Prognostic value of high-frequency oscillations combined with multimodal imaging methods for epilepsy surgery
Abstract. Background:. The combination of high-frequency oscillations (HFOs) with single-mode imaging methods has been proved useful in identifying epileptogenic zones, whereas few studies have examined HFOs combined with multimodal imaging methods. The aim of this study was to evaluate the prognos...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer
2022-05-01
|
| Series: | Chinese Medical Journal |
| Online Access: | http://journals.lww.com/10.1097/CM9.0000000000001909 |
| _version_ | 1818096835156246528 |
|---|---|
| author | Xiaoming Yan Fangzhao Yin Cuiping Xu Tao Yu Xiaonan Li Wei Wang Xi Zhang Kai Ma Guojun Zhang Lishao Guo |
| author_facet | Xiaoming Yan Fangzhao Yin Cuiping Xu Tao Yu Xiaonan Li Wei Wang Xi Zhang Kai Ma Guojun Zhang Lishao Guo |
| author_sort | Xiaoming Yan |
| collection | DOAJ |
| description | Abstract.
Background:. The combination of high-frequency oscillations (HFOs) with single-mode imaging methods has been proved useful in identifying epileptogenic zones, whereas few studies have examined HFOs combined with multimodal imaging methods. The aim of this study was to evaluate the prognostic value of ripples, an HFO subtype with a frequency of 80 to 200 Hz is combined with multimodal imaging methods in predicting epilepsy surgery outcome.
Methods:. HFOs were analyzed in 21 consecutive medically refractory epilepsy patients who underwent epilepsy surgery. All patients underwent positron emission tomography (PET) and deep electrode implantation for stereo-electroencephalography (SEEG); 11 patients underwent magnetoencephalography (MEG). Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy in predicting surgical outcome were calculated for ripples combined with PET, MEG, both PET and MEG, and PET combined with MEG. Kaplan-Meier survival analyses were conducted in each group to estimate prognostic value.
Results:. The study included 13 men and 8 women. Accuracy for ripples, PET, and MEG alone in predicting surgical outcome was 42.9%, 42.9%, and 81.8%, respectively. Accuracy for ripples combined with PET and MEG was the highest. Resection of regions identified by ripples, MEG dipoles, and combined PET findings was significantly associated with better surgical outcome (P < 0.05).
Conclusions:. Intracranial electrodes are essential to detect regions which generate ripples and to remove these areas which indicate good surgical outcome for medically intractable epilepsy. With the assistance of presurgical noninvasive imaging examinations, PET and MEG, for example, the SEEG electrodes would identify epileptogenic regions more effectively. |
| first_indexed | 2024-12-10T23:10:56Z |
| format | Article |
| id | doaj.art-099f67f779b642f5a26522499187da24 |
| institution | Directory Open Access Journal |
| issn | 0366-6999 2542-5641 |
| language | English |
| last_indexed | 2024-12-10T23:10:56Z |
| publishDate | 2022-05-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Chinese Medical Journal |
| spelling | doaj.art-099f67f779b642f5a26522499187da242022-12-22T01:29:57ZengWolters KluwerChinese Medical Journal0366-69992542-56412022-05-0113591087109510.1097/CM9.0000000000001909202205050-00012Prognostic value of high-frequency oscillations combined with multimodal imaging methods for epilepsy surgeryXiaoming YanFangzhao YinCuiping XuTao YuXiaonan LiWei WangXi ZhangKai MaGuojun ZhangLishao GuoAbstract. Background:. The combination of high-frequency oscillations (HFOs) with single-mode imaging methods has been proved useful in identifying epileptogenic zones, whereas few studies have examined HFOs combined with multimodal imaging methods. The aim of this study was to evaluate the prognostic value of ripples, an HFO subtype with a frequency of 80 to 200 Hz is combined with multimodal imaging methods in predicting epilepsy surgery outcome. Methods:. HFOs were analyzed in 21 consecutive medically refractory epilepsy patients who underwent epilepsy surgery. All patients underwent positron emission tomography (PET) and deep electrode implantation for stereo-electroencephalography (SEEG); 11 patients underwent magnetoencephalography (MEG). Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy in predicting surgical outcome were calculated for ripples combined with PET, MEG, both PET and MEG, and PET combined with MEG. Kaplan-Meier survival analyses were conducted in each group to estimate prognostic value. Results:. The study included 13 men and 8 women. Accuracy for ripples, PET, and MEG alone in predicting surgical outcome was 42.9%, 42.9%, and 81.8%, respectively. Accuracy for ripples combined with PET and MEG was the highest. Resection of regions identified by ripples, MEG dipoles, and combined PET findings was significantly associated with better surgical outcome (P < 0.05). Conclusions:. Intracranial electrodes are essential to detect regions which generate ripples and to remove these areas which indicate good surgical outcome for medically intractable epilepsy. With the assistance of presurgical noninvasive imaging examinations, PET and MEG, for example, the SEEG electrodes would identify epileptogenic regions more effectively.http://journals.lww.com/10.1097/CM9.0000000000001909 |
| spellingShingle | Xiaoming Yan Fangzhao Yin Cuiping Xu Tao Yu Xiaonan Li Wei Wang Xi Zhang Kai Ma Guojun Zhang Lishao Guo Prognostic value of high-frequency oscillations combined with multimodal imaging methods for epilepsy surgery Chinese Medical Journal |
| title | Prognostic value of high-frequency oscillations combined with multimodal imaging methods for epilepsy surgery |
| title_full | Prognostic value of high-frequency oscillations combined with multimodal imaging methods for epilepsy surgery |
| title_fullStr | Prognostic value of high-frequency oscillations combined with multimodal imaging methods for epilepsy surgery |
| title_full_unstemmed | Prognostic value of high-frequency oscillations combined with multimodal imaging methods for epilepsy surgery |
| title_short | Prognostic value of high-frequency oscillations combined with multimodal imaging methods for epilepsy surgery |
| title_sort | prognostic value of high frequency oscillations combined with multimodal imaging methods for epilepsy surgery |
| url | http://journals.lww.com/10.1097/CM9.0000000000001909 |
| work_keys_str_mv | AT xiaomingyan prognosticvalueofhighfrequencyoscillationscombinedwithmultimodalimagingmethodsforepilepsysurgery AT fangzhaoyin prognosticvalueofhighfrequencyoscillationscombinedwithmultimodalimagingmethodsforepilepsysurgery AT cuipingxu prognosticvalueofhighfrequencyoscillationscombinedwithmultimodalimagingmethodsforepilepsysurgery AT taoyu prognosticvalueofhighfrequencyoscillationscombinedwithmultimodalimagingmethodsforepilepsysurgery AT xiaonanli prognosticvalueofhighfrequencyoscillationscombinedwithmultimodalimagingmethodsforepilepsysurgery AT weiwang prognosticvalueofhighfrequencyoscillationscombinedwithmultimodalimagingmethodsforepilepsysurgery AT xizhang prognosticvalueofhighfrequencyoscillationscombinedwithmultimodalimagingmethodsforepilepsysurgery AT kaima prognosticvalueofhighfrequencyoscillationscombinedwithmultimodalimagingmethodsforepilepsysurgery AT guojunzhang prognosticvalueofhighfrequencyoscillationscombinedwithmultimodalimagingmethodsforepilepsysurgery AT lishaoguo prognosticvalueofhighfrequencyoscillationscombinedwithmultimodalimagingmethodsforepilepsysurgery |