The organoid: A research model for ovarian cancer
Epithelial ovarian cancer (EOC) is a heterogeneous disease with a variety of distinct clinical and molecular characteristics. The currently available and common research models for EOC include tumor cell lines and patient-derived xenografts. However, these models have certain shortcomings: establish...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Tzu-Chi Medical Journal |
| Subjects: | |
| Online Access: | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2022;volume=34;issue=3;spage=255;epage=260;aulast= |
| _version_ | 1818478495870746624 |
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| author | Yu-Hsun Chang Kun-Chi Wu Tomor Harnod Dah-Ching Ding |
| author_facet | Yu-Hsun Chang Kun-Chi Wu Tomor Harnod Dah-Ching Ding |
| author_sort | Yu-Hsun Chang |
| collection | DOAJ |
| description | Epithelial ovarian cancer (EOC) is a heterogeneous disease with a variety of distinct clinical and molecular characteristics. The currently available and common research models for EOC include tumor cell lines and patient-derived xenografts. However, these models have certain shortcomings: establishing a cell line is time-consuming, loss of genetic traits after long-term culture is a possibility, and investment is required in terms of animal care facilities. Therefore, better research models are required. Organoid technology was originally developed from colorectal cancer. Tumor organoid is a three-dimensional culture system and can help accurately recapture the tumor phenotype from the original tumor. Tumor organoid systems can overcome the above-mentioned shortcomings of the currently available research models. The organoid model can be used for culturing ovarian cancer subtypes, screening drugs, assessing genomes, and establishing biobanks. However, the currently available organoid models can only culture one type of cells, epithelial cells. Therefore, an organoid-on-a-chip device can be developed in the future to provide a microenvironment for cell–cell, cell–matrix, and cell–media interactions. Thus, organoid models can be used in ovarian cancer research and can generate a simulated in vivo system, enabling studies on the heterogeneity of ovarian cancer. |
| first_indexed | 2024-12-10T09:49:04Z |
| format | Article |
| id | doaj.art-09ab1c4a2a704e59b6008429d41b713c |
| institution | Directory Open Access Journal |
| issn | 1016-3190 2223-8956 |
| language | English |
| last_indexed | 2024-12-10T09:49:04Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Tzu-Chi Medical Journal |
| spelling | doaj.art-09ab1c4a2a704e59b6008429d41b713c2022-12-22T01:53:43ZengWolters Kluwer Medknow PublicationsTzu-Chi Medical Journal1016-31902223-89562022-01-0134325526010.4103/tcmj.tcmj_63_21The organoid: A research model for ovarian cancerYu-Hsun ChangKun-Chi WuTomor HarnodDah-Ching DingEpithelial ovarian cancer (EOC) is a heterogeneous disease with a variety of distinct clinical and molecular characteristics. The currently available and common research models for EOC include tumor cell lines and patient-derived xenografts. However, these models have certain shortcomings: establishing a cell line is time-consuming, loss of genetic traits after long-term culture is a possibility, and investment is required in terms of animal care facilities. Therefore, better research models are required. Organoid technology was originally developed from colorectal cancer. Tumor organoid is a three-dimensional culture system and can help accurately recapture the tumor phenotype from the original tumor. Tumor organoid systems can overcome the above-mentioned shortcomings of the currently available research models. The organoid model can be used for culturing ovarian cancer subtypes, screening drugs, assessing genomes, and establishing biobanks. However, the currently available organoid models can only culture one type of cells, epithelial cells. Therefore, an organoid-on-a-chip device can be developed in the future to provide a microenvironment for cell–cell, cell–matrix, and cell–media interactions. Thus, organoid models can be used in ovarian cancer research and can generate a simulated in vivo system, enabling studies on the heterogeneity of ovarian cancer.http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2022;volume=34;issue=3;spage=255;epage=260;aulast=epithelial cellsepithelial ovarian cancerorganoid-on-a-chippatient-derived xenograftsxenograft |
| spellingShingle | Yu-Hsun Chang Kun-Chi Wu Tomor Harnod Dah-Ching Ding The organoid: A research model for ovarian cancer Tzu-Chi Medical Journal epithelial cells epithelial ovarian cancer organoid-on-a-chip patient-derived xenografts xenograft |
| title | The organoid: A research model for ovarian cancer |
| title_full | The organoid: A research model for ovarian cancer |
| title_fullStr | The organoid: A research model for ovarian cancer |
| title_full_unstemmed | The organoid: A research model for ovarian cancer |
| title_short | The organoid: A research model for ovarian cancer |
| title_sort | organoid a research model for ovarian cancer |
| topic | epithelial cells epithelial ovarian cancer organoid-on-a-chip patient-derived xenografts xenograft |
| url | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2022;volume=34;issue=3;spage=255;epage=260;aulast= |
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