Vall d’Hebron Risk Score II for myocardial infarction and cardiac death
Objectives The aim of this study was to create a new Vall d’Hebron Risk Score-II (VH-RS-II) for non-fatal myocardial infarction (MI) and/or cardiac death (CD), excluding patients with coronary revascularisation (CR) during the follow-up.Methods We analysed 5215 consecutive patients underwent gated s...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2023-11-01
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| Series: | Open Heart |
| Online Access: | https://openheart.bmj.com/content/10/2/e002431.full |
| _version_ | 1827391472546086912 |
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| author | Santiago Aguadé-Bruix Guillermo Romero-Farina Ignacio Ferreira González |
| author_facet | Santiago Aguadé-Bruix Guillermo Romero-Farina Ignacio Ferreira González |
| author_sort | Santiago Aguadé-Bruix |
| collection | DOAJ |
| description | Objectives The aim of this study was to create a new Vall d’Hebron Risk Score-II (VH-RS-II) for non-fatal myocardial infarction (MI) and/or cardiac death (CD), excluding patients with coronary revascularisation (CR) during the follow-up.Methods We analysed 5215 consecutive patients underwent gated single photon emission CT (SPECT); 2960 patients (age 64.2±11, male 58.1%) had no previous MI and/or CR, and 2255 patients (age 63.3±11, male 81.9%) had previous MI and/or CR. During a follow-up of 4.3±2.6 years, the cardiac event (MI and CD) was evaluated. This study was reviewed and approved by the ethics committee of our institution (number form trial register, PR(AG)168.2012). To obtain the predictor model, multivariate Cox regression analysis and multivariate logistic regression analysis were used. RS-VH-II was validated with 679 patients.Results In patients without previous MI and/or CR, age (HR: 1.01; p<0.001), diabetes (HR: 2.1, p=0.001), metabolic equivalent (METs) (HR: 0.89, p=0.038), ST segment depression (HR: 1.4, p=0.011), ejection fraction (EF) (HR: 0.97, p<0.001) and summed stress score (HR: 1.2, p<0.001) were the independent predictors of CE (C-statistic: 0.8). In patients with previous MI and/or CR, age (HR: 1.06, p<0.001), male (HR: 1.9, p=0.047), smoker (HR: 1.5, p=0.047), METs (HR: 0.8, p<0.001), ST segment depression (HR: 1.4, p=0.002), EF (HR: 0.96; p<0.001) and summed difference score (HR: 1.03, p=0.06) were the independent predictors of CE (C-statistic:0.8).Conclusion The VH-RS-II obtained from different clinical exercise and gated SPECT variables allow the risk stratification for MI and CD in patients with or without previous MI and/or CR in due form. |
| first_indexed | 2024-03-08T17:11:27Z |
| format | Article |
| id | doaj.art-09a09ae2c49247968d30c15c7e87be06 |
| institution | Directory Open Access Journal |
| issn | 2053-3624 |
| language | English |
| last_indexed | 2024-03-08T17:11:27Z |
| publishDate | 2023-11-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | Open Heart |
| spelling | doaj.art-09a09ae2c49247968d30c15c7e87be062024-01-03T21:20:07ZengBMJ Publishing GroupOpen Heart2053-36242023-11-0110210.1136/openhrt-2023-002431Vall d’Hebron Risk Score II for myocardial infarction and cardiac deathSantiago Aguadé-Bruix0Guillermo Romero-Farina1Ignacio Ferreira González2Nuclear Cardiology, Department, Hospital Universitari Vall d`Hebron, Vall d’Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, SpainNuclear Cardiology, Department, Hospital Universitari Vall d`Hebron, Vall d’Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, SpainCardiology Department, Hospital Universitari Vall d`Hebron, Valld’Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, SpainObjectives The aim of this study was to create a new Vall d’Hebron Risk Score-II (VH-RS-II) for non-fatal myocardial infarction (MI) and/or cardiac death (CD), excluding patients with coronary revascularisation (CR) during the follow-up.Methods We analysed 5215 consecutive patients underwent gated single photon emission CT (SPECT); 2960 patients (age 64.2±11, male 58.1%) had no previous MI and/or CR, and 2255 patients (age 63.3±11, male 81.9%) had previous MI and/or CR. During a follow-up of 4.3±2.6 years, the cardiac event (MI and CD) was evaluated. This study was reviewed and approved by the ethics committee of our institution (number form trial register, PR(AG)168.2012). To obtain the predictor model, multivariate Cox regression analysis and multivariate logistic regression analysis were used. RS-VH-II was validated with 679 patients.Results In patients without previous MI and/or CR, age (HR: 1.01; p<0.001), diabetes (HR: 2.1, p=0.001), metabolic equivalent (METs) (HR: 0.89, p=0.038), ST segment depression (HR: 1.4, p=0.011), ejection fraction (EF) (HR: 0.97, p<0.001) and summed stress score (HR: 1.2, p<0.001) were the independent predictors of CE (C-statistic: 0.8). In patients with previous MI and/or CR, age (HR: 1.06, p<0.001), male (HR: 1.9, p=0.047), smoker (HR: 1.5, p=0.047), METs (HR: 0.8, p<0.001), ST segment depression (HR: 1.4, p=0.002), EF (HR: 0.96; p<0.001) and summed difference score (HR: 1.03, p=0.06) were the independent predictors of CE (C-statistic:0.8).Conclusion The VH-RS-II obtained from different clinical exercise and gated SPECT variables allow the risk stratification for MI and CD in patients with or without previous MI and/or CR in due form.https://openheart.bmj.com/content/10/2/e002431.full |
| spellingShingle | Santiago Aguadé-Bruix Guillermo Romero-Farina Ignacio Ferreira González Vall d’Hebron Risk Score II for myocardial infarction and cardiac death Open Heart |
| title | Vall d’Hebron Risk Score II for myocardial infarction and cardiac death |
| title_full | Vall d’Hebron Risk Score II for myocardial infarction and cardiac death |
| title_fullStr | Vall d’Hebron Risk Score II for myocardial infarction and cardiac death |
| title_full_unstemmed | Vall d’Hebron Risk Score II for myocardial infarction and cardiac death |
| title_short | Vall d’Hebron Risk Score II for myocardial infarction and cardiac death |
| title_sort | vall d hebron risk score ii for myocardial infarction and cardiac death |
| url | https://openheart.bmj.com/content/10/2/e002431.full |
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