Peripheral OCT Assisted by Scleral Depression in Retinopathy of Prematurity
Purpose: To determine whether handheld widefield OCT can be used to document retinopathy of prematurity (ROP) stage while using scleral depression to improve peripheral views. Design: Prospective, observational study. Participants: Consecutive neonates admitted to the neonatal intensive care unit in...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-03-01
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| Series: | Ophthalmology Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666914521000956 |
| _version_ | 1818315334073974784 |
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| author | Brittni A. Scruggs, MD, PhD Shuibin Ni, MS Thanh-Tin P. Nguyen, MD Susan Ostmo, MS Michael F. Chiang, MD Yali Jia, PhD David Huang, MD, PhD Yifan Jian, PhD J. Peter Campbell, MD, MPH |
| author_facet | Brittni A. Scruggs, MD, PhD Shuibin Ni, MS Thanh-Tin P. Nguyen, MD Susan Ostmo, MS Michael F. Chiang, MD Yali Jia, PhD David Huang, MD, PhD Yifan Jian, PhD J. Peter Campbell, MD, MPH |
| author_sort | Brittni A. Scruggs, MD, PhD |
| collection | DOAJ |
| description | Purpose: To determine whether handheld widefield OCT can be used to document retinopathy of prematurity (ROP) stage while using scleral depression to improve peripheral views. Design: Prospective, observational study. Participants: Consecutive neonates admitted to the neonatal intensive care unit in a single academic medical center who also met criteria for ROP screening and whose parents or guardians consented for them to undergo research imaging. Methods: Scleral depression was combined with widefield OCT using an investigational 400-kHz, 55° field of view, handheld OCT during routine ROP screening from October 28, 2020, through March 3, 2021. Main Outcome Measures: Acquisition of en face and B-scan imaging of the peripheral retina to assess early vitreoretinal pathologic features objectively, including the demarcation between vascularized and anterior avascular retina, the presence of early ridge formation, and small neovascular tufts. Results: Various stages of ROP were detected using a rapid-acquisition OCT system. In 1 neonate, serial OCT imaging over a 5-week period demonstrated accumulation of neovascular tufts with progression to stage 3 ROP with extraretinal fibrovascular proliferation along the ridge. Videography of this technique is included in this report for instructional purposes. Conclusions: Serial examinations using widefield OCT and scleral depression are feasible and may improve detection and documentation of ROP disease progression. Earlier detection of ROP-related proliferation may prevent vitreoretinal traction, retinal detachment, and blindness. |
| first_indexed | 2024-12-13T09:03:53Z |
| format | Article |
| id | doaj.art-09993a1ac79942fba545e11bc6eb9c32 |
| institution | Directory Open Access Journal |
| issn | 2666-9145 |
| language | English |
| last_indexed | 2024-12-13T09:03:53Z |
| publishDate | 2022-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ophthalmology Science |
| spelling | doaj.art-09993a1ac79942fba545e11bc6eb9c322022-12-21T23:53:06ZengElsevierOphthalmology Science2666-91452022-03-0121100094Peripheral OCT Assisted by Scleral Depression in Retinopathy of PrematurityBrittni A. Scruggs, MD, PhD0Shuibin Ni, MS1Thanh-Tin P. Nguyen, MD2Susan Ostmo, MS3Michael F. Chiang, MD4Yali Jia, PhD5David Huang, MD, PhD6Yifan Jian, PhD7J. Peter Campbell, MD, MPH8Casey Eye Institute, Department of Ophthalmology, Oregon Health & Science University, Portland, OregonCasey Eye Institute, Department of Ophthalmology, Oregon Health & Science University, Portland, OregonCasey Eye Institute, Department of Ophthalmology, Oregon Health & Science University, Portland, OregonCasey Eye Institute, Department of Ophthalmology, Oregon Health & Science University, Portland, OregonNational Eye Institute, National Institutes of Health, Bethesda, MarylandCasey Eye Institute, Department of Ophthalmology, Oregon Health & Science University, Portland, OregonCasey Eye Institute, Department of Ophthalmology, Oregon Health & Science University, Portland, OregonCasey Eye Institute, Department of Ophthalmology, Oregon Health & Science University, Portland, OregonCasey Eye Institute, Department of Ophthalmology, Oregon Health & Science University, Portland, Oregon; Correspondence: J. Peter Campbell, MD, MPH, Casey Eye Institute, Department of Ophthalmology, Oregon Health & Science University, 515 SW Campus Drive, Portland, OR 97239.Purpose: To determine whether handheld widefield OCT can be used to document retinopathy of prematurity (ROP) stage while using scleral depression to improve peripheral views. Design: Prospective, observational study. Participants: Consecutive neonates admitted to the neonatal intensive care unit in a single academic medical center who also met criteria for ROP screening and whose parents or guardians consented for them to undergo research imaging. Methods: Scleral depression was combined with widefield OCT using an investigational 400-kHz, 55° field of view, handheld OCT during routine ROP screening from October 28, 2020, through March 3, 2021. Main Outcome Measures: Acquisition of en face and B-scan imaging of the peripheral retina to assess early vitreoretinal pathologic features objectively, including the demarcation between vascularized and anterior avascular retina, the presence of early ridge formation, and small neovascular tufts. Results: Various stages of ROP were detected using a rapid-acquisition OCT system. In 1 neonate, serial OCT imaging over a 5-week period demonstrated accumulation of neovascular tufts with progression to stage 3 ROP with extraretinal fibrovascular proliferation along the ridge. Videography of this technique is included in this report for instructional purposes. Conclusions: Serial examinations using widefield OCT and scleral depression are feasible and may improve detection and documentation of ROP disease progression. Earlier detection of ROP-related proliferation may prevent vitreoretinal traction, retinal detachment, and blindness.http://www.sciencedirect.com/science/article/pii/S2666914521000956OCTRetinopathy of prematurityScleral depression |
| spellingShingle | Brittni A. Scruggs, MD, PhD Shuibin Ni, MS Thanh-Tin P. Nguyen, MD Susan Ostmo, MS Michael F. Chiang, MD Yali Jia, PhD David Huang, MD, PhD Yifan Jian, PhD J. Peter Campbell, MD, MPH Peripheral OCT Assisted by Scleral Depression in Retinopathy of Prematurity Ophthalmology Science OCT Retinopathy of prematurity Scleral depression |
| title | Peripheral OCT Assisted by Scleral Depression in Retinopathy of Prematurity |
| title_full | Peripheral OCT Assisted by Scleral Depression in Retinopathy of Prematurity |
| title_fullStr | Peripheral OCT Assisted by Scleral Depression in Retinopathy of Prematurity |
| title_full_unstemmed | Peripheral OCT Assisted by Scleral Depression in Retinopathy of Prematurity |
| title_short | Peripheral OCT Assisted by Scleral Depression in Retinopathy of Prematurity |
| title_sort | peripheral oct assisted by scleral depression in retinopathy of prematurity |
| topic | OCT Retinopathy of prematurity Scleral depression |
| url | http://www.sciencedirect.com/science/article/pii/S2666914521000956 |
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