Rapid evolution of an adaptive multicellular morphology of Candida auris during systemic infection
Abstract Candida auris has become a serious threat to public health. The mechanisms of how this fungal pathogen adapts to the mammalian host are poorly understood. Here we report the rapid evolution of an adaptive C. auris multicellular aggregative morphology in the murine host during systemic infec...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-46786-8 |
| _version_ | 1827315885097877504 |
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| author | Jian Bing Zhangyue Guan Tianhong Zheng Craig L. Ennis Clarissa J. Nobile Changbin Chen Haiqing Chu Guanghua Huang |
| author_facet | Jian Bing Zhangyue Guan Tianhong Zheng Craig L. Ennis Clarissa J. Nobile Changbin Chen Haiqing Chu Guanghua Huang |
| author_sort | Jian Bing |
| collection | DOAJ |
| description | Abstract Candida auris has become a serious threat to public health. The mechanisms of how this fungal pathogen adapts to the mammalian host are poorly understood. Here we report the rapid evolution of an adaptive C. auris multicellular aggregative morphology in the murine host during systemic infection. C. auris aggregative cells accumulate in the brain and exhibit obvious advantages over the single-celled yeast-form cells during systemic infection. Genetic mutations, specifically de novo point mutations in genes associated with cell division or budding processes, underlie the rapid evolution of this aggregative phenotype. Most mutated C. auris genes are associated with the regulation of cell wall integrity, cytokinesis, cytoskeletal properties, and cellular polarization. Moreover, the multicellular aggregates are notably more recalcitrant to the host antimicrobial peptides LL-37 and PACAP relative to the single-celled yeast-form cells. Overall, to survive in the host, C. auris can rapidly evolve a multicellular aggregative morphology via genetic mutations. |
| first_indexed | 2024-04-24T23:04:25Z |
| format | Article |
| id | doaj.art-099b87f379a74efc8a5e94fad6c2fc4e |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-24T23:04:25Z |
| publishDate | 2024-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-099b87f379a74efc8a5e94fad6c2fc4e2024-03-17T12:32:07ZengNature PortfolioNature Communications2041-17232024-03-0115111910.1038/s41467-024-46786-8Rapid evolution of an adaptive multicellular morphology of Candida auris during systemic infectionJian Bing0Zhangyue Guan1Tianhong Zheng2Craig L. Ennis3Clarissa J. Nobile4Changbin Chen5Haiqing Chu6Guanghua Huang7Shanghai Institute of Infectious Disease and Biosecurity, Department of infectious diseases, Huashan Hospital and State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan UniversityShanghai Institute of Infectious Disease and Biosecurity, Department of infectious diseases, Huashan Hospital and State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan UniversityShanghai Institute of Infectious Disease and Biosecurity, Department of infectious diseases, Huashan Hospital and State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan UniversityDepartment of Molecular and Cell Biology, University of California, MercedDepartment of Molecular and Cell Biology, University of California, MercedThe Center for Microbes, Development, and Health, Key Laboratory of Molecular Virology and Immunology, Unit of Pathogenic Fungal Infection & Host Immunity, Shanghai Institute of Immunity and Infection, Chinese Academy of SciencesDepartment of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji UniversityShanghai Institute of Infectious Disease and Biosecurity, Department of infectious diseases, Huashan Hospital and State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan UniversityAbstract Candida auris has become a serious threat to public health. The mechanisms of how this fungal pathogen adapts to the mammalian host are poorly understood. Here we report the rapid evolution of an adaptive C. auris multicellular aggregative morphology in the murine host during systemic infection. C. auris aggregative cells accumulate in the brain and exhibit obvious advantages over the single-celled yeast-form cells during systemic infection. Genetic mutations, specifically de novo point mutations in genes associated with cell division or budding processes, underlie the rapid evolution of this aggregative phenotype. Most mutated C. auris genes are associated with the regulation of cell wall integrity, cytokinesis, cytoskeletal properties, and cellular polarization. Moreover, the multicellular aggregates are notably more recalcitrant to the host antimicrobial peptides LL-37 and PACAP relative to the single-celled yeast-form cells. Overall, to survive in the host, C. auris can rapidly evolve a multicellular aggregative morphology via genetic mutations.https://doi.org/10.1038/s41467-024-46786-8 |
| spellingShingle | Jian Bing Zhangyue Guan Tianhong Zheng Craig L. Ennis Clarissa J. Nobile Changbin Chen Haiqing Chu Guanghua Huang Rapid evolution of an adaptive multicellular morphology of Candida auris during systemic infection Nature Communications |
| title | Rapid evolution of an adaptive multicellular morphology of Candida auris during systemic infection |
| title_full | Rapid evolution of an adaptive multicellular morphology of Candida auris during systemic infection |
| title_fullStr | Rapid evolution of an adaptive multicellular morphology of Candida auris during systemic infection |
| title_full_unstemmed | Rapid evolution of an adaptive multicellular morphology of Candida auris during systemic infection |
| title_short | Rapid evolution of an adaptive multicellular morphology of Candida auris during systemic infection |
| title_sort | rapid evolution of an adaptive multicellular morphology of candida auris during systemic infection |
| url | https://doi.org/10.1038/s41467-024-46786-8 |
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