Review on Efficacy and Safety of Newer Oral Anticoagulants for Deep Vein Thrombosis Patient
Background. Warfarin is a standard medication for deep vein thrombosis (DVT). However, there are some limitations of its use due to the need of regular monitoring and problems of drug to drug and drug to food interactions. Newer oral anticoagulants (NOAC) is being considered as substitution to warfa...
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| Format: | Article |
| Language: | English |
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Indonesian Heart Association
2013-06-01
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| Series: | Majalah Kardiologi Indonesia |
| Subjects: | |
| Online Access: | http://ijconline.id/index.php/ijc/article/view/31 |
| _version_ | 1819027683312402432 |
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| author | Ridwan Rasyid Pringgodigdo Nugroho Yoga Yuniadi |
| author_facet | Ridwan Rasyid Pringgodigdo Nugroho Yoga Yuniadi |
| author_sort | Ridwan Rasyid |
| collection | DOAJ |
| description | Background. Warfarin is a standard medication for deep vein thrombosis (DVT). However, there are some limitations of its use due to the need of regular monitoring and problems of drug to drug and drug to food interactions. Newer oral anticoagulants (NOAC) is being considered as substitution to warfarin, yet they need some evidences on its safety and efficacy. This evidence case report is aimed to elaborate safety and efficacy of NOAC (dabigatran and rivaroxaban) in the setting of DVT.
Methods and Results. Relevant articles are searched in Pubmed and Proquest database. Only recent article which less than 5 year publication included in this study. RE-COVER study showed non-inferiority of dabigatran as compare to warfarin in treating DVT patients. Mortality rate and recurrent rate of DVT were 2.4% vs. 2.1% in dabigatran and warfarin respectively (HR=1,10 CI 95% = 0,65-1,84). Dabigatran showed less bleeding rate compare to warfarin, 5.6% vs. 8.8% respectively (HR = 0,63
CI95% = 0,47 - 0,84; RRR =29%, p = 0,0002). Similar results is shown in EINSTEIN study that compares rivaroxaban with warfarin. Mortality rate and recurrent rate of DVT were 2.1% vs. 3% in rivaroxaban and warfarin respectively (HR=0,68 CI 95% = 0,44-1,04). Total bleeding rate were
7.3% vs. 7% and major bleeding were 0.8% vs. 1.2% in rivaroxaban and warfarin respectively.
Conclusion. Both dabigatran and rivaroxaban showed non inferior efficacy as compare to warfarin in the treatment of DVT, and slightly better bleeding rate. |
| first_indexed | 2024-12-21T05:46:22Z |
| format | Article |
| id | doaj.art-09821a7eb1394a929b6d4ea1d51ace1e |
| institution | Directory Open Access Journal |
| issn | 0126-3773 2620-4762 |
| language | English |
| last_indexed | 2024-12-21T05:46:22Z |
| publishDate | 2013-06-01 |
| publisher | Indonesian Heart Association |
| record_format | Article |
| series | Majalah Kardiologi Indonesia |
| spelling | doaj.art-09821a7eb1394a929b6d4ea1d51ace1e2022-12-21T19:14:07ZengIndonesian Heart AssociationMajalah Kardiologi Indonesia0126-37732620-47622013-06-0133410.30701/ijc.v33i4.31Review on Efficacy and Safety of Newer Oral Anticoagulants for Deep Vein Thrombosis PatientRidwan Rasyid0Pringgodigdo Nugroho1Yoga Yuniadi2Departement of Cardiology and Vascular Medicine, Faculty of Medi-cine University of Indonesia, and National Cardiovascular Center Harapan Kita, JakartaDepartement of Cardiology and Vascular Medicine, Faculty of Medi-cine University of Indonesia, and National Cardiovascular Center Harapan Kita, JakartaDepartement of Cardiology and Vascular Medicine, Faculty of Medi-cine University of Indonesia, and National Cardiovascular Center Harapan Kita, JakartaBackground. Warfarin is a standard medication for deep vein thrombosis (DVT). However, there are some limitations of its use due to the need of regular monitoring and problems of drug to drug and drug to food interactions. Newer oral anticoagulants (NOAC) is being considered as substitution to warfarin, yet they need some evidences on its safety and efficacy. This evidence case report is aimed to elaborate safety and efficacy of NOAC (dabigatran and rivaroxaban) in the setting of DVT. Methods and Results. Relevant articles are searched in Pubmed and Proquest database. Only recent article which less than 5 year publication included in this study. RE-COVER study showed non-inferiority of dabigatran as compare to warfarin in treating DVT patients. Mortality rate and recurrent rate of DVT were 2.4% vs. 2.1% in dabigatran and warfarin respectively (HR=1,10 CI 95% = 0,65-1,84). Dabigatran showed less bleeding rate compare to warfarin, 5.6% vs. 8.8% respectively (HR = 0,63 CI95% = 0,47 - 0,84; RRR =29%, p = 0,0002). Similar results is shown in EINSTEIN study that compares rivaroxaban with warfarin. Mortality rate and recurrent rate of DVT were 2.1% vs. 3% in rivaroxaban and warfarin respectively (HR=0,68 CI 95% = 0,44-1,04). Total bleeding rate were 7.3% vs. 7% and major bleeding were 0.8% vs. 1.2% in rivaroxaban and warfarin respectively. Conclusion. Both dabigatran and rivaroxaban showed non inferior efficacy as compare to warfarin in the treatment of DVT, and slightly better bleeding rate.http://ijconline.id/index.php/ijc/article/view/31deep vein thrombosisantikoagulan oral barudabigatranrivaroxabanefikasikeamanan |
| spellingShingle | Ridwan Rasyid Pringgodigdo Nugroho Yoga Yuniadi Review on Efficacy and Safety of Newer Oral Anticoagulants for Deep Vein Thrombosis Patient Majalah Kardiologi Indonesia deep vein thrombosis antikoagulan oral baru dabigatran rivaroxaban efikasi keamanan |
| title | Review on Efficacy and Safety of Newer Oral Anticoagulants for Deep Vein Thrombosis Patient |
| title_full | Review on Efficacy and Safety of Newer Oral Anticoagulants for Deep Vein Thrombosis Patient |
| title_fullStr | Review on Efficacy and Safety of Newer Oral Anticoagulants for Deep Vein Thrombosis Patient |
| title_full_unstemmed | Review on Efficacy and Safety of Newer Oral Anticoagulants for Deep Vein Thrombosis Patient |
| title_short | Review on Efficacy and Safety of Newer Oral Anticoagulants for Deep Vein Thrombosis Patient |
| title_sort | review on efficacy and safety of newer oral anticoagulants for deep vein thrombosis patient |
| topic | deep vein thrombosis antikoagulan oral baru dabigatran rivaroxaban efikasi keamanan |
| url | http://ijconline.id/index.php/ijc/article/view/31 |
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