DNA oxidation-based analysis: A new approach to assessing the relationship between nutrition and cancer
DNA oxidation is one of the essential destructive effects of reactive oxygen species (ROS) on the cell membrane macromolecules leading to the deformation of cellular DNA. The most abundant oxidative DNA product on which most studies have focused is re-oxidized DNA, 8 oxo-deoxyguanosine (8-oxod...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2022-11-01
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| Series: | Basic & Clinical Cancer Research |
| Subjects: | |
| Online Access: | https://bccr.tums.ac.ir/index.php/bccrj/article/view/427 |
| _version_ | 1811195804578217984 |
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| author | Mehdi Karimi Kamran Roudini Abolfazl Zendehdel Fatemeh Toorang Soraiya Ebrahimpour-Koujan |
| author_facet | Mehdi Karimi Kamran Roudini Abolfazl Zendehdel Fatemeh Toorang Soraiya Ebrahimpour-Koujan |
| author_sort | Mehdi Karimi |
| collection | DOAJ |
| description |
DNA oxidation is one of the essential destructive effects of reactive oxygen species (ROS) on the cell membrane macromolecules leading to the deformation of cellular DNA. The most abundant oxidative DNA product on which most studies have focused is re-oxidized DNA, 8 oxo-deoxyguanosine (8-oxodG). This deformation of cellular DNA is associated with various cancer initiation and progression. DNA damage can be a cancer marker including 8-oxodG, thymidine glycol, 8-oxoadenine, etc. DNA oxidation is affected by environmental and non-environmental factors. Age, diet, and metabolism are at the heart of this process. This review study summarizes the types of cancer-related DNA oxidation that serve as a cancer biomarker. Also we will look at the factors influencing their formation.
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| first_indexed | 2024-04-12T00:48:50Z |
| format | Article |
| id | doaj.art-099ab6c9469b4ed49503d90f43b4366f |
| institution | Directory Open Access Journal |
| issn | 2228-6527 2228-5466 |
| language | English |
| last_indexed | 2024-04-12T00:48:50Z |
| publishDate | 2022-11-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Basic & Clinical Cancer Research |
| spelling | doaj.art-099ab6c9469b4ed49503d90f43b4366f2022-12-22T03:54:47ZengTehran University of Medical SciencesBasic & Clinical Cancer Research2228-65272228-54662022-11-01134DNA oxidation-based analysis: A new approach to assessing the relationship between nutrition and cancerMehdi Karimi0Kamran Roudini1Abolfazl Zendehdel2Fatemeh Toorang3Soraiya Ebrahimpour-Koujan41Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, IranDepartment of Internal Medicine, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, IranGeriatric Department, Associate Professor of Internal Medicine, Ziaeian Hospital, Tehran University of Medical Sciences, Tehran, IranDepartment of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, IranCancer Research Center of Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran DNA oxidation is one of the essential destructive effects of reactive oxygen species (ROS) on the cell membrane macromolecules leading to the deformation of cellular DNA. The most abundant oxidative DNA product on which most studies have focused is re-oxidized DNA, 8 oxo-deoxyguanosine (8-oxodG). This deformation of cellular DNA is associated with various cancer initiation and progression. DNA damage can be a cancer marker including 8-oxodG, thymidine glycol, 8-oxoadenine, etc. DNA oxidation is affected by environmental and non-environmental factors. Age, diet, and metabolism are at the heart of this process. This review study summarizes the types of cancer-related DNA oxidation that serve as a cancer biomarker. Also we will look at the factors influencing their formation. https://bccr.tums.ac.ir/index.php/bccrj/article/view/427DNAOxidative damageCancerMutation |
| spellingShingle | Mehdi Karimi Kamran Roudini Abolfazl Zendehdel Fatemeh Toorang Soraiya Ebrahimpour-Koujan DNA oxidation-based analysis: A new approach to assessing the relationship between nutrition and cancer Basic & Clinical Cancer Research DNA Oxidative damage Cancer Mutation |
| title | DNA oxidation-based analysis: A new approach to assessing the relationship between nutrition and cancer |
| title_full | DNA oxidation-based analysis: A new approach to assessing the relationship between nutrition and cancer |
| title_fullStr | DNA oxidation-based analysis: A new approach to assessing the relationship between nutrition and cancer |
| title_full_unstemmed | DNA oxidation-based analysis: A new approach to assessing the relationship between nutrition and cancer |
| title_short | DNA oxidation-based analysis: A new approach to assessing the relationship between nutrition and cancer |
| title_sort | dna oxidation based analysis a new approach to assessing the relationship between nutrition and cancer |
| topic | DNA Oxidative damage Cancer Mutation |
| url | https://bccr.tums.ac.ir/index.php/bccrj/article/view/427 |
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