Cardiac Manifestations in Children with SARS-COV-2 Infection: 1-Year Pediatric Multicenter Experience
Since the spread of COVID-19, pediatric patients were initially considered less affected by SARS-COV-2, but current literature reported subsets of children with multisystem inflammatory syndrome (MIS-C). This study aims to describe the cardiac manifestation of SARS-COV-2 infection in a large cohort...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/8/8/717 |
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| author | Nicoletta Cantarutti Virginia Battista Rachele Adorisio Marianna Cicenia Claudia Campanello Elisa Listo Andrea Campana Gianluca Trocchio Fabrizio Drago |
| author_facet | Nicoletta Cantarutti Virginia Battista Rachele Adorisio Marianna Cicenia Claudia Campanello Elisa Listo Andrea Campana Gianluca Trocchio Fabrizio Drago |
| author_sort | Nicoletta Cantarutti |
| collection | DOAJ |
| description | Since the spread of COVID-19, pediatric patients were initially considered less affected by SARS-COV-2, but current literature reported subsets of children with multisystem inflammatory syndrome (MIS-C). This study aims to describe the cardiac manifestation of SARS-COV-2 infection in a large cohort of children admitted to two Italian pediatric referral centers. Between March 2020 and March 2021, we performed a cardiac evaluation in 294 children (mean age 9 ± 5.9 years, male 60%) with active or previous SARS-COV-2 infection. Twenty-six showed ECG abnormalities: 63 repolarization anomalies, 13 Long QTc, five premature ventricular beats, two non-sustained ventricular tachycardia, and one atrial fibrillation. In total, 146 patients underwent cardiac biomarkers: NT-proBNP was elevated in 57, troponin in 34. An echocardiogram was performed in 98, showing 54 cardiac anomalies: 27 left-ventricular dysfunction, 42 pericarditis, 16 coronaritis. MIS-C was documented in 46 patients (mean age 9 ± 4.8 years, male 61%) with cardiac manifestations in 97.8%: 27 ventricular dysfunctions, 32 pericarditis, 15 coronaritis, 3 arrhythmias. All patients recovered, and during follow-up, no cardiac anomalies were recorded. Our experience showed that cardiac involvement is not rare in children with SARS-COV-2, and occurred in almost all patients with MIS-C. However, patients’ recovery is satisfactory and no additional events were reported during FU. |
| first_indexed | 2024-03-10T08:54:11Z |
| format | Article |
| id | doaj.art-099595ed53db46cda3e0cd4baf3e298e |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-10T08:54:11Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-099595ed53db46cda3e0cd4baf3e298e2023-11-22T07:14:53ZengMDPI AGChildren2227-90672021-08-018871710.3390/children8080717Cardiac Manifestations in Children with SARS-COV-2 Infection: 1-Year Pediatric Multicenter ExperienceNicoletta Cantarutti0Virginia Battista1Rachele Adorisio2Marianna Cicenia3Claudia Campanello4Elisa Listo5Andrea Campana6Gianluca Trocchio7Fabrizio Drago8Cardiology and Arrhythmias Complex Unit, Department of Pediatric Cardiology and Cardiac Surgery, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, ItalyCardiology and Arrhythmias Complex Unit, Department of Pediatric Cardiology and Cardiac Surgery, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, ItalyCardiology and Arrhythmias Complex Unit, Department of Pediatric Cardiology and Cardiac Surgery, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, ItalyCardiology and Arrhythmias Complex Unit, Department of Pediatric Cardiology and Cardiac Surgery, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, ItalyDepartment of Neuroscience, Rehabilitation, Ophtalmology, Genetics, Maternal and Child Health (DINOGMI), Istituto Giannina Gaslini, University of Genoa, IRCCS, 16100 Genoa, ItalyDepartment of Health Sciences DiSSal, University of Genoa, Ospedale-Policlinico San Martino, IRCCS, 16100 Genoa, ItalyAcademic Department of Pediatrics, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, ItalyCardiology Unit, Istituto Giannina Gaslini, 16100 Genoa, ItalyCardiology and Arrhythmias Complex Unit, Department of Pediatric Cardiology and Cardiac Surgery, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, ItalySince the spread of COVID-19, pediatric patients were initially considered less affected by SARS-COV-2, but current literature reported subsets of children with multisystem inflammatory syndrome (MIS-C). This study aims to describe the cardiac manifestation of SARS-COV-2 infection in a large cohort of children admitted to two Italian pediatric referral centers. Between March 2020 and March 2021, we performed a cardiac evaluation in 294 children (mean age 9 ± 5.9 years, male 60%) with active or previous SARS-COV-2 infection. Twenty-six showed ECG abnormalities: 63 repolarization anomalies, 13 Long QTc, five premature ventricular beats, two non-sustained ventricular tachycardia, and one atrial fibrillation. In total, 146 patients underwent cardiac biomarkers: NT-proBNP was elevated in 57, troponin in 34. An echocardiogram was performed in 98, showing 54 cardiac anomalies: 27 left-ventricular dysfunction, 42 pericarditis, 16 coronaritis. MIS-C was documented in 46 patients (mean age 9 ± 4.8 years, male 61%) with cardiac manifestations in 97.8%: 27 ventricular dysfunctions, 32 pericarditis, 15 coronaritis, 3 arrhythmias. All patients recovered, and during follow-up, no cardiac anomalies were recorded. Our experience showed that cardiac involvement is not rare in children with SARS-COV-2, and occurred in almost all patients with MIS-C. However, patients’ recovery is satisfactory and no additional events were reported during FU.https://www.mdpi.com/2227-9067/8/8/717myocarditiscardiac involvementchildrenMIS-CSARS-COV-2COVID-19 |
| spellingShingle | Nicoletta Cantarutti Virginia Battista Rachele Adorisio Marianna Cicenia Claudia Campanello Elisa Listo Andrea Campana Gianluca Trocchio Fabrizio Drago Cardiac Manifestations in Children with SARS-COV-2 Infection: 1-Year Pediatric Multicenter Experience Children myocarditis cardiac involvement children MIS-C SARS-COV-2 COVID-19 |
| title | Cardiac Manifestations in Children with SARS-COV-2 Infection: 1-Year Pediatric Multicenter Experience |
| title_full | Cardiac Manifestations in Children with SARS-COV-2 Infection: 1-Year Pediatric Multicenter Experience |
| title_fullStr | Cardiac Manifestations in Children with SARS-COV-2 Infection: 1-Year Pediatric Multicenter Experience |
| title_full_unstemmed | Cardiac Manifestations in Children with SARS-COV-2 Infection: 1-Year Pediatric Multicenter Experience |
| title_short | Cardiac Manifestations in Children with SARS-COV-2 Infection: 1-Year Pediatric Multicenter Experience |
| title_sort | cardiac manifestations in children with sars cov 2 infection 1 year pediatric multicenter experience |
| topic | myocarditis cardiac involvement children MIS-C SARS-COV-2 COVID-19 |
| url | https://www.mdpi.com/2227-9067/8/8/717 |
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