OSTEOPOROSIS IS ASSOCIATED WITH A LOWER PREVALENCE OF BODY MASS INDEX-DEFINED OBESITY IN RHEUMATOID ARTHRITIS
Objective. The objective of this initial phase of the study is to retrospectively screen rheumatoid arthritis (RA) phenotype characteristics associated with osteoporosis. Methods. The study included all RA patients who randomly came to the university rheumatology department between January and Jul...
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| Format: | Article |
| Language: | English |
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Amaltea Medical Publishing House
2018-09-01
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| Series: | Romanian Journal of Rheumatology |
| Subjects: | |
| Online Access: | https://revistemedicale.amaltea.ro/Romanian_Journal_of_RHEUMATOLOGY/Revista_Romana_de_REUMATOLOGIE-2018-Nr.3/RJR_2018_3_Art-03.pdf |
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| author | Catalina Raluca Nuta Claudiu C. Popescu Denisa Predeteanu Ruxandra Ionescu |
| author_facet | Catalina Raluca Nuta Claudiu C. Popescu Denisa Predeteanu Ruxandra Ionescu |
| author_sort | Catalina Raluca Nuta |
| collection | DOAJ |
| description | Objective. The objective of this initial phase of the study is to retrospectively screen rheumatoid arthritis (RA)
phenotype characteristics associated with osteoporosis.
Methods. The study included all RA patients who randomly came to the university rheumatology department between January and July 2018. Demographic data, anthropometric data, RA-specific variables, osteoporosis data and comorbidities were collected retrospectively and cross-sectionally from the first (and most frequently the
only) observation sheet of each patient within the study timeframe. Correlations and comparison were analyzed
using appropriate non-parametric tests, all of the reported being significant (p<0.05).
Results. The sample included 149 RA patients (60.8 years mean age; 81.2% women), 40 (26.8%) of which had osteoporosis and 31 (20.8%) were obese. Compared to RA patients without osteoporosis, RA patients with osteoporosis were significantly older (56.0 respectively 71.0 years) and had: lower body mass index (BMI; 23.8 kg/m2 respectively 29.6 kg/m2
), longer disease duration (11.0 respectively 17.0 years), higher prevalence of rural dwelling (prevalence ratio – PR=2.46), smoking (PR=3.71), inflammation (PR=1.35), anti-citrullinated protein antibody
positivity (PR=1.51), glucocorticoids (PR=1.85) and carotid artery disease (PR=3.01), but a lower prevalence of
obesity (PR=3.43). Lumbar bone mineral density was significantly correlated with BMI (rho=0.294) and with rheumatoid factor titers (rho=0.311), controlling for age, gender and disease duration.
Conclusions. BMI-defined obesity seems to be associated with a lower prevalence of osteoporosis among RA patients, while disease severity (treatment with glucocorticoids, inflammation and ACPA positivity) is associated with a higher prevalence of osteoporosis. Gain of adipose tissue and loss of bone tissue seem to be antagonistic and parallel body composition alterations in RA. |
| first_indexed | 2024-12-13T20:40:52Z |
| format | Article |
| id | doaj.art-099580d4147f43749c05e7dde50e2dc1 |
| institution | Directory Open Access Journal |
| issn | 1843-0791 2069-6086 |
| language | English |
| last_indexed | 2024-12-13T20:40:52Z |
| publishDate | 2018-09-01 |
| publisher | Amaltea Medical Publishing House |
| record_format | Article |
| series | Romanian Journal of Rheumatology |
| spelling | doaj.art-099580d4147f43749c05e7dde50e2dc12022-12-21T23:32:09ZengAmaltea Medical Publishing HouseRomanian Journal of Rheumatology1843-07912069-60862018-09-0127311412110.37897/RJR.2018.3.3OSTEOPOROSIS IS ASSOCIATED WITH A LOWER PREVALENCE OF BODY MASS INDEX-DEFINED OBESITY IN RHEUMATOID ARTHRITISCatalina Raluca Nuta0Claudiu C. Popescu1Denisa Predeteanu2Ruxandra Ionescu3Ana Aslan National Institute of Gerontology and Geriatrics, Bucharest; Carol Davila University of Medicine and Pharmacy, BucharestCarol Davila University of Medicine and Pharmacy, Bucharest; Dr. Ion Stoia Clinical Centre for Rheumatic Diseases, BucharestCarol Davila University of Medicine and Pharmacy, Bucharest; Sf. Maria Clinical Hospital, BucharestCarol Davila University of Medicine and Pharmacy, Bucharest; Sf. Maria Clinical Hospital, BucharestObjective. The objective of this initial phase of the study is to retrospectively screen rheumatoid arthritis (RA) phenotype characteristics associated with osteoporosis. Methods. The study included all RA patients who randomly came to the university rheumatology department between January and July 2018. Demographic data, anthropometric data, RA-specific variables, osteoporosis data and comorbidities were collected retrospectively and cross-sectionally from the first (and most frequently the only) observation sheet of each patient within the study timeframe. Correlations and comparison were analyzed using appropriate non-parametric tests, all of the reported being significant (p<0.05). Results. The sample included 149 RA patients (60.8 years mean age; 81.2% women), 40 (26.8%) of which had osteoporosis and 31 (20.8%) were obese. Compared to RA patients without osteoporosis, RA patients with osteoporosis were significantly older (56.0 respectively 71.0 years) and had: lower body mass index (BMI; 23.8 kg/m2 respectively 29.6 kg/m2 ), longer disease duration (11.0 respectively 17.0 years), higher prevalence of rural dwelling (prevalence ratio – PR=2.46), smoking (PR=3.71), inflammation (PR=1.35), anti-citrullinated protein antibody positivity (PR=1.51), glucocorticoids (PR=1.85) and carotid artery disease (PR=3.01), but a lower prevalence of obesity (PR=3.43). Lumbar bone mineral density was significantly correlated with BMI (rho=0.294) and with rheumatoid factor titers (rho=0.311), controlling for age, gender and disease duration. Conclusions. BMI-defined obesity seems to be associated with a lower prevalence of osteoporosis among RA patients, while disease severity (treatment with glucocorticoids, inflammation and ACPA positivity) is associated with a higher prevalence of osteoporosis. Gain of adipose tissue and loss of bone tissue seem to be antagonistic and parallel body composition alterations in RA.https://revistemedicale.amaltea.ro/Romanian_Journal_of_RHEUMATOLOGY/Revista_Romana_de_REUMATOLOGIE-2018-Nr.3/RJR_2018_3_Art-03.pdfrheumatoid arthritisosteoporosisobesity |
| spellingShingle | Catalina Raluca Nuta Claudiu C. Popescu Denisa Predeteanu Ruxandra Ionescu OSTEOPOROSIS IS ASSOCIATED WITH A LOWER PREVALENCE OF BODY MASS INDEX-DEFINED OBESITY IN RHEUMATOID ARTHRITIS Romanian Journal of Rheumatology rheumatoid arthritis osteoporosis obesity |
| title | OSTEOPOROSIS IS ASSOCIATED WITH A LOWER PREVALENCE OF BODY MASS INDEX-DEFINED OBESITY IN RHEUMATOID ARTHRITIS |
| title_full | OSTEOPOROSIS IS ASSOCIATED WITH A LOWER PREVALENCE OF BODY MASS INDEX-DEFINED OBESITY IN RHEUMATOID ARTHRITIS |
| title_fullStr | OSTEOPOROSIS IS ASSOCIATED WITH A LOWER PREVALENCE OF BODY MASS INDEX-DEFINED OBESITY IN RHEUMATOID ARTHRITIS |
| title_full_unstemmed | OSTEOPOROSIS IS ASSOCIATED WITH A LOWER PREVALENCE OF BODY MASS INDEX-DEFINED OBESITY IN RHEUMATOID ARTHRITIS |
| title_short | OSTEOPOROSIS IS ASSOCIATED WITH A LOWER PREVALENCE OF BODY MASS INDEX-DEFINED OBESITY IN RHEUMATOID ARTHRITIS |
| title_sort | osteoporosis is associated with a lower prevalence of body mass index defined obesity in rheumatoid arthritis |
| topic | rheumatoid arthritis osteoporosis obesity |
| url | https://revistemedicale.amaltea.ro/Romanian_Journal_of_RHEUMATOLOGY/Revista_Romana_de_REUMATOLOGIE-2018-Nr.3/RJR_2018_3_Art-03.pdf |
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