Antihypertensive and Antioxidant Activity of Herbal Medicine (Jamu) B on Rats Induced by 10% Fructose
Prolonged fructose intake can activate the renin-angiotensin-aldosterone system and enhance oxidative stress conditions, causing hypertension and hyperuricemia. This study aimed to determine the antihypertensive and antioxidant activity of Jamu B on the activity of superoxide dismutase (SOD), glutat...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Universitas Indonesia
2022-04-01
|
| Series: | Pharmaceutical Sciences and Research |
| Subjects: | |
| Online Access: | https://scholarhub.ui.ac.id/psr/vol9/iss1/6/ |
| _version_ | 1811210548359987200 |
|---|---|
| author | Aprilita Rina Yanti Eff Reza Ayu Pertiwi Hermanus Ehe Hurit Sri Teguh Rahayu Yonatan Eden |
| author_facet | Aprilita Rina Yanti Eff Reza Ayu Pertiwi Hermanus Ehe Hurit Sri Teguh Rahayu Yonatan Eden |
| author_sort | Aprilita Rina Yanti Eff |
| collection | DOAJ |
| description | Prolonged fructose intake can activate the renin-angiotensin-aldosterone system and enhance oxidative stress conditions, causing hypertension and hyperuricemia. This study aimed to determine the antihypertensive and antioxidant activity of Jamu B on the activity of superoxide dismutase (SOD), glutathione (GSH), and malondialdehyde (MDA) in the kidneys of Sprague Dawley rats induced by 10% fructose. Thirty rats were divided into six groups. Groups B1-B3 were Jamu groups at a dose of 0.12 g/kg BW (B1), 0.24 g/kg BW (B2), and 0.36 g/kg BW (B3); group C (positive control) was given captopril 0.1 g/kg BW, group D (negative control) was given only 10% fructose, and group E (normal control) was healthy rats. The 10% fructose was induced for eight weeks and the treatment was given at the week 9th and 10th. Jamu B reduced systolic and diastolic blood pressure at all doses, but not significantly different from the normal control group (p>0.05). The SOD activity in groups B1, B2, B3, and C was significantly different from the negative control group (pJamu B at dose of 0.12 g/kg BW; 0.24 g/kg BW; and 0.36 g/kg BW have antihypertensive and antioxidant activity in the kidneys of rats induced by 10% fructose. Nevertheless, Jamu B at a dose of 0.36 g/kg BW was the most effective as an antihypertensive and antioxidant. |
| first_indexed | 2024-04-12T04:56:30Z |
| format | Article |
| id | doaj.art-09924533626648ddb5d98783a56d4a83 |
| institution | Directory Open Access Journal |
| issn | 2407-2354 2477-0612 |
| language | English |
| last_indexed | 2024-04-12T04:56:30Z |
| publishDate | 2022-04-01 |
| publisher | Universitas Indonesia |
| record_format | Article |
| series | Pharmaceutical Sciences and Research |
| spelling | doaj.art-09924533626648ddb5d98783a56d4a832022-12-22T03:47:05ZengUniversitas IndonesiaPharmaceutical Sciences and Research2407-23542477-06122022-04-01914250https://doi.org/10.7454/psr.v9i1.1252Antihypertensive and Antioxidant Activity of Herbal Medicine (Jamu) B on Rats Induced by 10% FructoseAprilita Rina Yanti Eff0Reza Ayu Pertiwi1Hermanus Ehe Hurit2Sri Teguh Rahayu3Yonatan Eden4Department of Pharmacy, Faculty of Health Sciences, Universitas Esa Unggul, Jakarta, IndonesiaDepartment of Pharmacy, Faculty of Health Sciences, Universitas Esa Unggul, Jakarta, IndonesiaDepartment of Pharmacy, Faculty of Health Sciences, Universitas Esa Unggul, Jakarta, IndonesiaDepartment of Pharmacy, Faculty of Health Sciences, Universitas Esa Unggul, Jakarta, IndonesiaDepartment of Pharmacy, Faculty of Health Sciences, Universitas Esa Unggul, Jakarta, IndonesiaProlonged fructose intake can activate the renin-angiotensin-aldosterone system and enhance oxidative stress conditions, causing hypertension and hyperuricemia. This study aimed to determine the antihypertensive and antioxidant activity of Jamu B on the activity of superoxide dismutase (SOD), glutathione (GSH), and malondialdehyde (MDA) in the kidneys of Sprague Dawley rats induced by 10% fructose. Thirty rats were divided into six groups. Groups B1-B3 were Jamu groups at a dose of 0.12 g/kg BW (B1), 0.24 g/kg BW (B2), and 0.36 g/kg BW (B3); group C (positive control) was given captopril 0.1 g/kg BW, group D (negative control) was given only 10% fructose, and group E (normal control) was healthy rats. The 10% fructose was induced for eight weeks and the treatment was given at the week 9th and 10th. Jamu B reduced systolic and diastolic blood pressure at all doses, but not significantly different from the normal control group (p>0.05). The SOD activity in groups B1, B2, B3, and C was significantly different from the negative control group (pJamu B at dose of 0.12 g/kg BW; 0.24 g/kg BW; and 0.36 g/kg BW have antihypertensive and antioxidant activity in the kidneys of rats induced by 10% fructose. Nevertheless, Jamu B at a dose of 0.36 g/kg BW was the most effective as an antihypertensive and antioxidant.https://scholarhub.ui.ac.id/psr/vol9/iss1/6/fructosejamukidneyglutathionemalondialdehydesuperoxide dismutase |
| spellingShingle | Aprilita Rina Yanti Eff Reza Ayu Pertiwi Hermanus Ehe Hurit Sri Teguh Rahayu Yonatan Eden Antihypertensive and Antioxidant Activity of Herbal Medicine (Jamu) B on Rats Induced by 10% Fructose Pharmaceutical Sciences and Research fructose jamu kidney glutathione malondialdehyde superoxide dismutase |
| title | Antihypertensive and Antioxidant Activity of Herbal Medicine (Jamu) B on Rats Induced by 10% Fructose |
| title_full | Antihypertensive and Antioxidant Activity of Herbal Medicine (Jamu) B on Rats Induced by 10% Fructose |
| title_fullStr | Antihypertensive and Antioxidant Activity of Herbal Medicine (Jamu) B on Rats Induced by 10% Fructose |
| title_full_unstemmed | Antihypertensive and Antioxidant Activity of Herbal Medicine (Jamu) B on Rats Induced by 10% Fructose |
| title_short | Antihypertensive and Antioxidant Activity of Herbal Medicine (Jamu) B on Rats Induced by 10% Fructose |
| title_sort | antihypertensive and antioxidant activity of herbal medicine jamu b on rats induced by 10 fructose |
| topic | fructose jamu kidney glutathione malondialdehyde superoxide dismutase |
| url | https://scholarhub.ui.ac.id/psr/vol9/iss1/6/ |
| work_keys_str_mv | AT aprilitarinayantieff antihypertensiveandantioxidantactivityofherbalmedicinejamubonratsinducedby10fructose AT rezaayupertiwi antihypertensiveandantioxidantactivityofherbalmedicinejamubonratsinducedby10fructose AT hermanusehehurit antihypertensiveandantioxidantactivityofherbalmedicinejamubonratsinducedby10fructose AT sriteguhrahayu antihypertensiveandantioxidantactivityofherbalmedicinejamubonratsinducedby10fructose AT yonataneden antihypertensiveandantioxidantactivityofherbalmedicinejamubonratsinducedby10fructose |