Incomplete vesicular docking limits synaptic strength under high release probability conditions
Central mammalian synapses release synaptic vesicles in dedicated structures called docking/release sites. It has been assumed that when voltage-dependent calcium entry is sufficiently large, synaptic output attains a maximum value of one synaptic vesicle per action potential and per site. Here we u...
Main Authors: | Gerardo Malagon, Takafumi Miki, Van Tran, Laura C Gomez, Alain Marty |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2020-03-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/52137 |
Similar Items
-
Proteolytic maturation of α2δ controls the probability of synaptic vesicular release
by: Laurent Ferron, et al.
Published: (2018-06-01) -
Upregulation of transmitter release probability improves a conversion of synaptic analogue signals into neuronal digital spikes
by: Yu Jiandong, et al.
Published: (2012-08-01) -
Calcium dependence of neurotransmitter release at a high fidelity synapse
by: Abdelmoneim Eshra, et al.
Published: (2021-10-01) -
Human pyramidal to interneuron synapses are mediated by multi-vesicular release and multiple docked vesicles
by: Gábor Molnár, et al.
Published: (2016-08-01) -
Astrocytes control hippocampal synaptic plasticity through the vesicular-dependent release of D-serine
by: Daniela Sofia Abreu, et al.
Published: (2023-12-01)