Implication of Platelets in Immuno-Thrombosis and Thrombo-Inflammation
In addition to their well-described hemostatic function, platelets are active participants in innate and adaptive immunity. Inflammation and immunity are closely related to changes in platelet reactions and enhanced platelet function in thrombo-inflammation, as well as in microbial and virus infecti...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-03-01
|
| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.863846/full |
| _version_ | 1811332059282538496 |
|---|---|
| author | Younes Zaid Younes Zaid Yahye Merhi |
| author_facet | Younes Zaid Younes Zaid Yahye Merhi |
| author_sort | Younes Zaid |
| collection | DOAJ |
| description | In addition to their well-described hemostatic function, platelets are active participants in innate and adaptive immunity. Inflammation and immunity are closely related to changes in platelet reactions and enhanced platelet function in thrombo-inflammation, as well as in microbial and virus infections. A platelet’s immune function is incompletely understood, but an important balance exists between its protective and pathogenic responses and its thrombotic and inflammatory functions. As the mediator of vascular homeostasis, platelets interact with neutrophils, bacteria and virus by expressing specific receptors and releasing granules, transferring RNA, and secreting mitochondria, which controls hemostasis and thrombosis, infection, and innate and adaptive immunity. This review focuses on the involvement of platelets during immuno-thrombosis and thrombo-inflammation. |
| first_indexed | 2024-04-13T16:30:10Z |
| format | Article |
| id | doaj.art-09a472781f1b4edd9566c7902d4d25be |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-13T16:30:10Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-09a472781f1b4edd9566c7902d4d25be2022-12-22T02:39:35ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-03-01910.3389/fcvm.2022.863846863846Implication of Platelets in Immuno-Thrombosis and Thrombo-InflammationYounes Zaid0Younes Zaid1Yahye Merhi2Laboratory of Materials, Nanotechnology and Environment, Faculty of Sciences, Mohammed V University in Rabat, Rabat, MoroccoImmunology and Biodiversity Laboratory, Department of Biology, Faculty of Sciences, Hassan II University, Casablanca, MoroccoLaboratory of Thrombosis and Hemostasis, Montreal Heart Institute, Research Center, The Université de Montréal, Montreal, QC, CanadaIn addition to their well-described hemostatic function, platelets are active participants in innate and adaptive immunity. Inflammation and immunity are closely related to changes in platelet reactions and enhanced platelet function in thrombo-inflammation, as well as in microbial and virus infections. A platelet’s immune function is incompletely understood, but an important balance exists between its protective and pathogenic responses and its thrombotic and inflammatory functions. As the mediator of vascular homeostasis, platelets interact with neutrophils, bacteria and virus by expressing specific receptors and releasing granules, transferring RNA, and secreting mitochondria, which controls hemostasis and thrombosis, infection, and innate and adaptive immunity. This review focuses on the involvement of platelets during immuno-thrombosis and thrombo-inflammation.https://www.frontiersin.org/articles/10.3389/fcvm.2022.863846/fullplateletsimmuno-thrombosisthrombo-inflammationNETosisextracellular vesicles (EVs) |
| spellingShingle | Younes Zaid Younes Zaid Yahye Merhi Implication of Platelets in Immuno-Thrombosis and Thrombo-Inflammation Frontiers in Cardiovascular Medicine platelets immuno-thrombosis thrombo-inflammation NETosis extracellular vesicles (EVs) |
| title | Implication of Platelets in Immuno-Thrombosis and Thrombo-Inflammation |
| title_full | Implication of Platelets in Immuno-Thrombosis and Thrombo-Inflammation |
| title_fullStr | Implication of Platelets in Immuno-Thrombosis and Thrombo-Inflammation |
| title_full_unstemmed | Implication of Platelets in Immuno-Thrombosis and Thrombo-Inflammation |
| title_short | Implication of Platelets in Immuno-Thrombosis and Thrombo-Inflammation |
| title_sort | implication of platelets in immuno thrombosis and thrombo inflammation |
| topic | platelets immuno-thrombosis thrombo-inflammation NETosis extracellular vesicles (EVs) |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.863846/full |
| work_keys_str_mv | AT youneszaid implicationofplateletsinimmunothrombosisandthromboinflammation AT youneszaid implicationofplateletsinimmunothrombosisandthromboinflammation AT yahyemerhi implicationofplateletsinimmunothrombosisandthromboinflammation |