Advances in aptamer screening and aptasensors’ detection of heavy metal ions
Abstract Heavy metal pollution has become more and more serious with industrial development and resource exploitation. Because heavy metal ions are difficult to be biodegraded, they accumulate in the human body and cause serious threat to human health. However, the conventional methods to detect hea...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-06-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-021-00914-4 |
| _version_ | 1798042902599827456 |
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| author | Wenfei Guo Chuanxiang Zhang Tingting Ma Xueying Liu Zhu Chen Song Li Yan Deng |
| author_facet | Wenfei Guo Chuanxiang Zhang Tingting Ma Xueying Liu Zhu Chen Song Li Yan Deng |
| author_sort | Wenfei Guo |
| collection | DOAJ |
| description | Abstract Heavy metal pollution has become more and more serious with industrial development and resource exploitation. Because heavy metal ions are difficult to be biodegraded, they accumulate in the human body and cause serious threat to human health. However, the conventional methods to detect heavy metal ions are more strictly to the requirements by detection equipment, sample pretreatment, experimental environment, etc. Aptasensor has the advantages of strong specificity, high sensitivity and simple preparation to detect small molecules, which provides a new direction platform in the detection of heavy metal ions. This paper reviews the selection of aptamers as target for heavy metal ions since the 21th century and aptasensors application for detection of heavy metal ions that were reported in the past five years. Firstly, the selection methods for aptamers with high specificity and high affinity are introduced. Construction methods and research progress on sensor based aptamers as recognition element are also introduced systematically. Finally, the challenges and future opportunities of aptasensors in detecting heavy metal ions are discussed. |
| first_indexed | 2024-04-11T22:42:05Z |
| format | Article |
| id | doaj.art-09908812e7ec47a7b60b17cd09c52e9c |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-11T22:42:05Z |
| publishDate | 2021-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-09908812e7ec47a7b60b17cd09c52e9c2022-12-22T03:58:57ZengBMCJournal of Nanobiotechnology1477-31552021-06-0119111910.1186/s12951-021-00914-4Advances in aptamer screening and aptasensors’ detection of heavy metal ionsWenfei Guo0Chuanxiang Zhang1Tingting Ma2Xueying Liu3Zhu Chen4Song Li5Yan Deng6Hunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of TechnologyHunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of TechnologyHunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of TechnologyHunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of TechnologyHunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of TechnologyHunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of TechnologyHunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of TechnologyAbstract Heavy metal pollution has become more and more serious with industrial development and resource exploitation. Because heavy metal ions are difficult to be biodegraded, they accumulate in the human body and cause serious threat to human health. However, the conventional methods to detect heavy metal ions are more strictly to the requirements by detection equipment, sample pretreatment, experimental environment, etc. Aptasensor has the advantages of strong specificity, high sensitivity and simple preparation to detect small molecules, which provides a new direction platform in the detection of heavy metal ions. This paper reviews the selection of aptamers as target for heavy metal ions since the 21th century and aptasensors application for detection of heavy metal ions that were reported in the past five years. Firstly, the selection methods for aptamers with high specificity and high affinity are introduced. Construction methods and research progress on sensor based aptamers as recognition element are also introduced systematically. Finally, the challenges and future opportunities of aptasensors in detecting heavy metal ions are discussed.https://doi.org/10.1186/s12951-021-00914-4AptamerScreeningSELEXAptasensorHeavy metals ionDetection |
| spellingShingle | Wenfei Guo Chuanxiang Zhang Tingting Ma Xueying Liu Zhu Chen Song Li Yan Deng Advances in aptamer screening and aptasensors’ detection of heavy metal ions Journal of Nanobiotechnology Aptamer Screening SELEX Aptasensor Heavy metals ion Detection |
| title | Advances in aptamer screening and aptasensors’ detection of heavy metal ions |
| title_full | Advances in aptamer screening and aptasensors’ detection of heavy metal ions |
| title_fullStr | Advances in aptamer screening and aptasensors’ detection of heavy metal ions |
| title_full_unstemmed | Advances in aptamer screening and aptasensors’ detection of heavy metal ions |
| title_short | Advances in aptamer screening and aptasensors’ detection of heavy metal ions |
| title_sort | advances in aptamer screening and aptasensors detection of heavy metal ions |
| topic | Aptamer Screening SELEX Aptasensor Heavy metals ion Detection |
| url | https://doi.org/10.1186/s12951-021-00914-4 |
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