Late-onset doxorubicin-induced congestive heart failure in an elderly cancer survivor: A case report
BackgroundRecently, the survival rate of patients with cancer has improved annually due to advancements in cancer diagnosis and treatment technologies. Meanwhile, late-onset complications associated with cancer treatment significantly affect survival and quality of life. However, different from pedi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1124276/full |
| _version_ | 1797839985692377088 |
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| author | Hirotaka Suto Hirotaka Suto Makiko Suto Yumiko Inui Atsuo Okamura |
| author_facet | Hirotaka Suto Hirotaka Suto Makiko Suto Yumiko Inui Atsuo Okamura |
| author_sort | Hirotaka Suto |
| collection | DOAJ |
| description | BackgroundRecently, the survival rate of patients with cancer has improved annually due to advancements in cancer diagnosis and treatment technologies. Meanwhile, late-onset complications associated with cancer treatment significantly affect survival and quality of life. However, different from pediatric cancer survivors, there is no unified view on the follow-up of late complications in elderly cancer survivors. We reported a case of congestive heart failure as a late-onset complication of doxorubicin (DXR) in an elderly cancer survivor.Case reportThe patient is an 80-year-old woman with hypertension and chronic renal failure. She received six cycles of chemotherapy for Hodgkin's lymphoma that started in January 201X-2. The total dose of DXR was 300 mg/m2, and a transthoracic echocardiogram (TTE) performed in October 201X-2, showed good left ventricular wall motion (LVWM). In April 201X, she suddenly developed dyspnea. Upon arrival at the hospital, a physical examination revealed orthopnea, tachycardia, and leg edema. A chest radiograph showed cardiac enlargement and pleural effusion. A TTE showed diffusely reduced LVWM and a left ventricular ejection fraction in the 20% range. After close examination, the patient was diagnosed with congestive heart failure due to late-onset DXR-induced cardiomyopathy.ConclusionLate-onset DXR-induced cardiotoxicity is considered high-risk from 250 mg/m2 or higher. Elderly cancer survivors are at higher risk of cardiotoxicity than non-elderly cancer survivors and may require closer follow-up. |
| first_indexed | 2024-04-09T16:07:00Z |
| format | Article |
| id | doaj.art-0995ee909df848ef906b33db4548c27a |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-09T16:07:00Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-0995ee909df848ef906b33db4548c27a2023-04-25T04:38:08ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-04-011010.3389/fcvm.2023.11242761124276Late-onset doxorubicin-induced congestive heart failure in an elderly cancer survivor: A case reportHirotaka Suto0Hirotaka Suto1Makiko Suto2Yumiko Inui3Atsuo Okamura4Department of Medical Oncology, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, JapanDepartment of Medical Oncology/Hematology, Kakogawa Central City Hospital, Hyogo, JapanDepartment of Cardiovascular Medicine, Takarazuka City Hospital, Hyogo, JapanDepartment of Medical Oncology/Hematology, Kakogawa Central City Hospital, Hyogo, JapanDepartment of Medical Oncology/Hematology, Kakogawa Central City Hospital, Hyogo, JapanBackgroundRecently, the survival rate of patients with cancer has improved annually due to advancements in cancer diagnosis and treatment technologies. Meanwhile, late-onset complications associated with cancer treatment significantly affect survival and quality of life. However, different from pediatric cancer survivors, there is no unified view on the follow-up of late complications in elderly cancer survivors. We reported a case of congestive heart failure as a late-onset complication of doxorubicin (DXR) in an elderly cancer survivor.Case reportThe patient is an 80-year-old woman with hypertension and chronic renal failure. She received six cycles of chemotherapy for Hodgkin's lymphoma that started in January 201X-2. The total dose of DXR was 300 mg/m2, and a transthoracic echocardiogram (TTE) performed in October 201X-2, showed good left ventricular wall motion (LVWM). In April 201X, she suddenly developed dyspnea. Upon arrival at the hospital, a physical examination revealed orthopnea, tachycardia, and leg edema. A chest radiograph showed cardiac enlargement and pleural effusion. A TTE showed diffusely reduced LVWM and a left ventricular ejection fraction in the 20% range. After close examination, the patient was diagnosed with congestive heart failure due to late-onset DXR-induced cardiomyopathy.ConclusionLate-onset DXR-induced cardiotoxicity is considered high-risk from 250 mg/m2 or higher. Elderly cancer survivors are at higher risk of cardiotoxicity than non-elderly cancer survivors and may require closer follow-up.https://www.frontiersin.org/articles/10.3389/fcvm.2023.1124276/fulldoxorubicincardiotoxicityonco-cardiologycancer survivorelderlytroponin I |
| spellingShingle | Hirotaka Suto Hirotaka Suto Makiko Suto Yumiko Inui Atsuo Okamura Late-onset doxorubicin-induced congestive heart failure in an elderly cancer survivor: A case report Frontiers in Cardiovascular Medicine doxorubicin cardiotoxicity onco-cardiology cancer survivor elderly troponin I |
| title | Late-onset doxorubicin-induced congestive heart failure in an elderly cancer survivor: A case report |
| title_full | Late-onset doxorubicin-induced congestive heart failure in an elderly cancer survivor: A case report |
| title_fullStr | Late-onset doxorubicin-induced congestive heart failure in an elderly cancer survivor: A case report |
| title_full_unstemmed | Late-onset doxorubicin-induced congestive heart failure in an elderly cancer survivor: A case report |
| title_short | Late-onset doxorubicin-induced congestive heart failure in an elderly cancer survivor: A case report |
| title_sort | late onset doxorubicin induced congestive heart failure in an elderly cancer survivor a case report |
| topic | doxorubicin cardiotoxicity onco-cardiology cancer survivor elderly troponin I |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1124276/full |
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