Codon Deviation Coefficient: a novel measure for estimating codon usage bias and its statistical significance

Codon Deviation Coefficient: a novel measure for estimating codon usage bias and its statistical significance

<p>Abstract</p> <p>Background</p> <p>Genetic mutation, selective pressure for translational efficiency and accuracy, level of gene expression, and protein function through natural selection are all believed to lead to codon usage bias (CUB). Therefore, informative measu...

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Bibliographic Details
Main Authors: Zhang Zhang, Li Jun, Cui Peng, Ding Feng, Li Ang, Townsend Jeffrey P, Yu Jun
Format: Article
Language:English
Published: BMC 2012-03-01
Series:BMC Bioinformatics
Subjects:
Codon deviation coefficient
CDC
Codon usage bias
CUB
Statistical significance
Background nucleotide composition
GC content
Purine content
Bootstrapping
Online Access:http://www.biomedcentral.com/1471-2105/13/43

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