Animal Models for the Study of Keratoconus
Keratoconus (KC) is characterized by localized, central thinning and cone-like protrusion of the cornea. Its precise etiology remains undetermined, although both genetic and environmental factors are known to contribute to disease susceptibility. Due to KC’s complex nature, there is currently no ide...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/23/2681 |
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| author | Rachel Hadvina Amy Estes Yutao Liu |
| author_facet | Rachel Hadvina Amy Estes Yutao Liu |
| author_sort | Rachel Hadvina |
| collection | DOAJ |
| description | Keratoconus (KC) is characterized by localized, central thinning and cone-like protrusion of the cornea. Its precise etiology remains undetermined, although both genetic and environmental factors are known to contribute to disease susceptibility. Due to KC’s complex nature, there is currently no ideal animal model to represent both the corneal phenotype and underlying pathophysiology. Attempts to establish a KC model have involved mice, rats, and rabbits, with some additional novel animals suggested. Genetic animal models have only been attempted in mice. Similarly, spontaneously occurring animal models for KC have only been discovered in mice. Models generated using chemical or environmental treatments have been attempted in mice, rats, and rabbits. Among several methods used to induce KC in animals, ultraviolet radiation exposure and treatment with collagenase are some of the most prevalent. There is a clear need for an experimental model animal to elucidate the underlying mechanisms behind the development and progression of keratoconus. An appropriate animal model could also aid in the development of treatments to slow or arrest the disorder. |
| first_indexed | 2024-03-09T01:53:28Z |
| format | Article |
| id | doaj.art-09a24b52e9954741956fae6126f83dac |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T01:53:28Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-09a24b52e9954741956fae6126f83dac2023-12-08T15:13:02ZengMDPI AGCells2073-44092023-11-011223268110.3390/cells12232681Animal Models for the Study of KeratoconusRachel Hadvina0Amy Estes1Yutao Liu2Department of Cellular Biology & Anatomy, Augusta University, 1120 15th Street, Augusta, GA 30912, USAJames & Jean Culver Vision Discovery Institute, Medical College of Georgia, Augusta University, 1120 15th Street, Augusta, GA 30912, USADepartment of Cellular Biology & Anatomy, Augusta University, 1120 15th Street, Augusta, GA 30912, USAKeratoconus (KC) is characterized by localized, central thinning and cone-like protrusion of the cornea. Its precise etiology remains undetermined, although both genetic and environmental factors are known to contribute to disease susceptibility. Due to KC’s complex nature, there is currently no ideal animal model to represent both the corneal phenotype and underlying pathophysiology. Attempts to establish a KC model have involved mice, rats, and rabbits, with some additional novel animals suggested. Genetic animal models have only been attempted in mice. Similarly, spontaneously occurring animal models for KC have only been discovered in mice. Models generated using chemical or environmental treatments have been attempted in mice, rats, and rabbits. Among several methods used to induce KC in animals, ultraviolet radiation exposure and treatment with collagenase are some of the most prevalent. There is a clear need for an experimental model animal to elucidate the underlying mechanisms behind the development and progression of keratoconus. An appropriate animal model could also aid in the development of treatments to slow or arrest the disorder.https://www.mdpi.com/2073-4409/12/23/2681keratoconuscorneaanimal modelsmicerabbitkeratocytes |
| spellingShingle | Rachel Hadvina Amy Estes Yutao Liu Animal Models for the Study of Keratoconus Cells keratoconus cornea animal models mice rabbit keratocytes |
| title | Animal Models for the Study of Keratoconus |
| title_full | Animal Models for the Study of Keratoconus |
| title_fullStr | Animal Models for the Study of Keratoconus |
| title_full_unstemmed | Animal Models for the Study of Keratoconus |
| title_short | Animal Models for the Study of Keratoconus |
| title_sort | animal models for the study of keratoconus |
| topic | keratoconus cornea animal models mice rabbit keratocytes |
| url | https://www.mdpi.com/2073-4409/12/23/2681 |
| work_keys_str_mv | AT rachelhadvina animalmodelsforthestudyofkeratoconus AT amyestes animalmodelsforthestudyofkeratoconus AT yutaoliu animalmodelsforthestudyofkeratoconus |