Sanghuangporus sanghuang extract extended the lifespan and healthspan of Caenorhabditis elegans via DAF-16/SIR-2.1
Sanghuangporus Sanghuang is a fungus species. As a traditional Chinese medicine, it is known for antitumor, antioxidant and anti-inflammatory properties. However, the antiaging effect of S. Sanghuang has not been deeply studied. In this study, the effects of S. Sanghuang extract (SSE) supernatants o...
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| Format: | Article |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1136897/full |
| _version_ | 1827963806278483968 |
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| author | Zhenghan Dong Zhenghan Dong Yachao Wang Yachao Wang Cuiting Hao Cuiting Hao Yuan Cheng Yuan Cheng Xi Guo Xi Guo Yanyu He Yanyu He Yueyue Shi Yueyue Shi Shuang Wang Shuang Wang Yunqi Li Yunqi Li Wei Shi Wei Shi |
| author_facet | Zhenghan Dong Zhenghan Dong Yachao Wang Yachao Wang Cuiting Hao Cuiting Hao Yuan Cheng Yuan Cheng Xi Guo Xi Guo Yanyu He Yanyu He Yueyue Shi Yueyue Shi Shuang Wang Shuang Wang Yunqi Li Yunqi Li Wei Shi Wei Shi |
| author_sort | Zhenghan Dong |
| collection | DOAJ |
| description | Sanghuangporus Sanghuang is a fungus species. As a traditional Chinese medicine, it is known for antitumor, antioxidant and anti-inflammatory properties. However, the antiaging effect of S. Sanghuang has not been deeply studied. In this study, the effects of S. Sanghuang extract (SSE) supernatants on the changes of nematode indicators were investigated. The results showed that different concentrations of SSE prolonged the lifespans of nematodes and substantially increased these by 26.41%. In addition, accumulations of lipofuscin were also visibly reduced. The treatment using SSE also played a role in increasing stress resistance, decreasing ROS accumulations and obesity, and enhancing the physique. RT–PCR analysis showed that the SSE treatment upregulated the transcription of daf-16, sir-2.1, daf-2, sod-3 and hsp-16.2, increased the expression of these genes in the insulin/IGF-1 signalling pathway and prolonged the lifespans of nematodes. This study reveals the new role of S. Sanghuang in promoting longevity and inhibiting stress and provides a theoretical basis for the application of S. Sanghuang in anti-ageing treatments. |
| first_indexed | 2024-04-09T17:04:55Z |
| format | Article |
| id | doaj.art-098942d52d42448593d4b462a76fce8f |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-09T17:04:55Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-098942d52d42448593d4b462a76fce8f2023-04-20T17:37:12ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-04-011410.3389/fphar.2023.11368971136897Sanghuangporus sanghuang extract extended the lifespan and healthspan of Caenorhabditis elegans via DAF-16/SIR-2.1Zhenghan Dong0Zhenghan Dong1Yachao Wang2Yachao Wang3Cuiting Hao4Cuiting Hao5Yuan Cheng6Yuan Cheng7Xi Guo8Xi Guo9Yanyu He10Yanyu He11Yueyue Shi12Yueyue Shi13Shuang Wang14Shuang Wang15Yunqi Li16Yunqi Li17Wei Shi18Wei Shi19Key Laboratory for Molecular Enzymology and Engineering, The Ministry of Education, Jilin University, Changchun, Jilin, ChinaCollege of Life Sciences, Jilin University, Changchun, Jilin, ChinaKey Laboratory for Molecular Enzymology and Engineering, The Ministry of Education, Jilin University, Changchun, Jilin, ChinaCollege of Life Sciences, Jilin University, Changchun, Jilin, ChinaKey Laboratory for Molecular Enzymology and Engineering, The Ministry of Education, Jilin University, Changchun, Jilin, ChinaCollege of Life Sciences, Jilin University, Changchun, Jilin, ChinaKey Laboratory for Molecular Enzymology and Engineering, The Ministry of Education, Jilin University, Changchun, Jilin, ChinaCollege of Life Sciences, Jilin University, Changchun, Jilin, ChinaKey Laboratory for Molecular Enzymology and Engineering, The Ministry of Education, Jilin University, Changchun, Jilin, ChinaCollege of Life Sciences, Jilin University, Changchun, Jilin, ChinaKey Laboratory for Molecular Enzymology and Engineering, The Ministry of Education, Jilin University, Changchun, Jilin, ChinaCollege of Life Sciences, Jilin University, Changchun, Jilin, ChinaKey Laboratory for Molecular Enzymology and Engineering, The Ministry of Education, Jilin University, Changchun, Jilin, ChinaCollege of Life Sciences, Jilin University, Changchun, Jilin, ChinaKey Laboratory for Molecular Enzymology and Engineering, The Ministry of Education, Jilin University, Changchun, Jilin, ChinaCollege of Life Sciences, Jilin University, Changchun, Jilin, ChinaKey Laboratory for Molecular Enzymology and Engineering, The Ministry of Education, Jilin University, Changchun, Jilin, ChinaCollege of Life Sciences, Jilin University, Changchun, Jilin, ChinaKey Laboratory for Molecular Enzymology and Engineering, The Ministry of Education, Jilin University, Changchun, Jilin, ChinaCollege of Life Sciences, Jilin University, Changchun, Jilin, ChinaSanghuangporus Sanghuang is a fungus species. As a traditional Chinese medicine, it is known for antitumor, antioxidant and anti-inflammatory properties. However, the antiaging effect of S. Sanghuang has not been deeply studied. In this study, the effects of S. Sanghuang extract (SSE) supernatants on the changes of nematode indicators were investigated. The results showed that different concentrations of SSE prolonged the lifespans of nematodes and substantially increased these by 26.41%. In addition, accumulations of lipofuscin were also visibly reduced. The treatment using SSE also played a role in increasing stress resistance, decreasing ROS accumulations and obesity, and enhancing the physique. RT–PCR analysis showed that the SSE treatment upregulated the transcription of daf-16, sir-2.1, daf-2, sod-3 and hsp-16.2, increased the expression of these genes in the insulin/IGF-1 signalling pathway and prolonged the lifespans of nematodes. This study reveals the new role of S. Sanghuang in promoting longevity and inhibiting stress and provides a theoretical basis for the application of S. Sanghuang in anti-ageing treatments.https://www.frontiersin.org/articles/10.3389/fphar.2023.1136897/fullSanghuangporus sanghuangantiagingCaenorhabditis elegansantistressdaf-16sir-2.1 |
| spellingShingle | Zhenghan Dong Zhenghan Dong Yachao Wang Yachao Wang Cuiting Hao Cuiting Hao Yuan Cheng Yuan Cheng Xi Guo Xi Guo Yanyu He Yanyu He Yueyue Shi Yueyue Shi Shuang Wang Shuang Wang Yunqi Li Yunqi Li Wei Shi Wei Shi Sanghuangporus sanghuang extract extended the lifespan and healthspan of Caenorhabditis elegans via DAF-16/SIR-2.1 Frontiers in Pharmacology Sanghuangporus sanghuang antiaging Caenorhabditis elegans antistress daf-16 sir-2.1 |
| title | Sanghuangporus sanghuang extract extended the lifespan and healthspan of Caenorhabditis elegans via DAF-16/SIR-2.1 |
| title_full | Sanghuangporus sanghuang extract extended the lifespan and healthspan of Caenorhabditis elegans via DAF-16/SIR-2.1 |
| title_fullStr | Sanghuangporus sanghuang extract extended the lifespan and healthspan of Caenorhabditis elegans via DAF-16/SIR-2.1 |
| title_full_unstemmed | Sanghuangporus sanghuang extract extended the lifespan and healthspan of Caenorhabditis elegans via DAF-16/SIR-2.1 |
| title_short | Sanghuangporus sanghuang extract extended the lifespan and healthspan of Caenorhabditis elegans via DAF-16/SIR-2.1 |
| title_sort | sanghuangporus sanghuang extract extended the lifespan and healthspan of caenorhabditis elegans via daf 16 sir 2 1 |
| topic | Sanghuangporus sanghuang antiaging Caenorhabditis elegans antistress daf-16 sir-2.1 |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1136897/full |
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