Nicotinamide nucleotide transhydrogenase (NNT) deficiency dysregulates mitochondrial retrograde signaling and impedes proliferation

Nicotinamide nucleotide transhydrogenase (NNT) deficiency dysregulates mitochondrial retrograde signaling and impedes proliferation

To study the physiological roles of NADH and NADPH homeostasis in cancer, we studied the effect of NNT knockdown on physiology of SK-Hep1 cells. NNT knockdown cells show limited abilities to maintain NAD+ and NADPH levels and have reduced proliferation and tumorigenicity. There is an increased depen...

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Bibliographic Details
Main Authors: Hung-Yao Ho, Yu-Ting Lin, Gigin Lin, Pei-Ru Wu, Mei-Ling Cheng
Format: Article
Language:English
Published: Elsevier 2017-08-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231717302781

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