Bioassay-Guided Isolation of Antiproliferative Compounds from <i>Limbarda crithmoides</i> (L.) Dumort
<i>Limbarda crithmoides</i> (L.) Dumort (Asteraceae) <i>n</i>-hexane extract displayed high cell proliferation inhibitory activity against acute myeloid leukaemia cells (OCI-AML3) and was therefore subjected to a bioassay-guided multistep separation procedure. Two thymol deri...
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| Format: | Article |
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MDPI AG
2020-04-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/8/1893 |
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| author | Sabrina Adorisio Laura Giamperi Anahi Elena Ada Bucchini Domenico Vittorio Delfino Maria Carla Marcotullio |
| author_facet | Sabrina Adorisio Laura Giamperi Anahi Elena Ada Bucchini Domenico Vittorio Delfino Maria Carla Marcotullio |
| author_sort | Sabrina Adorisio |
| collection | DOAJ |
| description | <i>Limbarda crithmoides</i> (L.) Dumort (Asteraceae) <i>n</i>-hexane extract displayed high cell proliferation inhibitory activity against acute myeloid leukaemia cells (OCI-AML3) and was therefore subjected to a bioassay-guided multistep separation procedure. Two thymol derivatives, namely 10-acetoxy-8,9-epoxythymol tiglate (<b>1</b>) and 10-acetoxy-9-chloro-8,9-dehydrothymol (<b>2</b>), were isolated and identified by means of NMR spectroscopy. Both of them exhibited a significant dose-dependent inhibition of cell proliferation. |
| first_indexed | 2024-03-10T20:20:53Z |
| format | Article |
| id | doaj.art-098bd27869bd44f8bca1eeefbb086df3 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T20:20:53Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-098bd27869bd44f8bca1eeefbb086df32023-11-19T22:08:40ZengMDPI AGMolecules1420-30492020-04-01258189310.3390/molecules25081893Bioassay-Guided Isolation of Antiproliferative Compounds from <i>Limbarda crithmoides</i> (L.) DumortSabrina Adorisio0Laura Giamperi1Anahi Elena Ada Bucchini2Domenico Vittorio Delfino3Maria Carla Marcotullio4Department of Medicine, Foligno Nursing School, University of Perugia, 06034 Foligno, ItalyDepartment of Biomolecular Sciences, Section of Biochemistry and Biotechnology, University of Urbino, 61029 Urbino, ItalyDepartment of Biomolecular Sciences, Section of Biochemistry and Biotechnology, University of Urbino, 61029 Urbino, ItalyDepartment of Medicine, Foligno Nursing School, University of Perugia, 06034 Foligno, ItalyDepartment of Pharmaceutical Sciences, Università degli Studi di Perugia, 06123 Perugia, Italy<i>Limbarda crithmoides</i> (L.) Dumort (Asteraceae) <i>n</i>-hexane extract displayed high cell proliferation inhibitory activity against acute myeloid leukaemia cells (OCI-AML3) and was therefore subjected to a bioassay-guided multistep separation procedure. Two thymol derivatives, namely 10-acetoxy-8,9-epoxythymol tiglate (<b>1</b>) and 10-acetoxy-9-chloro-8,9-dehydrothymol (<b>2</b>), were isolated and identified by means of NMR spectroscopy. Both of them exhibited a significant dose-dependent inhibition of cell proliferation.https://www.mdpi.com/1420-3049/25/8/1893<i>Inula crithmoides</i><i>Limbarda crithmoides</i>Asteraceaeantiproliferative activityOCI-AML3 |
| spellingShingle | Sabrina Adorisio Laura Giamperi Anahi Elena Ada Bucchini Domenico Vittorio Delfino Maria Carla Marcotullio Bioassay-Guided Isolation of Antiproliferative Compounds from <i>Limbarda crithmoides</i> (L.) Dumort Molecules <i>Inula crithmoides</i> <i>Limbarda crithmoides</i> Asteraceae antiproliferative activity OCI-AML3 |
| title | Bioassay-Guided Isolation of Antiproliferative Compounds from <i>Limbarda crithmoides</i> (L.) Dumort |
| title_full | Bioassay-Guided Isolation of Antiproliferative Compounds from <i>Limbarda crithmoides</i> (L.) Dumort |
| title_fullStr | Bioassay-Guided Isolation of Antiproliferative Compounds from <i>Limbarda crithmoides</i> (L.) Dumort |
| title_full_unstemmed | Bioassay-Guided Isolation of Antiproliferative Compounds from <i>Limbarda crithmoides</i> (L.) Dumort |
| title_short | Bioassay-Guided Isolation of Antiproliferative Compounds from <i>Limbarda crithmoides</i> (L.) Dumort |
| title_sort | bioassay guided isolation of antiproliferative compounds from i limbarda crithmoides i l dumort |
| topic | <i>Inula crithmoides</i> <i>Limbarda crithmoides</i> Asteraceae antiproliferative activity OCI-AML3 |
| url | https://www.mdpi.com/1420-3049/25/8/1893 |
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