Estimating intervention effectiveness in trials of malaria interventions with contamination

Estimating intervention effectiveness in trials of malaria interventions with contamination

Abstract Background In cluster randomized trials (CRTs) or stepped wedge cluster randomized trials (SWCRTs) of malaria interventions, mosquito movement leads to contamination between trial arms unless buffer zones separate the clusters. Contamination can be accounted for in the analysis, yielding an...

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Bibliographic Details
Main Authors: Lea Multerer, Fiona Vanobberghen, Tracy R. Glass, Alexandra Hiscox, Steven W. Lindsay, Willem Takken, Alfred Tiono, Thomas Smith
Format: Article
Language:English
Published: BMC 2021-10-01
Series:Malaria Journal
Subjects:
Stepped wedge cluster randomized trial
Contamination
Sigmoid random effects model
Contamination range
Effective coverage
Malaria
Online Access:https://doi.org/10.1186/s12936-021-03924-7

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