Molecular Mechanisms of MYCN Dysregulation in Cancers

Molecular Mechanisms of MYCN Dysregulation in Cancers

MYCN, a member of MYC proto-oncogene family, encodes a basic helix-loop-helix transcription factor N-MYC. Abnormal expression of N-MYC is correlated with high-risk cancers and poor prognosis. Initially identified as an amplified oncogene in neuroblastoma in 1983, the oncogenic effect of N-MYC is exp...

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Bibliographic Details
Main Authors: Ruochen Liu, Pengfei Shi, Zhongze Wang, Chaoyu Yuan, Hongjuan Cui
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Oncology
Subjects:
MYCN
cancer
gene amplification
G-quadruplex
NCYM
super enhancer
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.625332/full

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