Evaluation of gabapentin and dexamethasone alone or in combination for pain control after adenotonsillectomy in children
Background: Different methods and many drugs have been used to control the post-operative pain. In this study, we evaluate the role of gabapentin premedication and/or dexamethasone in management of post-operative pain following adenotonsillectomy in children. Materials and Methods: In a double-blind...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2014-01-01
|
| Series: | Saudi Journal of Anaesthesia |
| Subjects: | |
| Online Access: | http://www.saudija.org/article.asp?issn=1658-354X;year=2014;volume=8;issue=3;spage=317;epage=322;aulast=Amin |
| _version_ | 1811229277103849472 |
|---|---|
| author | Sabry Mohammad Amin |
| author_facet | Sabry Mohammad Amin |
| author_sort | Sabry Mohammad Amin |
| collection | DOAJ |
| description | Background: Different methods and many drugs have been used to control the post-operative pain. In this study, we evaluate the role of gabapentin premedication and/or dexamethasone in management of post-operative pain following adenotonsillectomy in children. Materials and Methods: In a double-blind randomized study, 120 children were subjected for adenotonsillectomy classified into three equal groups. Group G: Gabapentin 10 mg/kg was given orally 2 h before induction of anesthesia (Gabapentin syrup 250 mg/5 ml. Group D: Children in this group received placebo pre-operatively and received dexamethasone 0.15 mg/kg intravenously after induction of anesthesia, but before surgery. Group C: Children in this group received combination of oral gabapentin 10 mg/kg 2 h before induction of anesthesia and intra-operative 0.15 mg/kg dexamethasone intravenously. All children underwent general anesthesia. Pain score was assisted post-operatively 2 h, 4 h, 6 h, 8 h, 12 h and 18 h after recovery using face, legs, activity, cry, consolability scale. Results: Pain score in Group C and Group G was significantly less at 4 h, 6 h and 8 h post-operatively than in Group D (P < 0.05). At 12 h, the pain score in Group C was significantly less than Group G and Group D (P < 0.05). And no significant changes were observed in pain score at 18 h post-operatively between all groups (P > 0.05). The time to first analgesia was longer in the Group C than in Group G and Group D and the time to first analgesia was significantly longer in Group G than in Group D (P < 0.05). The total amount of pethidine was less in Group C and Group G than in Group D (P < 0.05). The incidence of post-operative nausea and vomiting was statically insignificant among all groups and no reported post-operative bleeding. Conclusion: Gabapentin 10 mg/kg premedication combined with intra-operative dexamethasone 0.15 mg/kg prolongs the post-operative analgesia following adenotonsillectomy in children and decreases the amount of pethidine used post-operatively with no reported adverse effects or increase in the incidence of post-operative bleeding. |
| first_indexed | 2024-04-12T10:11:50Z |
| format | Article |
| id | doaj.art-09a9482111914184bb315da7a2b5aac3 |
| institution | Directory Open Access Journal |
| issn | 1658-354X |
| language | English |
| last_indexed | 2024-04-12T10:11:50Z |
| publishDate | 2014-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Saudi Journal of Anaesthesia |
| spelling | doaj.art-09a9482111914184bb315da7a2b5aac32022-12-22T03:37:17ZengWolters Kluwer Medknow PublicationsSaudi Journal of Anaesthesia1658-354X2014-01-018331732210.4103/1658-354X.136417Evaluation of gabapentin and dexamethasone alone or in combination for pain control after adenotonsillectomy in childrenSabry Mohammad AminBackground: Different methods and many drugs have been used to control the post-operative pain. In this study, we evaluate the role of gabapentin premedication and/or dexamethasone in management of post-operative pain following adenotonsillectomy in children. Materials and Methods: In a double-blind randomized study, 120 children were subjected for adenotonsillectomy classified into three equal groups. Group G: Gabapentin 10 mg/kg was given orally 2 h before induction of anesthesia (Gabapentin syrup 250 mg/5 ml. Group D: Children in this group received placebo pre-operatively and received dexamethasone 0.15 mg/kg intravenously after induction of anesthesia, but before surgery. Group C: Children in this group received combination of oral gabapentin 10 mg/kg 2 h before induction of anesthesia and intra-operative 0.15 mg/kg dexamethasone intravenously. All children underwent general anesthesia. Pain score was assisted post-operatively 2 h, 4 h, 6 h, 8 h, 12 h and 18 h after recovery using face, legs, activity, cry, consolability scale. Results: Pain score in Group C and Group G was significantly less at 4 h, 6 h and 8 h post-operatively than in Group D (P < 0.05). At 12 h, the pain score in Group C was significantly less than Group G and Group D (P < 0.05). And no significant changes were observed in pain score at 18 h post-operatively between all groups (P > 0.05). The time to first analgesia was longer in the Group C than in Group G and Group D and the time to first analgesia was significantly longer in Group G than in Group D (P < 0.05). The total amount of pethidine was less in Group C and Group G than in Group D (P < 0.05). The incidence of post-operative nausea and vomiting was statically insignificant among all groups and no reported post-operative bleeding. Conclusion: Gabapentin 10 mg/kg premedication combined with intra-operative dexamethasone 0.15 mg/kg prolongs the post-operative analgesia following adenotonsillectomy in children and decreases the amount of pethidine used post-operatively with no reported adverse effects or increase in the incidence of post-operative bleeding.http://www.saudija.org/article.asp?issn=1658-354X;year=2014;volume=8;issue=3;spage=317;epage=322;aulast=AminAdenotonsillectomydexamethasonegabapentinpost-operative painpost-tonsillectomy bleeding |
| spellingShingle | Sabry Mohammad Amin Evaluation of gabapentin and dexamethasone alone or in combination for pain control after adenotonsillectomy in children Saudi Journal of Anaesthesia Adenotonsillectomy dexamethasone gabapentin post-operative pain post-tonsillectomy bleeding |
| title | Evaluation of gabapentin and dexamethasone alone or in combination for pain control after adenotonsillectomy in children |
| title_full | Evaluation of gabapentin and dexamethasone alone or in combination for pain control after adenotonsillectomy in children |
| title_fullStr | Evaluation of gabapentin and dexamethasone alone or in combination for pain control after adenotonsillectomy in children |
| title_full_unstemmed | Evaluation of gabapentin and dexamethasone alone or in combination for pain control after adenotonsillectomy in children |
| title_short | Evaluation of gabapentin and dexamethasone alone or in combination for pain control after adenotonsillectomy in children |
| title_sort | evaluation of gabapentin and dexamethasone alone or in combination for pain control after adenotonsillectomy in children |
| topic | Adenotonsillectomy dexamethasone gabapentin post-operative pain post-tonsillectomy bleeding |
| url | http://www.saudija.org/article.asp?issn=1658-354X;year=2014;volume=8;issue=3;spage=317;epage=322;aulast=Amin |
| work_keys_str_mv | AT sabrymohammadamin evaluationofgabapentinanddexamethasonealoneorincombinationforpaincontrolafteradenotonsillectomyinchildren |