a9bc1f84 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-09T09:58:58Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-0981fee64f8441b7a1ce9b85a9bc1f842023-12-01T23:30:38ZengMDPI AGBrain Sciences2076-34252022-07-0112896510.3390/brainsci12080965Association between Individual Norepinephrine Transporter (NET) Availability and Response to Pharmacological Therapy in Adults with Attention-Deficit/Hyperactivity Disorder (ADHD)Jue Huang0Nicole Mauche1Michael Rullmann2Christine Ulke3Georg-Alexander Becker4Marianne Patt5Franziska Zientek6Swen Hesse7Osama Sabri8Maria Strauß9Department of Psychiatry and Psychotherapy, University of Leipzig Medical Center, 04103 Leipzig, GermanyDepartment of Psychiatry and Psychotherapy, University of Leipzig Medical Center, 04103 Leipzig, GermanyDepartment of Nuclear Medicine, University of Leipzig Medical Center, 04103 Leipzig, GermanyDepartment of Psychiatry and Psychotherapy, University of Leipzig Medical Center, 04103 Leipzig, GermanyDepartment of Nuclear Medicine, University of Leipzig Medical Center, 04103 Leipzig, GermanyDepartment of Nuclear Medicine, University of Leipzig Medical Center, 04103 Leipzig, GermanyDepartment of Nuclear Medicine, University of Leipzig Medical Center, 04103 Leipzig, GermanyDepartment of Nuclear Medicine, University of Leipzig Medical Center, 04103 Leipzig, GermanyDepartment of Nuclear Medicine, University of Leipzig Medical Center, 04103 Leipzig, GermanyDepartment of Psychiatry and Psychotherapy, University of Leipzig Medical Center, 04103 Leipzig, GermanyBackground: The role of the norepinephrine transporter (NET) has received increased focus in recent studies on the pathogenesis of attention-deficit/hyperactivity disorder (ADHD). The predictive value for pharmacological treatment and its link to other health or social limitations has been little-studied. This follow-up research on adult patients with ADHD aimed to explore whether the therapy response and health and social impairments depend on baseline individual NET availability. Methods: Data were collected from 10 patients on personal, family and professional situations, mental and physical health and treatments received after baseline via online and telephone surveys and were compared to baseline data to evaluate treatment-related changes. Results: The majority of our ADHD patients did not show therapy responses but showed improvements due to pharmacological treatment. There was no evidence of relationships between pre-treatment NET availability and therapy response or health/social limitations. Conclusions: Pharmacological monotherapy was insufficient to promote symptom remission, especially for participants with extreme insufficiency in NET availability, but improved outcomes in academic and social functioning. Psychotherapy should be considered as an add-on to the standard treatment approach due to its positive outcome in reducing social limitations. The prognostic value of individual NET availability in predicting the response to therapy needs further studies with large sample sizes.https://www.mdpi.com/2076-3425/12/8/965ADHDpsychostimulantnon-stimulantcomorbiditydepressionanxiety |
| spellingShingle | Jue Huang Nicole Mauche Michael Rullmann Christine Ulke Georg-Alexander Becker Marianne Patt Franziska Zientek Swen Hesse Osama Sabri Maria Strauß Association between Individual Norepinephrine Transporter (NET) Availability and Response to Pharmacological Therapy in Adults with Attention-Deficit/Hyperactivity Disorder (ADHD) Brain Sciences ADHD psychostimulant non-stimulant comorbidity depression anxiety |
| title | Association between Individual Norepinephrine Transporter (NET) Availability and Response to Pharmacological Therapy in Adults with Attention-Deficit/Hyperactivity Disorder (ADHD) |
| title_full | Association between Individual Norepinephrine Transporter (NET) Availability and Response to Pharmacological Therapy in Adults with Attention-Deficit/Hyperactivity Disorder (ADHD) |
| title_fullStr | Association between Individual Norepinephrine Transporter (NET) Availability and Response to Pharmacological Therapy in Adults with Attention-Deficit/Hyperactivity Disorder (ADHD) |
| title_full_unstemmed | Association between Individual Norepinephrine Transporter (NET) Availability and Response to Pharmacological Therapy in Adults with Attention-Deficit/Hyperactivity Disorder (ADHD) |
| title_short | Association between Individual Norepinephrine Transporter (NET) Availability and Response to Pharmacological Therapy in Adults with Attention-Deficit/Hyperactivity Disorder (ADHD) |
| title_sort | association between individual norepinephrine transporter net availability and response to pharmacological therapy in adults with attention deficit hyperactivity disorder adhd |
| topic | ADHD psychostimulant non-stimulant comorbidity depression anxiety |
| url | https://www.mdpi.com/2076-3425/12/8/965 |
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