Identification of a fatty acid Δ6-desaturase deficiency in human skin fibroblasts
Polyunsaturated fatty acid (PUFA) utilization was investigated in skin fibroblasts cultured from a female patient with an inherited abnormality in lipid metabolism. These deficient human skin fibroblasts (DF) converted 85–95% less [1-14C]linoleic acid (18:2n-6) to arachidonic acid (20:4n-6), 95% les...
Main Authors: | Deborah E. Williard, Joseph O. Nwankwo, Terry L. Kaduce, Shawn D. Harmon, Mira Irons, Hugo W. Moser, Gerald V. Raymond, Arthur A. Spector |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2001-04-01
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Series: | Journal of Lipid Research |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520303680 |
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