A Potential Mechanism of Sodium Channel Mediating the General Anesthesia Induced by Propofol

A Potential Mechanism of Sodium Channel Mediating the General Anesthesia Induced by Propofol

General anesthesia has revolutionized healthcare over the past 200 years and continues to show advancements. However, many phenomena induced by general anesthetics including paradoxical excitation are still poorly understood. Voltage-gated sodium channels (NaV) were believed to be one of the protein...

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Bibliographic Details
Main Authors: Jinglei Xiao, Zhengguo Chen, Buwei Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
propofol
voltage-gated sodium channels
Hodgkin–Huxley model
thalamocortical model
Hopf bifurcation
paradoxical excitation
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2020.593050/full

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