Mutation Frequency in Main Susceptibility Genes Among Patients With Head and Neck Paragangliomas

Mutation Frequency in Main Susceptibility Genes Among Patients With Head and Neck Paragangliomas

Head and neck paragangliomas (HNPGLs) are rare neuroendocrine tumors that have a high degree of heritability and are predominantly associated with mutations in ten genes, such as SDHx, SDHAF2, VHL, RET, NF1, TMEM127, MAX, FH, MEN2, and SLC25A11. Elucidating the mutation prevalence is crucial for the...

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Main Authors: Anastasiya V. Snezhkina, Maria S. Fedorova, Vladislav S. Pavlov, Dmitry V. Kalinin, Alexander L. Golovyuk, Elena A. Pudova, Zulfiya G. Guvatova, Nataliya V. Melnikova, Alexey A. Dmitriev, George S. Razmakhaev, Andrey A. Poloznikov, Galina S. Alekseeva, Andrey D. Kaprin, George S. Krasnov, Anna V. Kudryavtseva
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Genetics
Subjects:
head and neck paragangliomas
carotid and vagal paragangliomas
susceptibility genes
SDHx
mutation frequency
pathogenic mutations
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2020.614908/full

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