Laryngeal extra-skeletal Ewing sarcoma treated with DC-CTL immunotherapy: A case report and review of the literature
Extra-skeletal Ewing sarcoma (EES) is a rare sarcoma composed primarily of small round cells, capable of metastasizing and relapsing. Few cases of EES originating from the larynx have been reported, and no publications regarding laryngeal EES treated with dendritic cells-cytotoxic T lymphocytes (DC-...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1003393/full |
| _version_ | 1797986687171690496 |
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| author | Hanrui Wang Hanrui Wang Jianwei Wang Jianwei Wang Qiang Wang Qiang Wang Yujuan Yang Yujuan Yang Jing Guo Jing Guo Chao Ren Chao Ren Chao Ren Yakui Mou Yakui Mou Chuanliang Jia Chuanliang Jia Xicheng Song Xicheng Song Xicheng Song |
| author_facet | Hanrui Wang Hanrui Wang Jianwei Wang Jianwei Wang Qiang Wang Qiang Wang Yujuan Yang Yujuan Yang Jing Guo Jing Guo Chao Ren Chao Ren Chao Ren Yakui Mou Yakui Mou Chuanliang Jia Chuanliang Jia Xicheng Song Xicheng Song Xicheng Song |
| author_sort | Hanrui Wang |
| collection | DOAJ |
| description | Extra-skeletal Ewing sarcoma (EES) is a rare sarcoma composed primarily of small round cells, capable of metastasizing and relapsing. Few cases of EES originating from the larynx have been reported, and no publications regarding laryngeal EES treated with dendritic cells-cytotoxic T lymphocytes (DC-CTL) immunotherapy have been found. We described a 29-year-old woman with a mass found in the larynx. Diffuse small round cells with scanty cytoplasm shown by histology test and extremely positive staining of CD99 revealed by immunohistochemistry helped determine the diagnosis of laryngeal EES. The patient survived for seven years with no signs of recurrence or metastasis after six cycles of DC-CTL immunotherapy based on traditional treatments. This case indicates that DC-CTL immunotherapy could be considered a new option for treating EES. |
| first_indexed | 2024-04-11T07:37:01Z |
| format | Article |
| id | doaj.art-09a7be22e72c4e29a7e0b4afb62a54d3 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-11T07:37:01Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-09a7be22e72c4e29a7e0b4afb62a54d32022-12-22T04:36:43ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-11-011210.3389/fonc.2022.10033931003393Laryngeal extra-skeletal Ewing sarcoma treated with DC-CTL immunotherapy: A case report and review of the literatureHanrui Wang0Hanrui Wang1Jianwei Wang2Jianwei Wang3Qiang Wang4Qiang Wang5Yujuan Yang6Yujuan Yang7Jing Guo8Jing Guo9Chao Ren10Chao Ren11Chao Ren12Yakui Mou13Yakui Mou14Chuanliang Jia15Chuanliang Jia16Xicheng Song17Xicheng Song18Xicheng Song19Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, ChinaShandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai, ChinaDepartment of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, ChinaShandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai, ChinaDepartment of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, ChinaShandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai, ChinaDepartment of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, ChinaShandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai, ChinaDepartment of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, ChinaShandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai, ChinaDepartment of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, ChinaShandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai, ChinaShandong Provincial Innovation and Practice Base for Postdoctors, Yantai Yuhuangding Hospital, Yantai, ChinaDepartment of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, ChinaShandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai, ChinaDepartment of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, ChinaShandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai, ChinaDepartment of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, ChinaShandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai, ChinaShandong Provincial Innovation and Practice Base for Postdoctors, Yantai Yuhuangding Hospital, Yantai, ChinaExtra-skeletal Ewing sarcoma (EES) is a rare sarcoma composed primarily of small round cells, capable of metastasizing and relapsing. Few cases of EES originating from the larynx have been reported, and no publications regarding laryngeal EES treated with dendritic cells-cytotoxic T lymphocytes (DC-CTL) immunotherapy have been found. We described a 29-year-old woman with a mass found in the larynx. Diffuse small round cells with scanty cytoplasm shown by histology test and extremely positive staining of CD99 revealed by immunohistochemistry helped determine the diagnosis of laryngeal EES. The patient survived for seven years with no signs of recurrence or metastasis after six cycles of DC-CTL immunotherapy based on traditional treatments. This case indicates that DC-CTL immunotherapy could be considered a new option for treating EES.https://www.frontiersin.org/articles/10.3389/fonc.2022.1003393/fulllarynxsurgeryprognosisimmunotherapyextra-skeletal Ewing sarcoma |
| spellingShingle | Hanrui Wang Hanrui Wang Jianwei Wang Jianwei Wang Qiang Wang Qiang Wang Yujuan Yang Yujuan Yang Jing Guo Jing Guo Chao Ren Chao Ren Chao Ren Yakui Mou Yakui Mou Chuanliang Jia Chuanliang Jia Xicheng Song Xicheng Song Xicheng Song Laryngeal extra-skeletal Ewing sarcoma treated with DC-CTL immunotherapy: A case report and review of the literature Frontiers in Oncology larynx surgery prognosis immunotherapy extra-skeletal Ewing sarcoma |
| title | Laryngeal extra-skeletal Ewing sarcoma treated with DC-CTL immunotherapy: A case report and review of the literature |
| title_full | Laryngeal extra-skeletal Ewing sarcoma treated with DC-CTL immunotherapy: A case report and review of the literature |
| title_fullStr | Laryngeal extra-skeletal Ewing sarcoma treated with DC-CTL immunotherapy: A case report and review of the literature |
| title_full_unstemmed | Laryngeal extra-skeletal Ewing sarcoma treated with DC-CTL immunotherapy: A case report and review of the literature |
| title_short | Laryngeal extra-skeletal Ewing sarcoma treated with DC-CTL immunotherapy: A case report and review of the literature |
| title_sort | laryngeal extra skeletal ewing sarcoma treated with dc ctl immunotherapy a case report and review of the literature |
| topic | larynx surgery prognosis immunotherapy extra-skeletal Ewing sarcoma |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1003393/full |
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