The Effect of Milk Thistle Extract in the Treatment of Diabetic Nephropathy
Background: Milk thistle has antioxidative effects and may improve renal performance. Our study investigated whether Milk thistle improve renal performance in patients with type II diabetes mellitus nephropathy. Methods: In this clinical trial study, after ethics committee approval, 65 Patients with...
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| Format: | Article |
| Language: | fas |
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Isfahan University of Medical Sciences
2011-04-01
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| Series: | مجله دانشکده پزشکی اصفهان |
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| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/888 |
| _version_ | 1797758746345078784 |
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| author | Hassan Rezvanian Ali Kachuei Ali Mirzapour |
| author_facet | Hassan Rezvanian Ali Kachuei Ali Mirzapour |
| author_sort | Hassan Rezvanian |
| collection | DOAJ |
| description | Background: Milk thistle has antioxidative effects and may improve renal performance. Our study investigated whether Milk thistle improve renal performance in patients with type II diabetes mellitus nephropathy.
Methods: In this clinical trial study, after ethics committee approval, 65 Patients with type II diabetes mellitus were enrolled into a randomized simple sampling, prospective, double-blinded study. In the case group, was gave Milk thistle and control group was given placebo. We measured urine albumin/cratinine (A/C) ratio and eGFR before and after intervention. The gathered data were analyzed by t and paired-t tests. P < 0.05 was regarded as significant level.
Finding: The groups were well matched for age, sex, and duration of diabetes. The mean age was 55.9 ± 6.5 and 57.7 ± 7.7 years in case and control groups, respectively. There was not any significant difference between A/C ratio in case and control groups after intervention (P > 0.05); but in case group, after intervention A/C ratio was worse than before it (P < 0.05).
Conclusion: The results suggest that Milk thistle did not improve the renal performance in patients with type II diabetes mellitus. |
| first_indexed | 2024-03-12T18:34:34Z |
| format | Article |
| id | doaj.art-098acba31ddf4d6c89623dda83361ee4 |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T18:34:34Z |
| publishDate | 2011-04-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-098acba31ddf4d6c89623dda83361ee42023-08-02T08:04:27ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2011-04-012812419972010603The Effect of Milk Thistle Extract in the Treatment of Diabetic NephropathyHassan Rezvanian0Ali Kachuei1Ali Mirzapour2Asociate Professor, Deartment of Endocrinology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranAsociate Professor, Deartment of Endocrinology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranMedical Student, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.Background: Milk thistle has antioxidative effects and may improve renal performance. Our study investigated whether Milk thistle improve renal performance in patients with type II diabetes mellitus nephropathy. Methods: In this clinical trial study, after ethics committee approval, 65 Patients with type II diabetes mellitus were enrolled into a randomized simple sampling, prospective, double-blinded study. In the case group, was gave Milk thistle and control group was given placebo. We measured urine albumin/cratinine (A/C) ratio and eGFR before and after intervention. The gathered data were analyzed by t and paired-t tests. P < 0.05 was regarded as significant level. Finding: The groups were well matched for age, sex, and duration of diabetes. The mean age was 55.9 ± 6.5 and 57.7 ± 7.7 years in case and control groups, respectively. There was not any significant difference between A/C ratio in case and control groups after intervention (P > 0.05); but in case group, after intervention A/C ratio was worse than before it (P < 0.05). Conclusion: The results suggest that Milk thistle did not improve the renal performance in patients with type II diabetes mellitus.http://jims.mui.ac.ir/index.php/jims/article/view/888Milk thistleDiabetic nephropathyTreatmentRenal performance |
| spellingShingle | Hassan Rezvanian Ali Kachuei Ali Mirzapour The Effect of Milk Thistle Extract in the Treatment of Diabetic Nephropathy مجله دانشکده پزشکی اصفهان Milk thistle Diabetic nephropathy Treatment Renal performance |
| title | The Effect of Milk Thistle Extract in the Treatment of Diabetic Nephropathy |
| title_full | The Effect of Milk Thistle Extract in the Treatment of Diabetic Nephropathy |
| title_fullStr | The Effect of Milk Thistle Extract in the Treatment of Diabetic Nephropathy |
| title_full_unstemmed | The Effect of Milk Thistle Extract in the Treatment of Diabetic Nephropathy |
| title_short | The Effect of Milk Thistle Extract in the Treatment of Diabetic Nephropathy |
| title_sort | effect of milk thistle extract in the treatment of diabetic nephropathy |
| topic | Milk thistle Diabetic nephropathy Treatment Renal performance |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/888 |
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