Three Divergent Subpopulations of the Malaria Parasite Plasmodium knowlesi
Multilocus microsatellite genotyping of Plasmodium knowlesi isolates previously indicated 2 divergent parasite subpopulations in humans on the island of Borneo, each associated with a different macaque reservoir host species. Geographic divergence was also apparent, and independent sequence data hav...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2017-04-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/23/4/16-1738_article |
| _version_ | 1818495560688074752 |
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| author | Paul C.S. Divis Lee C. Lin Jeffrine J. Rovie-Ryan Khamisah A. Kadir Fread Anderios Shamilah Hisam Reuben S.K. Sharma Balbir Singh David J. Conway |
| author_facet | Paul C.S. Divis Lee C. Lin Jeffrine J. Rovie-Ryan Khamisah A. Kadir Fread Anderios Shamilah Hisam Reuben S.K. Sharma Balbir Singh David J. Conway |
| author_sort | Paul C.S. Divis |
| collection | DOAJ |
| description | Multilocus microsatellite genotyping of Plasmodium knowlesi isolates previously indicated 2 divergent parasite subpopulations in humans on the island of Borneo, each associated with a different macaque reservoir host species. Geographic divergence was also apparent, and independent sequence data have indicated particularly deep divergence between parasites from mainland Southeast Asia and Borneo. To resolve the overall population structure, multilocus microsatellite genotyping was conducted on a new sample of 182 P. knowlesi infections (obtained from 134 humans and 48 wild macaques) from diverse areas of Malaysia, first analyzed separately and then in combination with previous data. All analyses confirmed 2 divergent clusters of human cases in Malaysian Borneo, associated with long-tailed macaques and pig-tailed macaques, and a third cluster in humans and most macaques in peninsular Malaysia. High levels of pairwise divergence between each of these sympatric and allopatric subpopulations have implications for the epidemiology and control of this zoonotic species. |
| first_indexed | 2024-12-10T18:22:07Z |
| format | Article |
| id | doaj.art-09abb5661ac740f392e869681a2c7c4b |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-10T18:22:07Z |
| publishDate | 2017-04-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-09abb5661ac740f392e869681a2c7c4b2022-12-22T01:38:10ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592017-04-0123461662410.3201/eid2304.161738Three Divergent Subpopulations of the Malaria Parasite Plasmodium knowlesiPaul C.S. DivisLee C. LinJeffrine J. Rovie-RyanKhamisah A. KadirFread AnderiosShamilah HisamReuben S.K. SharmaBalbir SinghDavid J. ConwayMultilocus microsatellite genotyping of Plasmodium knowlesi isolates previously indicated 2 divergent parasite subpopulations in humans on the island of Borneo, each associated with a different macaque reservoir host species. Geographic divergence was also apparent, and independent sequence data have indicated particularly deep divergence between parasites from mainland Southeast Asia and Borneo. To resolve the overall population structure, multilocus microsatellite genotyping was conducted on a new sample of 182 P. knowlesi infections (obtained from 134 humans and 48 wild macaques) from diverse areas of Malaysia, first analyzed separately and then in combination with previous data. All analyses confirmed 2 divergent clusters of human cases in Malaysian Borneo, associated with long-tailed macaques and pig-tailed macaques, and a third cluster in humans and most macaques in peninsular Malaysia. High levels of pairwise divergence between each of these sympatric and allopatric subpopulations have implications for the epidemiology and control of this zoonotic species.https://wwwnc.cdc.gov/eid/article/23/4/16-1738_articlePlasmodium knowlesireservoir hostsmicrosatellite genotypesgeographical divergenceMalaysiaparasites |
| spellingShingle | Paul C.S. Divis Lee C. Lin Jeffrine J. Rovie-Ryan Khamisah A. Kadir Fread Anderios Shamilah Hisam Reuben S.K. Sharma Balbir Singh David J. Conway Three Divergent Subpopulations of the Malaria Parasite Plasmodium knowlesi Emerging Infectious Diseases Plasmodium knowlesi reservoir hosts microsatellite genotypes geographical divergence Malaysia parasites |
| title | Three Divergent Subpopulations of the Malaria Parasite Plasmodium knowlesi |
| title_full | Three Divergent Subpopulations of the Malaria Parasite Plasmodium knowlesi |
| title_fullStr | Three Divergent Subpopulations of the Malaria Parasite Plasmodium knowlesi |
| title_full_unstemmed | Three Divergent Subpopulations of the Malaria Parasite Plasmodium knowlesi |
| title_short | Three Divergent Subpopulations of the Malaria Parasite Plasmodium knowlesi |
| title_sort | three divergent subpopulations of the malaria parasite plasmodium knowlesi |
| topic | Plasmodium knowlesi reservoir hosts microsatellite genotypes geographical divergence Malaysia parasites |
| url | https://wwwnc.cdc.gov/eid/article/23/4/16-1738_article |
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