Electrophysiological indices of pain expectation abnormalities in fibromyalgia patients
Fibromyalgia is a chronic pain syndrome characterized by dysfunctional processing of nociceptive stimulation. Neuroimaging studies have pointed out that pain-related network functioning seems to be altered in these patients. It is thought that this clinical symptomatology may be maintained or even s...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnhum.2022.943976/full |
| _version_ | 1828385355608358912 |
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| author | Paloma Barjola Irene Peláez David Ferrera José Luis González-Gutiérrez Lilian Velasco Cecilia Peñacoba-Puente Almudena López-López Roberto Fernandes-Magalhaes Francisco Mercado |
| author_facet | Paloma Barjola Irene Peláez David Ferrera José Luis González-Gutiérrez Lilian Velasco Cecilia Peñacoba-Puente Almudena López-López Roberto Fernandes-Magalhaes Francisco Mercado |
| author_sort | Paloma Barjola |
| collection | DOAJ |
| description | Fibromyalgia is a chronic pain syndrome characterized by dysfunctional processing of nociceptive stimulation. Neuroimaging studies have pointed out that pain-related network functioning seems to be altered in these patients. It is thought that this clinical symptomatology may be maintained or even strengthened because of an enhanced expectancy for painful stimuli or its forthcoming appearance. However, neural electrophysiological correlates associated with such attentional mechanisms have been scarcely explored. In the current study, expectancy processes of upcoming laser stimulation (painful and non-painful) and its further processing were explored by event-related potentials (ERPs). Nineteen fibromyalgia patients and twenty healthy control volunteers took part in the experiment. Behavioral measures (reaction times and subjective pain perception) were also collected. We manipulated the pain/no pain expectancy through an S1–S2 paradigm (cue-target). S1 (image: triangle or square) predicted the S2 appearance (laser stimulation: warmth or pinprick sensation). Laser stimuli were delivered using a CO2 laser device. Temporal and spatial principal component analyses were employed to define and quantify the ERP component reliability. Statistical analyses revealed the existence of an abnormal pattern of pain expectancy in patients with fibromyalgia. Specifically, our results showed attenuated amplitudes at posterior lCNV component in anticipation of painful stimulation that was not found in healthy participants. In contrast, although larger P2 amplitudes to painful compared to innocuous events were shown, patients did not show any amplitude change in this laser-evoked response as a function of pain predictive cues (as occurred in the healthy control group). Additionally, analyses of the subjective perception of pain and reaction time indicated that laser stimuli preceded by pain cues were rated as more painful than those signaling non-pain expectancy and were associated with faster responses. Differences between groups were not found. The present findings suggest the presence of dysfunction in pain expectation mechanisms in fibromyalgia that eventually may make it difficult for patients to correctly interpret signs that prevent pain symptoms. Furthermore, the abnormal pattern in pain expectancy displayed by fibromyalgia patients could result in ineffective pain coping strategies. Understanding the neural correlates of pain processing and its modulatory factors is crucial to identify treatments for chronic pain syndromes. |
| first_indexed | 2024-12-10T05:19:09Z |
| format | Article |
| id | doaj.art-099917d955ae4624873c18a701b2ed24 |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-10T05:19:09Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-099917d955ae4624873c18a701b2ed242022-12-22T02:00:51ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612022-09-011610.3389/fnhum.2022.943976943976Electrophysiological indices of pain expectation abnormalities in fibromyalgia patientsPaloma BarjolaIrene PeláezDavid FerreraJosé Luis González-GutiérrezLilian VelascoCecilia Peñacoba-PuenteAlmudena López-LópezRoberto Fernandes-MagalhaesFrancisco MercadoFibromyalgia is a chronic pain syndrome characterized by dysfunctional processing of nociceptive stimulation. Neuroimaging studies have pointed out that pain-related network functioning seems to be altered in these patients. It is thought that this clinical symptomatology may be maintained or even strengthened because of an enhanced expectancy for painful stimuli or its forthcoming appearance. However, neural electrophysiological correlates associated with such attentional mechanisms have been scarcely explored. In the current study, expectancy processes of upcoming laser stimulation (painful and non-painful) and its further processing were explored by event-related potentials (ERPs). Nineteen fibromyalgia patients and twenty healthy control volunteers took part in the experiment. Behavioral measures (reaction times and subjective pain perception) were also collected. We manipulated the pain/no pain expectancy through an S1–S2 paradigm (cue-target). S1 (image: triangle or square) predicted the S2 appearance (laser stimulation: warmth or pinprick sensation). Laser stimuli were delivered using a CO2 laser device. Temporal and spatial principal component analyses were employed to define and quantify the ERP component reliability. Statistical analyses revealed the existence of an abnormal pattern of pain expectancy in patients with fibromyalgia. Specifically, our results showed attenuated amplitudes at posterior lCNV component in anticipation of painful stimulation that was not found in healthy participants. In contrast, although larger P2 amplitudes to painful compared to innocuous events were shown, patients did not show any amplitude change in this laser-evoked response as a function of pain predictive cues (as occurred in the healthy control group). Additionally, analyses of the subjective perception of pain and reaction time indicated that laser stimuli preceded by pain cues were rated as more painful than those signaling non-pain expectancy and were associated with faster responses. Differences between groups were not found. The present findings suggest the presence of dysfunction in pain expectation mechanisms in fibromyalgia that eventually may make it difficult for patients to correctly interpret signs that prevent pain symptoms. Furthermore, the abnormal pattern in pain expectancy displayed by fibromyalgia patients could result in ineffective pain coping strategies. Understanding the neural correlates of pain processing and its modulatory factors is crucial to identify treatments for chronic pain syndromes.https://www.frontiersin.org/articles/10.3389/fnhum.2022.943976/fullpain expectationsCNVLEPsfibromyalgiapain processingP2 |
| spellingShingle | Paloma Barjola Irene Peláez David Ferrera José Luis González-Gutiérrez Lilian Velasco Cecilia Peñacoba-Puente Almudena López-López Roberto Fernandes-Magalhaes Francisco Mercado Electrophysiological indices of pain expectation abnormalities in fibromyalgia patients Frontiers in Human Neuroscience pain expectations CNV LEPs fibromyalgia pain processing P2 |
| title | Electrophysiological indices of pain expectation abnormalities in fibromyalgia patients |
| title_full | Electrophysiological indices of pain expectation abnormalities in fibromyalgia patients |
| title_fullStr | Electrophysiological indices of pain expectation abnormalities in fibromyalgia patients |
| title_full_unstemmed | Electrophysiological indices of pain expectation abnormalities in fibromyalgia patients |
| title_short | Electrophysiological indices of pain expectation abnormalities in fibromyalgia patients |
| title_sort | electrophysiological indices of pain expectation abnormalities in fibromyalgia patients |
| topic | pain expectations CNV LEPs fibromyalgia pain processing P2 |
| url | https://www.frontiersin.org/articles/10.3389/fnhum.2022.943976/full |
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