Processing speed impairment in chronic inflammatory demyelinating polyneuropathy patients: a cross-sectional study
Background There is a lack of evidence of cognitive involvement in chronic inflammatory demyelinating polyneuropathy (CIDP) and, the reports about the involvement of the brain and central nervous system (CNS) are few and controversial. The Five Digit Test (FDT) evaluates processing speed (PS) and ex...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Academia Brasileira de Neurologia (ABNEURO)
2022-10-01
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| Series: | Arquivos de Neuro-Psiquiatria |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1758557 |
| _version_ | 1798004769990639616 |
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| author | Iara Senem Carina Telarolli Spedo Rodrigo Melo Conde Geraldo Cassio dos Reis Antônio Carlos dos Santos Amilton Antunes Barreira Wilson Marques Jr |
| author_facet | Iara Senem Carina Telarolli Spedo Rodrigo Melo Conde Geraldo Cassio dos Reis Antônio Carlos dos Santos Amilton Antunes Barreira Wilson Marques Jr |
| author_sort | Iara Senem |
| collection | DOAJ |
| description | Background There is a lack of evidence of cognitive involvement in chronic inflammatory demyelinating polyneuropathy (CIDP) and, the reports about the involvement of the brain and central nervous system (CNS) are few and controversial. The Five Digit Test (FDT) evaluates processing speed (PS) and executive functions orally.
Objective To evaluate the performance on the FDT of CIDP patients with and without CNS (brain/cerebellum) alterations observed on brain Magnetic Resonance Imaging (MRI) scans.
Methods The Hospital Anxiety and Depression Scale (HADS, to assess neuropsychiatry symptoms), the Rasch-built Overall Disability Scale (R-ODS; to assess disability), and the FDT (to assess cognition) were applied to 14 CIDP patients and 24 age-matched healthy control subjects. The patients were submitted to routine brain MRI and, according to the results, they were divided into two groups: those with abnormalities on the MRI (CIDPabnl) and those with normal parameters on the MRI (CIDPnl). The FDT data of five CIDPnl patients and nine CIDPabnl subjects were analyzed. Comparisons between the groups were performed for each task of the FDT.
Results We found statistical differences for both groups of CIDP patients in terms of PS, for the patients spent more time performing the PS tasks than the controls. The PS measures were negatively associated with disability scores (reading: r = −0.47; p = 0.003; counting: r = −0.53; p = 0.001).
Conclusions Our data suggested the presence of PS impairment in CIDP patients. Disability was associated with slow PS. |
| first_indexed | 2024-04-11T12:28:40Z |
| format | Article |
| id | doaj.art-09895dc78db847ba9ff1fb1b564aea41 |
| institution | Directory Open Access Journal |
| issn | 0004-282X 1678-4227 |
| language | English |
| last_indexed | 2024-04-11T12:28:40Z |
| publishDate | 2022-10-01 |
| publisher | Academia Brasileira de Neurologia (ABNEURO) |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj.art-09895dc78db847ba9ff1fb1b564aea412022-12-22T04:23:50ZengAcademia Brasileira de Neurologia (ABNEURO)Arquivos de Neuro-Psiquiatria0004-282X1678-42272022-10-0180101036104410.1055/s-0042-1758557Processing speed impairment in chronic inflammatory demyelinating polyneuropathy patients: a cross-sectional studyIara Senem0Carina Telarolli Spedo1Rodrigo Melo Conde2Geraldo Cassio dos Reis3Antônio Carlos dos Santos4Amilton Antunes Barreira5Wilson Marques Jr6Universidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Departamento de Neurociências e Ciências do Comportamento, Ribeirão Preto SP, Brazil.Universidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Departamento de Neurociências e Ciências do Comportamento, Ribeirão Preto SP, Brazil.Universidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Departamento de Neurociências e Ciências do Comportamento, Ribeirão Preto SP, Brazil.Universidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Departamento de Neurociências e Ciências do Comportamento, Ribeirão Preto SP, Brazil.Universidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Departamento de Neurociências e Ciências do Comportamento, Ribeirão Preto SP, Brazil.Universidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Departamento de Neurociências e Ciências do Comportamento, Ribeirão Preto SP, Brazil.Universidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Departamento de Neurociências e Ciências do Comportamento, Ribeirão Preto SP, Brazil.Background There is a lack of evidence of cognitive involvement in chronic inflammatory demyelinating polyneuropathy (CIDP) and, the reports about the involvement of the brain and central nervous system (CNS) are few and controversial. The Five Digit Test (FDT) evaluates processing speed (PS) and executive functions orally. Objective To evaluate the performance on the FDT of CIDP patients with and without CNS (brain/cerebellum) alterations observed on brain Magnetic Resonance Imaging (MRI) scans. Methods The Hospital Anxiety and Depression Scale (HADS, to assess neuropsychiatry symptoms), the Rasch-built Overall Disability Scale (R-ODS; to assess disability), and the FDT (to assess cognition) were applied to 14 CIDP patients and 24 age-matched healthy control subjects. The patients were submitted to routine brain MRI and, according to the results, they were divided into two groups: those with abnormalities on the MRI (CIDPabnl) and those with normal parameters on the MRI (CIDPnl). The FDT data of five CIDPnl patients and nine CIDPabnl subjects were analyzed. Comparisons between the groups were performed for each task of the FDT. Results We found statistical differences for both groups of CIDP patients in terms of PS, for the patients spent more time performing the PS tasks than the controls. The PS measures were negatively associated with disability scores (reading: r = −0.47; p = 0.003; counting: r = −0.53; p = 0.001). Conclusions Our data suggested the presence of PS impairment in CIDP patients. Disability was associated with slow PS.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1758557polyradiculoneuropathy, chronic inflammatory demyelinatingcognitionexecutive function |
| spellingShingle | Iara Senem Carina Telarolli Spedo Rodrigo Melo Conde Geraldo Cassio dos Reis Antônio Carlos dos Santos Amilton Antunes Barreira Wilson Marques Jr Processing speed impairment in chronic inflammatory demyelinating polyneuropathy patients: a cross-sectional study Arquivos de Neuro-Psiquiatria polyradiculoneuropathy, chronic inflammatory demyelinating cognition executive function |
| title | Processing speed impairment in chronic inflammatory demyelinating polyneuropathy patients: a cross-sectional study |
| title_full | Processing speed impairment in chronic inflammatory demyelinating polyneuropathy patients: a cross-sectional study |
| title_fullStr | Processing speed impairment in chronic inflammatory demyelinating polyneuropathy patients: a cross-sectional study |
| title_full_unstemmed | Processing speed impairment in chronic inflammatory demyelinating polyneuropathy patients: a cross-sectional study |
| title_short | Processing speed impairment in chronic inflammatory demyelinating polyneuropathy patients: a cross-sectional study |
| title_sort | processing speed impairment in chronic inflammatory demyelinating polyneuropathy patients a cross sectional study |
| topic | polyradiculoneuropathy, chronic inflammatory demyelinating cognition executive function |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1758557 |
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