Assessment of brain structure and volume reveals neurodevelopmental abnormalities in preterm infants with low-grade intraventricular hemorrhage
Abstract There is increasing evidence of abnormal neurodevelopmental outcomes in preterm infants with low-grade intraventricular hemorrhage (IVH). The purpose of the study was to explore whether brain microstructure and volume are associated with neuro-behavioral outcomes at 40 weeks corrected gesta...
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Nature Portfolio
2024-03-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-56148-5 |
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| author | Chunxiang Zhang Zitao Zhu Kaiyu Wang Brianna F. Moon Bohao Zhang Yanyong Shen Zihe Wang Xin Zhao Xiaoan Zhang |
| author_facet | Chunxiang Zhang Zitao Zhu Kaiyu Wang Brianna F. Moon Bohao Zhang Yanyong Shen Zihe Wang Xin Zhao Xiaoan Zhang |
| author_sort | Chunxiang Zhang |
| collection | DOAJ |
| description | Abstract There is increasing evidence of abnormal neurodevelopmental outcomes in preterm infants with low-grade intraventricular hemorrhage (IVH). The purpose of the study was to explore whether brain microstructure and volume are associated with neuro-behavioral outcomes at 40 weeks corrected gestational age in preterm infants with low-grade IVH. MR imaging at term-equivalent age (TEA) was performed in 25 preterm infants with mild IVH (Papile grading I/II) and 40 control subjects without IVH. These subjects all had neonatal behavioral neurological assessment (NBNA) at 40 weeks’ corrected age. Microstructure and volume evaluation of the brain were performed by using diffusion kurtosis imaging (DKI) and Synthetic MRI. Correlations among microstructure parameters, volume, and developmental outcomes were explored by using Spearman's correlation. In preterm infants with low-grade IVH, the volume of brain parenchymal fraction (BPF) was reduced. In addition, mean kurtosis (MK), fractional anisotropy (FA), radial kurtosis (RK), axial kurtosis (AK) in several major brain regions were reduced, while mean diffusivity (MD) was increased (P < 0.05). BPF, RK in the cerebellum, MK in the genu of the corpus callosum, and MK in the thalamus of preterm infants with low-grade IVH were associated with lower NBNA scores (r = 0.831, 0.836, 0.728, 0.772, P < 0.05). DKI and Synthetic MRI can quantitatively evaluate the microstructure alterations and brain volumes in preterm infants with low-grade IVH, which provides clinicians with a more comprehensive and accurate neurobehavioral assessment of preterm infants with low-grade IVH. |
| first_indexed | 2024-04-25T01:06:42Z |
| format | Article |
| id | doaj.art-09ac1fcbc2bb40bca227e1fb97c051b7 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-25T01:06:42Z |
| publishDate | 2024-03-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj.art-09ac1fcbc2bb40bca227e1fb97c051b72024-03-10T12:11:28ZengNature PortfolioScientific Reports2045-23222024-03-0114111010.1038/s41598-024-56148-5Assessment of brain structure and volume reveals neurodevelopmental abnormalities in preterm infants with low-grade intraventricular hemorrhageChunxiang Zhang0Zitao Zhu1Kaiyu Wang2Brianna F. Moon3Bohao Zhang4Yanyong Shen5Zihe Wang6Xin Zhao7Xiaoan Zhang8Department of Radiology, The Third Affiliated Hospital of Zhengzhou UniversityWuhan UniversityGE Healthcare, MR Research ChinaDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical SchoolInstitute of Neuroscience, Zhengzhou UniversityDepartment of Radiology, The Third Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityDepartment of Radiology, The Third Affiliated Hospital of Zhengzhou UniversityDepartment of Radiology, The Third Affiliated Hospital of Zhengzhou UniversityAbstract There is increasing evidence of abnormal neurodevelopmental outcomes in preterm infants with low-grade intraventricular hemorrhage (IVH). The purpose of the study was to explore whether brain microstructure and volume are associated with neuro-behavioral outcomes at 40 weeks corrected gestational age in preterm infants with low-grade IVH. MR imaging at term-equivalent age (TEA) was performed in 25 preterm infants with mild IVH (Papile grading I/II) and 40 control subjects without IVH. These subjects all had neonatal behavioral neurological assessment (NBNA) at 40 weeks’ corrected age. Microstructure and volume evaluation of the brain were performed by using diffusion kurtosis imaging (DKI) and Synthetic MRI. Correlations among microstructure parameters, volume, and developmental outcomes were explored by using Spearman's correlation. In preterm infants with low-grade IVH, the volume of brain parenchymal fraction (BPF) was reduced. In addition, mean kurtosis (MK), fractional anisotropy (FA), radial kurtosis (RK), axial kurtosis (AK) in several major brain regions were reduced, while mean diffusivity (MD) was increased (P < 0.05). BPF, RK in the cerebellum, MK in the genu of the corpus callosum, and MK in the thalamus of preterm infants with low-grade IVH were associated with lower NBNA scores (r = 0.831, 0.836, 0.728, 0.772, P < 0.05). DKI and Synthetic MRI can quantitatively evaluate the microstructure alterations and brain volumes in preterm infants with low-grade IVH, which provides clinicians with a more comprehensive and accurate neurobehavioral assessment of preterm infants with low-grade IVH.https://doi.org/10.1038/s41598-024-56148-5Low-grade intraventricular hemorrhagePreterm InfantsDiffusion kurtosis imagingSynthetic MRINeurodevelopment |
| spellingShingle | Chunxiang Zhang Zitao Zhu Kaiyu Wang Brianna F. Moon Bohao Zhang Yanyong Shen Zihe Wang Xin Zhao Xiaoan Zhang Assessment of brain structure and volume reveals neurodevelopmental abnormalities in preterm infants with low-grade intraventricular hemorrhage Scientific Reports Low-grade intraventricular hemorrhage Preterm Infants Diffusion kurtosis imaging Synthetic MRI Neurodevelopment |
| title | Assessment of brain structure and volume reveals neurodevelopmental abnormalities in preterm infants with low-grade intraventricular hemorrhage |
| title_full | Assessment of brain structure and volume reveals neurodevelopmental abnormalities in preterm infants with low-grade intraventricular hemorrhage |
| title_fullStr | Assessment of brain structure and volume reveals neurodevelopmental abnormalities in preterm infants with low-grade intraventricular hemorrhage |
| title_full_unstemmed | Assessment of brain structure and volume reveals neurodevelopmental abnormalities in preterm infants with low-grade intraventricular hemorrhage |
| title_short | Assessment of brain structure and volume reveals neurodevelopmental abnormalities in preterm infants with low-grade intraventricular hemorrhage |
| title_sort | assessment of brain structure and volume reveals neurodevelopmental abnormalities in preterm infants with low grade intraventricular hemorrhage |
| topic | Low-grade intraventricular hemorrhage Preterm Infants Diffusion kurtosis imaging Synthetic MRI Neurodevelopment |
| url | https://doi.org/10.1038/s41598-024-56148-5 |
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