Isoalantolactone (IAL) Regulates Neuro-Inflammation and Neuronal Apoptosis to Curb Pathology of Parkinson’s Disease
Parkinson’s disease (PD) is a neurodegenerative disease in which neuronal apoptosis and associated inflammation are involved in its pathogenesis. However, there is still no specific treatment that can stop PD progression. Isoalantolactone (IAL) plays a role in many inflammation-related diseases. How...
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MDPI AG
2022-09-01
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| author | Dewei He Yanting Liu Jie Li Hefei Wang Bojian Ye Yuan He Zhe Li Xiyu Gao Shoupeng Fu Dianfeng Liu |
| author_facet | Dewei He Yanting Liu Jie Li Hefei Wang Bojian Ye Yuan He Zhe Li Xiyu Gao Shoupeng Fu Dianfeng Liu |
| author_sort | Dewei He |
| collection | DOAJ |
| description | Parkinson’s disease (PD) is a neurodegenerative disease in which neuronal apoptosis and associated inflammation are involved in its pathogenesis. However, there is still no specific treatment that can stop PD progression. Isoalantolactone (IAL) plays a role in many inflammation-related diseases. However, its effect and mechanism in PD remain unclear. In this study, results showed that IAL administration ameliorated 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced PD-related pathological impairment and decreased motor activity in mice. Results from in vitro mechanistic studies showed that IAL regulated apoptosis-related proteins by activating the AKT/Nrf2 pathway, thereby suppressing the apoptosis of SN4741 cells induced by N-methyl-4-phenylpyridinium Iodide (MPP<sup>+</sup>). On the other hand, IAL inhibited LPS-induced release of pro-inflammatory mediators in BV2 cells by activating the AKT/Nrf2/HO-1 pathway and inhibiting the NF-κB pathway. In addition, IAL protected SN4741 from microglial activation-mediated neurotoxicity. Taken together, these results highlight the beneficial role of IAL as a novel therapy and potential PD drug due to its pharmacological profile. |
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| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T00:25:20Z |
| publishDate | 2022-09-01 |
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| spelling | doaj.art-09995e26c28a4a2e8d8e20f20b600d832023-11-23T15:34:34ZengMDPI AGCells2073-44092022-09-011118292710.3390/cells11182927Isoalantolactone (IAL) Regulates Neuro-Inflammation and Neuronal Apoptosis to Curb Pathology of Parkinson’s DiseaseDewei He0Yanting Liu1Jie Li2Hefei Wang3Bojian Ye4Yuan He5Zhe Li6Xiyu Gao7Shoupeng Fu8Dianfeng Liu9College of Animal Science, Jilin University, Changchun 130012, ChinaDepartment of Neurosurgery, Seoul St. Mary’s Hospital, College of Medicine, Catholic University of Korea, Seoul 296-12, KoreaCollege of Animal Science, Jilin University, Changchun 130012, ChinaCollege of Veterinary Medicine, Jilin University, Changchun 130012, ChinaCollege of Veterinary Medicine, Jilin University, Changchun 130012, ChinaCollege of Veterinary Medicine, Jilin University, Changchun 130012, ChinaCollege of Veterinary Medicine, Jilin University, Changchun 130012, ChinaCollege of Animal Science, Jilin University, Changchun 130012, ChinaCollege of Veterinary Medicine, Jilin University, Changchun 130012, ChinaCollege of Animal Science, Jilin University, Changchun 130012, ChinaParkinson’s disease (PD) is a neurodegenerative disease in which neuronal apoptosis and associated inflammation are involved in its pathogenesis. However, there is still no specific treatment that can stop PD progression. Isoalantolactone (IAL) plays a role in many inflammation-related diseases. However, its effect and mechanism in PD remain unclear. In this study, results showed that IAL administration ameliorated 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced PD-related pathological impairment and decreased motor activity in mice. Results from in vitro mechanistic studies showed that IAL regulated apoptosis-related proteins by activating the AKT/Nrf2 pathway, thereby suppressing the apoptosis of SN4741 cells induced by N-methyl-4-phenylpyridinium Iodide (MPP<sup>+</sup>). On the other hand, IAL inhibited LPS-induced release of pro-inflammatory mediators in BV2 cells by activating the AKT/Nrf2/HO-1 pathway and inhibiting the NF-κB pathway. In addition, IAL protected SN4741 from microglial activation-mediated neurotoxicity. Taken together, these results highlight the beneficial role of IAL as a novel therapy and potential PD drug due to its pharmacological profile.https://www.mdpi.com/2073-4409/11/18/2927isoalantolactonePDneuro-protectionneuro-inflammationapoptosis |
| spellingShingle | Dewei He Yanting Liu Jie Li Hefei Wang Bojian Ye Yuan He Zhe Li Xiyu Gao Shoupeng Fu Dianfeng Liu Isoalantolactone (IAL) Regulates Neuro-Inflammation and Neuronal Apoptosis to Curb Pathology of Parkinson’s Disease Cells isoalantolactone PD neuro-protection neuro-inflammation apoptosis |
| title | Isoalantolactone (IAL) Regulates Neuro-Inflammation and Neuronal Apoptosis to Curb Pathology of Parkinson’s Disease |
| title_full | Isoalantolactone (IAL) Regulates Neuro-Inflammation and Neuronal Apoptosis to Curb Pathology of Parkinson’s Disease |
| title_fullStr | Isoalantolactone (IAL) Regulates Neuro-Inflammation and Neuronal Apoptosis to Curb Pathology of Parkinson’s Disease |
| title_full_unstemmed | Isoalantolactone (IAL) Regulates Neuro-Inflammation and Neuronal Apoptosis to Curb Pathology of Parkinson’s Disease |
| title_short | Isoalantolactone (IAL) Regulates Neuro-Inflammation and Neuronal Apoptosis to Curb Pathology of Parkinson’s Disease |
| title_sort | isoalantolactone ial regulates neuro inflammation and neuronal apoptosis to curb pathology of parkinson s disease |
| topic | isoalantolactone PD neuro-protection neuro-inflammation apoptosis |
| url | https://www.mdpi.com/2073-4409/11/18/2927 |
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