Benzyl Alcohol/Salicylaldehyde-Type Polyketide Metabolites of Fungi: Sources, Biosynthesis, Biological Activities, and Synthesis
Marine microorganisms are an important source of natural polyketides, which have become a significant reservoir of lead structures for drug design due to their diverse biological activities. In this review, we provide a summary of the resources, structures, biological activities, and proposed biosyn...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1660-3397/21/1/19 |
| _version_ | 1797439384893521920 |
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| author | Mária Štiblariková Angelika Lásiková Tibor Gracza |
| author_facet | Mária Štiblariková Angelika Lásiková Tibor Gracza |
| author_sort | Mária Štiblariková |
| collection | DOAJ |
| description | Marine microorganisms are an important source of natural polyketides, which have become a significant reservoir of lead structures for drug design due to their diverse biological activities. In this review, we provide a summary of the resources, structures, biological activities, and proposed biosynthetic pathways of the benzyl alcohol/salicylaldehyde-type polyketides. In addition, the total syntheses of these secondary metabolites from their discoveries to the present day are presented. This review could be helpful for researchers in the total synthesis of complex natural products and the use of polyketide bioactive molecules for pharmacological purposes and applications in medicinal chemistry. |
| first_indexed | 2024-03-09T11:52:05Z |
| format | Article |
| id | doaj.art-09aa6999a876406c8fbb87e00ddbb363 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-09T11:52:05Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-09aa6999a876406c8fbb87e00ddbb3632023-11-30T23:13:22ZengMDPI AGMarine Drugs1660-33972022-12-012111910.3390/md21010019Benzyl Alcohol/Salicylaldehyde-Type Polyketide Metabolites of Fungi: Sources, Biosynthesis, Biological Activities, and SynthesisMária Štiblariková0Angelika Lásiková1Tibor Gracza2Department of Organic Chemistry, Institute of Organic Chemistry, Catalysis and Petrochemistry, Slovak University of Technology, Radlinskeho 9, SK-812 37 Bratislava, SlovakiaDepartment of Organic Chemistry, Institute of Organic Chemistry, Catalysis and Petrochemistry, Slovak University of Technology, Radlinskeho 9, SK-812 37 Bratislava, SlovakiaDepartment of Organic Chemistry, Institute of Organic Chemistry, Catalysis and Petrochemistry, Slovak University of Technology, Radlinskeho 9, SK-812 37 Bratislava, SlovakiaMarine microorganisms are an important source of natural polyketides, which have become a significant reservoir of lead structures for drug design due to their diverse biological activities. In this review, we provide a summary of the resources, structures, biological activities, and proposed biosynthetic pathways of the benzyl alcohol/salicylaldehyde-type polyketides. In addition, the total syntheses of these secondary metabolites from their discoveries to the present day are presented. This review could be helpful for researchers in the total synthesis of complex natural products and the use of polyketide bioactive molecules for pharmacological purposes and applications in medicinal chemistry.https://www.mdpi.com/1660-3397/21/1/19natural productsnatural polyketidessecondary metabolitesbiological activitybiosynthesistotal synthesis |
| spellingShingle | Mária Štiblariková Angelika Lásiková Tibor Gracza Benzyl Alcohol/Salicylaldehyde-Type Polyketide Metabolites of Fungi: Sources, Biosynthesis, Biological Activities, and Synthesis Marine Drugs natural products natural polyketides secondary metabolites biological activity biosynthesis total synthesis |
| title | Benzyl Alcohol/Salicylaldehyde-Type Polyketide Metabolites of Fungi: Sources, Biosynthesis, Biological Activities, and Synthesis |
| title_full | Benzyl Alcohol/Salicylaldehyde-Type Polyketide Metabolites of Fungi: Sources, Biosynthesis, Biological Activities, and Synthesis |
| title_fullStr | Benzyl Alcohol/Salicylaldehyde-Type Polyketide Metabolites of Fungi: Sources, Biosynthesis, Biological Activities, and Synthesis |
| title_full_unstemmed | Benzyl Alcohol/Salicylaldehyde-Type Polyketide Metabolites of Fungi: Sources, Biosynthesis, Biological Activities, and Synthesis |
| title_short | Benzyl Alcohol/Salicylaldehyde-Type Polyketide Metabolites of Fungi: Sources, Biosynthesis, Biological Activities, and Synthesis |
| title_sort | benzyl alcohol salicylaldehyde type polyketide metabolites of fungi sources biosynthesis biological activities and synthesis |
| topic | natural products natural polyketides secondary metabolites biological activity biosynthesis total synthesis |
| url | https://www.mdpi.com/1660-3397/21/1/19 |
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