Association between Lys198Asn polymorphism of endothelin‐1 gene and ischemic stroke: A meta‐analysis
Abstract Background Endothelin (ET)‐1 is a potent vasoconstrictor peptide produced by endothelial cells and associated with vascular dysfunction and cardiovascular disease. Lys198Asn is a single‐nucleotide polymorphism (SNP) of gene encoding ET‐1 (EDN1). It is hypothesized that it might have a role...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-10-01
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| Series: | Brain and Behavior |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/brb3.1424 |
| _version_ | 1818262128001286144 |
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| author | Gaurav Nepal Rajeev Ojha Hari Prasad Dulal Binod Kumar Yadav |
| author_facet | Gaurav Nepal Rajeev Ojha Hari Prasad Dulal Binod Kumar Yadav |
| author_sort | Gaurav Nepal |
| collection | DOAJ |
| description | Abstract Background Endothelin (ET)‐1 is a potent vasoconstrictor peptide produced by endothelial cells and associated with vascular dysfunction and cardiovascular disease. Lys198Asn is a single‐nucleotide polymorphism (SNP) of gene encoding ET‐1 (EDN1). It is hypothesized that it might have a role in altering ET‐1 and ultimately leading to vascular dysfunction and ischemic stroke. We therefore conducted a meta‐analysis to investigate the association between Lys198Asn polymorphism of EDN1 gene and susceptibility of ischemic stroke. Methods This meta‐analysis was conducted according to the guidance of the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) statement. We searched PubMed, Google Scholar, Embase, Web of Science, J‐STAGE, and China National Knowledge Infrastructure (CNKI) for relevant studies. The association between Lys198Asn polymorphism and ischemic stroke susceptibility was evaluated by calculating the pooled ORs and 95% CIs. Results Our analysis included 1,291 cases and 2,513 controls. Meta‐analysis established a significant association between Lys198Asn SNP of EDN1 gene and ischemic stroke when assuming either recessive model (OR: 1.30; 95% CI: 1.02–1.65; p = .03; I2 = 41%) or dominant model (OR: 1.48; 95% CI: 1.24–1.76; p < .001; I2 = 61%). There was no evidence of publication bias in either of the recessive model (Egger test: p = .23; Begg test: p = .85) or dominant model (Egger test: p = .79; Begg test: p = .85). A subgroup analysis based on subtypes of ischemic stroke showed that Lys198Asn SNP was only associated with large vessel infarction but not with lacunar infarction caused by small vessel disease. A subgroup analysis based on ethnicity revealed that the Lys198Asn polymorphism of the EDN1 gene was associated with ischemic stroke only in Caucasians. Conclusions The present meta‐analysis suggests that Lys198Asn polymorphism of EDN1 gene is associated with an increased risk for ischemic stroke. |
| first_indexed | 2024-12-12T18:58:11Z |
| format | Article |
| id | doaj.art-0988618c435b4029bac1c0c27aac39a5 |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-12-12T18:58:11Z |
| publishDate | 2019-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-0988618c435b4029bac1c0c27aac39a52022-12-22T00:15:10ZengWileyBrain and Behavior2162-32792019-10-01910n/an/a10.1002/brb3.1424Association between Lys198Asn polymorphism of endothelin‐1 gene and ischemic stroke: A meta‐analysisGaurav Nepal0Rajeev Ojha1Hari Prasad Dulal2Binod Kumar Yadav3Maharajgunj Medical Campus Tribhuvan University Institute of Medicine Kathmandu NepalDepartment of Neurology Maharajgunj Medical Campus Tribhuvan University Institute of Medicine Kathmandu NepalDepartment of Biochemistry Chitwan Medical College Bharatpur NepalDepartment of Biochemistry Maharajgunj Medical Campus Tribhuvan University Institute of Medicine Kathmandu NepalAbstract Background Endothelin (ET)‐1 is a potent vasoconstrictor peptide produced by endothelial cells and associated with vascular dysfunction and cardiovascular disease. Lys198Asn is a single‐nucleotide polymorphism (SNP) of gene encoding ET‐1 (EDN1). It is hypothesized that it might have a role in altering ET‐1 and ultimately leading to vascular dysfunction and ischemic stroke. We therefore conducted a meta‐analysis to investigate the association between Lys198Asn polymorphism of EDN1 gene and susceptibility of ischemic stroke. Methods This meta‐analysis was conducted according to the guidance of the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) statement. We searched PubMed, Google Scholar, Embase, Web of Science, J‐STAGE, and China National Knowledge Infrastructure (CNKI) for relevant studies. The association between Lys198Asn polymorphism and ischemic stroke susceptibility was evaluated by calculating the pooled ORs and 95% CIs. Results Our analysis included 1,291 cases and 2,513 controls. Meta‐analysis established a significant association between Lys198Asn SNP of EDN1 gene and ischemic stroke when assuming either recessive model (OR: 1.30; 95% CI: 1.02–1.65; p = .03; I2 = 41%) or dominant model (OR: 1.48; 95% CI: 1.24–1.76; p < .001; I2 = 61%). There was no evidence of publication bias in either of the recessive model (Egger test: p = .23; Begg test: p = .85) or dominant model (Egger test: p = .79; Begg test: p = .85). A subgroup analysis based on subtypes of ischemic stroke showed that Lys198Asn SNP was only associated with large vessel infarction but not with lacunar infarction caused by small vessel disease. A subgroup analysis based on ethnicity revealed that the Lys198Asn polymorphism of the EDN1 gene was associated with ischemic stroke only in Caucasians. Conclusions The present meta‐analysis suggests that Lys198Asn polymorphism of EDN1 gene is associated with an increased risk for ischemic stroke.https://doi.org/10.1002/brb3.1424cerebral infarctionEDN1endothelin‐1ischemic strokeK198NLys198Asn |
| spellingShingle | Gaurav Nepal Rajeev Ojha Hari Prasad Dulal Binod Kumar Yadav Association between Lys198Asn polymorphism of endothelin‐1 gene and ischemic stroke: A meta‐analysis Brain and Behavior cerebral infarction EDN1 endothelin‐1 ischemic stroke K198N Lys198Asn |
| title | Association between Lys198Asn polymorphism of endothelin‐1 gene and ischemic stroke: A meta‐analysis |
| title_full | Association between Lys198Asn polymorphism of endothelin‐1 gene and ischemic stroke: A meta‐analysis |
| title_fullStr | Association between Lys198Asn polymorphism of endothelin‐1 gene and ischemic stroke: A meta‐analysis |
| title_full_unstemmed | Association between Lys198Asn polymorphism of endothelin‐1 gene and ischemic stroke: A meta‐analysis |
| title_short | Association between Lys198Asn polymorphism of endothelin‐1 gene and ischemic stroke: A meta‐analysis |
| title_sort | association between lys198asn polymorphism of endothelin 1 gene and ischemic stroke a meta analysis |
| topic | cerebral infarction EDN1 endothelin‐1 ischemic stroke K198N Lys198Asn |
| url | https://doi.org/10.1002/brb3.1424 |
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