Birth of monozygotic dichorionic twins after a single blastocyst embryo transfer: a case report of genetic determination of zygosity
Objective: To report a case of monozygotic dichorionic (DC) twins after a single cryopreserved blastocyst embryo transfer followed by genetic determination of zygosity postpartum. Design: Case report. Setting: University hospital. Patients: A 26-year-old woman with polycystic ovary syndrome and her...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | F&S Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666334123000338 |
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| author | Neli Semrl, M.D. Michael Barth, M.D. Sarah Feigl, M.D. Rüdiger Hochstätter, M.D. Irmgard Oreskovic, M.Sc. Herbert Fluhr, M.D., M.H.B.A. Philipp Klaritsch, M.D. Irene Speicher, M.D. Martina Kollmann, M.D., Ph.D. |
| author_facet | Neli Semrl, M.D. Michael Barth, M.D. Sarah Feigl, M.D. Rüdiger Hochstätter, M.D. Irmgard Oreskovic, M.Sc. Herbert Fluhr, M.D., M.H.B.A. Philipp Klaritsch, M.D. Irene Speicher, M.D. Martina Kollmann, M.D., Ph.D. |
| author_sort | Neli Semrl, M.D. |
| collection | DOAJ |
| description | Objective: To report a case of monozygotic dichorionic (DC) twins after a single cryopreserved blastocyst embryo transfer followed by genetic determination of zygosity postpartum. Design: Case report. Setting: University hospital. Patients: A 26-year-old woman with polycystic ovary syndrome and her 36-year-old male partner with severe oligozoospermia, resulting in a 1.5-year history of primary infertility. Interventions: Controlled ovarian stimulation and intracytoplasmic sperm injection treatment with single cryopreserved embryo transfer at blastocyst stage. Main Outcome Measures: Ultrasound images of the fetuses and short tandem repeat genotyping postpartum. Results: A DC twin pregnancy following a single cryopreserved blastocyst embryo transfer was confirmed at the first trimester screening. Confirmatory testing performed postpartum included short tandem repeat analysis determining monozygosity and pathology examination reporting DC placental configuration. Conclusions: Dichorionic monozygotic twins are thought to arise from the splitting of an embryo before the blastocyst stage. This case suggests that placental configuration of monozygotic twins may not strictly depend on timing of embryo division. Genetic analysis is the only tool to confirm the zygosity. |
| first_indexed | 2024-03-13T05:09:34Z |
| format | Article |
| id | doaj.art-09a5d37c24544aadbeb33112048ead03 |
| institution | Directory Open Access Journal |
| issn | 2666-3341 |
| language | English |
| last_indexed | 2024-03-13T05:09:34Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | F&S Reports |
| spelling | doaj.art-09a5d37c24544aadbeb33112048ead032023-06-16T05:11:47ZengElsevierF&S Reports2666-33412023-06-0142231234Birth of monozygotic dichorionic twins after a single blastocyst embryo transfer: a case report of genetic determination of zygosityNeli Semrl, M.D.0Michael Barth, M.D.1Sarah Feigl, M.D.2Rüdiger Hochstätter, M.D.3Irmgard Oreskovic, M.Sc.4Herbert Fluhr, M.D., M.H.B.A.5Philipp Klaritsch, M.D.6Irene Speicher, M.D.7Martina Kollmann, M.D., Ph.D.8Department of Obstetrics and Gynecology, Medical University of Graz, AustriaDepartment of Obstetrics and Gynecology, Medical University of Graz, AustriaDepartment of Obstetrics and Gynecology, Medical University of Graz, AustriaDepartment of Obstetrics and Gynecology, Medical University of Graz, AustriaDepartment of Obstetrics and Gynecology, Medical University of Graz, AustriaDepartment of Obstetrics and Gynecology, Medical University of Graz, AustriaDepartment of Obstetrics and Gynecology, Medical University of Graz, AustriaThe Diagnostic and Research Institute of Pathology, Medical University of Graz, AustriaDepartment of Obstetrics and Gynecology, Medical University of Graz, Austria; Correspondence: Martina Kollmann, M.D., Ph.D., Department of Obstetrics and Gynecology, Medical University of Graz, Auenbruggerplatz 14 Graz 8036, AustriaObjective: To report a case of monozygotic dichorionic (DC) twins after a single cryopreserved blastocyst embryo transfer followed by genetic determination of zygosity postpartum. Design: Case report. Setting: University hospital. Patients: A 26-year-old woman with polycystic ovary syndrome and her 36-year-old male partner with severe oligozoospermia, resulting in a 1.5-year history of primary infertility. Interventions: Controlled ovarian stimulation and intracytoplasmic sperm injection treatment with single cryopreserved embryo transfer at blastocyst stage. Main Outcome Measures: Ultrasound images of the fetuses and short tandem repeat genotyping postpartum. Results: A DC twin pregnancy following a single cryopreserved blastocyst embryo transfer was confirmed at the first trimester screening. Confirmatory testing performed postpartum included short tandem repeat analysis determining monozygosity and pathology examination reporting DC placental configuration. Conclusions: Dichorionic monozygotic twins are thought to arise from the splitting of an embryo before the blastocyst stage. This case suggests that placental configuration of monozygotic twins may not strictly depend on timing of embryo division. Genetic analysis is the only tool to confirm the zygosity.http://www.sciencedirect.com/science/article/pii/S2666334123000338ICSIsingle blastocyst embryo transfermonozygotic dichorionic twinsDNA analysis |
| spellingShingle | Neli Semrl, M.D. Michael Barth, M.D. Sarah Feigl, M.D. Rüdiger Hochstätter, M.D. Irmgard Oreskovic, M.Sc. Herbert Fluhr, M.D., M.H.B.A. Philipp Klaritsch, M.D. Irene Speicher, M.D. Martina Kollmann, M.D., Ph.D. Birth of monozygotic dichorionic twins after a single blastocyst embryo transfer: a case report of genetic determination of zygosity F&S Reports ICSI single blastocyst embryo transfer monozygotic dichorionic twins DNA analysis |
| title | Birth of monozygotic dichorionic twins after a single blastocyst embryo transfer: a case report of genetic determination of zygosity |
| title_full | Birth of monozygotic dichorionic twins after a single blastocyst embryo transfer: a case report of genetic determination of zygosity |
| title_fullStr | Birth of monozygotic dichorionic twins after a single blastocyst embryo transfer: a case report of genetic determination of zygosity |
| title_full_unstemmed | Birth of monozygotic dichorionic twins after a single blastocyst embryo transfer: a case report of genetic determination of zygosity |
| title_short | Birth of monozygotic dichorionic twins after a single blastocyst embryo transfer: a case report of genetic determination of zygosity |
| title_sort | birth of monozygotic dichorionic twins after a single blastocyst embryo transfer a case report of genetic determination of zygosity |
| topic | ICSI single blastocyst embryo transfer monozygotic dichorionic twins DNA analysis |
| url | http://www.sciencedirect.com/science/article/pii/S2666334123000338 |
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