MESENCHYMAL STEM CELLS AS A THERAPEUTIC STRATEGY FOR MULTIPLE SCLEROSIS: ISSUES AND PERSPECTIVES
The ability of mesenchymal stem cells (MSC) to influence the regulatory/suppressive effect in the autoimmune process and promote remyelination allows to consider them a new method of multiple sclerosis (MS) therapy, by means of modifying the disease activity. Genetic stability, proliferative potenti...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2017-01-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/1392 |
| _version_ | 1797704834713911296 |
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| author | M. M. Zafranskaya D. B. Nizhegorodova |
| author_facet | M. M. Zafranskaya D. B. Nizhegorodova |
| author_sort | M. M. Zafranskaya |
| collection | DOAJ |
| description | The ability of mesenchymal stem cells (MSC) to influence the regulatory/suppressive effect in the autoimmune process and promote remyelination allows to consider them a new method of multiple sclerosis (MS) therapy, by means of modifying the disease activity. Genetic stability, proliferative potential, ability to migrate into the damaged tissue areas and agreed protocols for isolation and culture are the main advantages for successful autologous, as well as allogeneic MSC therapy. Preliminary results from clinical studies using MSC application in MS patients show efficiency and safety of this therapeutic approach. Nevertheless, successful demonstration of the cell therapy in MS is only possible after detailed analysis and understanding of MSC biology and mechanisms of appropriate intercellular interactions. The article reviews general experience in usage of immunomodulatory and neuroprotective properties of MSС in MS, and highlights the issues of validity in cell-based therapy taking into account both in vitro и in vivo studies. |
| first_indexed | 2024-03-12T05:27:20Z |
| format | Article |
| id | doaj.art-09a65d974296442c83c4670d465e5c55 |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-03-12T05:27:20Z |
| publishDate | 2017-01-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-09a65d974296442c83c4670d465e5c552023-09-03T07:15:12ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2017-01-0119668370410.15789/1563-0625-2017-6-683-704963MESENCHYMAL STEM CELLS AS A THERAPEUTIC STRATEGY FOR MULTIPLE SCLEROSIS: ISSUES AND PERSPECTIVESM. M. Zafranskaya0D. B. Nizhegorodova1International Sakharov Environmental Institute, Belorussian State University; Belorussian Medical Academy for Postgraduate EducationInternational Sakharov Environmental Institute, Belorussian State University; Belorussian Medical Academy for Postgraduate EducationThe ability of mesenchymal stem cells (MSC) to influence the regulatory/suppressive effect in the autoimmune process and promote remyelination allows to consider them a new method of multiple sclerosis (MS) therapy, by means of modifying the disease activity. Genetic stability, proliferative potential, ability to migrate into the damaged tissue areas and agreed protocols for isolation and culture are the main advantages for successful autologous, as well as allogeneic MSC therapy. Preliminary results from clinical studies using MSC application in MS patients show efficiency and safety of this therapeutic approach. Nevertheless, successful demonstration of the cell therapy in MS is only possible after detailed analysis and understanding of MSC biology and mechanisms of appropriate intercellular interactions. The article reviews general experience in usage of immunomodulatory and neuroprotective properties of MSС in MS, and highlights the issues of validity in cell-based therapy taking into account both in vitro и in vivo studies.https://www.mimmun.ru/mimmun/article/view/1392mesenchymal stem cellsmultiple sclerosiscell-based therapy |
| spellingShingle | M. M. Zafranskaya D. B. Nizhegorodova MESENCHYMAL STEM CELLS AS A THERAPEUTIC STRATEGY FOR MULTIPLE SCLEROSIS: ISSUES AND PERSPECTIVES Медицинская иммунология mesenchymal stem cells multiple sclerosis cell-based therapy |
| title | MESENCHYMAL STEM CELLS AS A THERAPEUTIC STRATEGY FOR MULTIPLE SCLEROSIS: ISSUES AND PERSPECTIVES |
| title_full | MESENCHYMAL STEM CELLS AS A THERAPEUTIC STRATEGY FOR MULTIPLE SCLEROSIS: ISSUES AND PERSPECTIVES |
| title_fullStr | MESENCHYMAL STEM CELLS AS A THERAPEUTIC STRATEGY FOR MULTIPLE SCLEROSIS: ISSUES AND PERSPECTIVES |
| title_full_unstemmed | MESENCHYMAL STEM CELLS AS A THERAPEUTIC STRATEGY FOR MULTIPLE SCLEROSIS: ISSUES AND PERSPECTIVES |
| title_short | MESENCHYMAL STEM CELLS AS A THERAPEUTIC STRATEGY FOR MULTIPLE SCLEROSIS: ISSUES AND PERSPECTIVES |
| title_sort | mesenchymal stem cells as a therapeutic strategy for multiple sclerosis issues and perspectives |
| topic | mesenchymal stem cells multiple sclerosis cell-based therapy |
| url | https://www.mimmun.ru/mimmun/article/view/1392 |
| work_keys_str_mv | AT mmzafranskaya mesenchymalstemcellsasatherapeuticstrategyformultiplesclerosisissuesandperspectives AT dbnizhegorodova mesenchymalstemcellsasatherapeuticstrategyformultiplesclerosisissuesandperspectives |