TIGAR-V2: Efficient TWAS tool with nonparametric Bayesian eQTL weights of 49 tissue types from GTEx V8

Summary: Standard transcriptome-wide association study (TWAS) methods first train gene expression prediction models using reference transcriptomic data and then test the association between the predicted genetically regulated gene expression and phenotype of interest. Most existing TWAS tools requir...

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Bibliographic Details
Main Authors: Randy L. Parrish, Greg C. Gibson, Michael P. Epstein, Jingjing Yang
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:HGG Advances
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S266624772100049X