Incursions by severe acute respiratory syndrome coronavirus-2 on the host anti-viral immunity during mild, moderate, and severe coronavirus disease 2019 disease
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in the human host can lead to various clinical manifestations, from symptomless carriers to mild to moderate to severe/critical illness. Therefore, the clinical classification of SARS-CoV-2 disease, based on severity, is a re...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Open Exploration Publishing Inc.
2022-12-01
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| Series: | Exploration of Immunology |
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| Online Access: | https://www.explorationpub.com/Journals/ei/Article/100384 |
| _version_ | 1797894841359663104 |
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| author | Nitin Saksena Srinivasa R. Bonam Monica Miranda-Saksena Thyago H. Cardoso |
| author_facet | Nitin Saksena Srinivasa R. Bonam Monica Miranda-Saksena Thyago H. Cardoso |
| author_sort | Nitin Saksena |
| collection | DOAJ |
| description | The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in the human host can lead to various clinical manifestations, from symptomless carriers to mild to moderate to severe/critical illness. Therefore, the clinical classification of SARS-CoV-2 disease, based on severity, is a reliable way to predict disease states in SARS-CoV-2 infection. Recent studies on genomics, transcriptomics, epigenomics, and immunogenomics, along with spatial analysis of immune cells have delineated and defined the categorization of these disease groups using these high throughout technologies. These technologies hold the promise of providing not only a detailed but a holistic view of SARS-CoV-2-led pathogenesis. The main genomic, cellular, and immunologic features of each disease category, and what separates them spatially and molecularly are discussed in this brief review to provide a foundational spatial understanding of SARS-CoV-2 immunopathogenesis. |
| first_indexed | 2024-04-10T07:15:48Z |
| format | Article |
| id | doaj.art-0984e5ecf68d49d8bdbdaf69b522e778 |
| institution | Directory Open Access Journal |
| issn | 2768-6655 |
| language | English |
| last_indexed | 2024-04-10T07:15:48Z |
| publishDate | 2022-12-01 |
| publisher | Open Exploration Publishing Inc. |
| record_format | Article |
| series | Exploration of Immunology |
| spelling | doaj.art-0984e5ecf68d49d8bdbdaf69b522e7782023-02-25T07:28:10ZengOpen Exploration Publishing Inc.Exploration of Immunology2768-66552022-12-012679481110.37349/ei.2022.00084Incursions by severe acute respiratory syndrome coronavirus-2 on the host anti-viral immunity during mild, moderate, and severe coronavirus disease 2019 diseaseNitin Saksena0https://orcid.org/0000-0002-2431-9871Srinivasa R. Bonam1https://orcid.org/0000-0002-2888-2418Monica Miranda-Saksena2https://orcid.org/0000-0002-4868-9789Thyago H. Cardoso3https://orcid.org/0000-0002-4620-6579Institute for Health and Sport, Victoria University, Footscray Campus, Melbourne VIC. 3011, Australia; Aegros Therapeutics Pty Ltd, Macquarie Park, Sydney 2019, AustraliaDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USAWestmead Institute of Medical Research (WIMR), Herpes Virus Laboratory, Sydney 2145, AustraliaOMICS Centre of Excellence, G42 Healthcare, Mazdar City, Abu Dhabi 3079, United Arab EmiratesThe severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in the human host can lead to various clinical manifestations, from symptomless carriers to mild to moderate to severe/critical illness. Therefore, the clinical classification of SARS-CoV-2 disease, based on severity, is a reliable way to predict disease states in SARS-CoV-2 infection. Recent studies on genomics, transcriptomics, epigenomics, and immunogenomics, along with spatial analysis of immune cells have delineated and defined the categorization of these disease groups using these high throughout technologies. These technologies hold the promise of providing not only a detailed but a holistic view of SARS-CoV-2-led pathogenesis. The main genomic, cellular, and immunologic features of each disease category, and what separates them spatially and molecularly are discussed in this brief review to provide a foundational spatial understanding of SARS-CoV-2 immunopathogenesis.https://www.explorationpub.com/Journals/ei/Article/100384severe acute respiratory syndrome coronavirus-2anti-viral immunitygenomicsinterferonsimmune cellstropism |
| spellingShingle | Nitin Saksena Srinivasa R. Bonam Monica Miranda-Saksena Thyago H. Cardoso Incursions by severe acute respiratory syndrome coronavirus-2 on the host anti-viral immunity during mild, moderate, and severe coronavirus disease 2019 disease Exploration of Immunology severe acute respiratory syndrome coronavirus-2 anti-viral immunity genomics interferons immune cells tropism |
| title | Incursions by severe acute respiratory syndrome coronavirus-2 on the host anti-viral immunity during mild, moderate, and severe coronavirus disease 2019 disease |
| title_full | Incursions by severe acute respiratory syndrome coronavirus-2 on the host anti-viral immunity during mild, moderate, and severe coronavirus disease 2019 disease |
| title_fullStr | Incursions by severe acute respiratory syndrome coronavirus-2 on the host anti-viral immunity during mild, moderate, and severe coronavirus disease 2019 disease |
| title_full_unstemmed | Incursions by severe acute respiratory syndrome coronavirus-2 on the host anti-viral immunity during mild, moderate, and severe coronavirus disease 2019 disease |
| title_short | Incursions by severe acute respiratory syndrome coronavirus-2 on the host anti-viral immunity during mild, moderate, and severe coronavirus disease 2019 disease |
| title_sort | incursions by severe acute respiratory syndrome coronavirus 2 on the host anti viral immunity during mild moderate and severe coronavirus disease 2019 disease |
| topic | severe acute respiratory syndrome coronavirus-2 anti-viral immunity genomics interferons immune cells tropism |
| url | https://www.explorationpub.com/Journals/ei/Article/100384 |
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