The Effect of Milk Thistle Extract in the Treatment of Diabetic Nephropathy
Background: Milk thistle has antioxidative effects and may improve renal performance. Our study investigated whether Milk thistle improve renal performance in patients with type II diabetes mellitus nephropathy. Methods: In this clinical trial study, after ethics committee approval, 65 Patients with...
| Main Authors: | , , |
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| Format: | Article |
| Language: | fas |
| Published: |
Isfahan University of Medical Sciences
2011-04-01
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| Series: | مجله دانشکده پزشکی اصفهان |
| Subjects: | |
| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/888 |
| Summary: | Background: Milk thistle has antioxidative effects and may improve renal performance. Our study investigated whether Milk thistle improve renal performance in patients with type II diabetes mellitus nephropathy.
Methods: In this clinical trial study, after ethics committee approval, 65 Patients with type II diabetes mellitus were enrolled into a randomized simple sampling, prospective, double-blinded study. In the case group, was gave Milk thistle and control group was given placebo. We measured urine albumin/cratinine (A/C) ratio and eGFR before and after intervention. The gathered data were analyzed by t and paired-t tests. P < 0.05 was regarded as significant level.
Finding: The groups were well matched for age, sex, and duration of diabetes. The mean age was 55.9 ± 6.5 and 57.7 ± 7.7 years in case and control groups, respectively. There was not any significant difference between A/C ratio in case and control groups after intervention (P > 0.05); but in case group, after intervention A/C ratio was worse than before it (P < 0.05).
Conclusion: The results suggest that Milk thistle did not improve the renal performance in patients with type II diabetes mellitus. |
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| ISSN: | 1027-7595 1735-854X |