Group B Streptococcal Hemolytic Pigment Impairs Platelet Function in a Two-Step Process
Group B streptococci (GBS) cause a range of invasive maternal–fetal diseases during pregnancy and post-partum. However, invasive infections in non-pregnant adults are constantly increasing. These include sepsis and streptococcal toxic shock syndrome, which are often complicated by systemic coagulati...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/10/1637 |
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| author | Kristin Jahn Patience Shumba Phoenicia Quach Mathias Müsken Jan Wesche Andreas Greinacher Lakshmi Rajagopal Sven Hammerschmidt Nikolai Siemens |
| author_facet | Kristin Jahn Patience Shumba Phoenicia Quach Mathias Müsken Jan Wesche Andreas Greinacher Lakshmi Rajagopal Sven Hammerschmidt Nikolai Siemens |
| author_sort | Kristin Jahn |
| collection | DOAJ |
| description | Group B streptococci (GBS) cause a range of invasive maternal–fetal diseases during pregnancy and post-partum. However, invasive infections in non-pregnant adults are constantly increasing. These include sepsis and streptococcal toxic shock syndrome, which are often complicated by systemic coagulation and thrombocytopenia. GBS express a hyper-hemolytic ornithine rhamnolipid pigment toxin with cytolytic and coagulatory activity. Here, we investigated the effects of GBS pigment on human platelets. Infections of platelets with pigmented GBS resulted initially in platelet activation, followed by necrotic cell death. Thus, this study shows that GBS pigment kills human platelets. |
| first_indexed | 2024-03-10T03:10:15Z |
| format | Article |
| id | doaj.art-09973cb86fc9423784cd5f9ef62f36b4 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T03:10:15Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-09973cb86fc9423784cd5f9ef62f36b42023-11-23T10:27:30ZengMDPI AGCells2073-44092022-05-011110163710.3390/cells11101637Group B Streptococcal Hemolytic Pigment Impairs Platelet Function in a Two-Step ProcessKristin Jahn0Patience Shumba1Phoenicia Quach2Mathias Müsken3Jan Wesche4Andreas Greinacher5Lakshmi Rajagopal6Sven Hammerschmidt7Nikolai Siemens8Center for Functional Genomics of Microbes, Department of Molecular Genetics and Infection Biology, Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, 17489 Greifswald, GermanyCenter for Functional Genomics of Microbes, Department of Molecular Genetics and Infection Biology, Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, 17489 Greifswald, GermanyDepartment of Global Health, University of Washington, Seattle, WA 98105, USACentral Facility for Microscopy, Helmholtz Centre for Infection Research, 38124 Braunschweig, GermanyDepartment of Transfusion Medicine, Institute of Immunology and Transfusion Medicine, University Medicine Greifswald, 17475 Greifswald, GermanyDepartment of Transfusion Medicine, Institute of Immunology and Transfusion Medicine, University Medicine Greifswald, 17475 Greifswald, GermanyDepartment of Global Health, University of Washington, Seattle, WA 98105, USACenter for Functional Genomics of Microbes, Department of Molecular Genetics and Infection Biology, Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, 17489 Greifswald, GermanyCenter for Functional Genomics of Microbes, Department of Molecular Genetics and Infection Biology, Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, 17489 Greifswald, GermanyGroup B streptococci (GBS) cause a range of invasive maternal–fetal diseases during pregnancy and post-partum. However, invasive infections in non-pregnant adults are constantly increasing. These include sepsis and streptococcal toxic shock syndrome, which are often complicated by systemic coagulation and thrombocytopenia. GBS express a hyper-hemolytic ornithine rhamnolipid pigment toxin with cytolytic and coagulatory activity. Here, we investigated the effects of GBS pigment on human platelets. Infections of platelets with pigmented GBS resulted initially in platelet activation, followed by necrotic cell death. Thus, this study shows that GBS pigment kills human platelets.https://www.mdpi.com/2073-4409/11/10/1637<i>Streptococcus agalactiae</i>group B streptococcuspigmentplatelets |
| spellingShingle | Kristin Jahn Patience Shumba Phoenicia Quach Mathias Müsken Jan Wesche Andreas Greinacher Lakshmi Rajagopal Sven Hammerschmidt Nikolai Siemens Group B Streptococcal Hemolytic Pigment Impairs Platelet Function in a Two-Step Process Cells <i>Streptococcus agalactiae</i> group B streptococcus pigment platelets |
| title | Group B Streptococcal Hemolytic Pigment Impairs Platelet Function in a Two-Step Process |
| title_full | Group B Streptococcal Hemolytic Pigment Impairs Platelet Function in a Two-Step Process |
| title_fullStr | Group B Streptococcal Hemolytic Pigment Impairs Platelet Function in a Two-Step Process |
| title_full_unstemmed | Group B Streptococcal Hemolytic Pigment Impairs Platelet Function in a Two-Step Process |
| title_short | Group B Streptococcal Hemolytic Pigment Impairs Platelet Function in a Two-Step Process |
| title_sort | group b streptococcal hemolytic pigment impairs platelet function in a two step process |
| topic | <i>Streptococcus agalactiae</i> group B streptococcus pigment platelets |
| url | https://www.mdpi.com/2073-4409/11/10/1637 |
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