Outbreak of occupational Brucella infection caused by live attenuated Brucella vaccine in a biological products company in Chongqing, China, 2020
The northern areas of China are traditional endemic regions for brucellosis in both animals and humans, while occasional outbreaks of brucellosis have been observed in neglected southern provinces. On 16 December 2020, Chongqing Center for Disease Control and Prevention (CQCDC) received a report of...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2022-12-01
|
| Series: | Emerging Microbes and Infections |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2022.2130099 |
| _version_ | 1797989539260661760 |
|---|---|
| author | Chunbei Zhou Wenli Huang Xu Xiang Jianping Qiu Dayong Xiao Ning Yao Qiang Shu Shuang Zhou |
| author_facet | Chunbei Zhou Wenli Huang Xu Xiang Jianping Qiu Dayong Xiao Ning Yao Qiang Shu Shuang Zhou |
| author_sort | Chunbei Zhou |
| collection | DOAJ |
| description | The northern areas of China are traditional endemic regions for brucellosis in both animals and humans, while occasional outbreaks of brucellosis have been observed in neglected southern provinces. On 16 December 2020, Chongqing Center for Disease Control and Prevention (CQCDC) received a report of 15 Brucella seropositive employees in a biological products company. The CQCDC and the local health administrative department launched an investigation that included identification of cases, laboratory testing of samples, and employees’ interview to identify the cause of this incident. A case-control study was implemented to compare high-risk factors between cases and serology-negative personals. Human and animal serum samples and environmental swabs were collected for testing. A total of 61 recessive infectors were found with an infection rate of 43.57% (61/140). Fisher’s exact test showed that there were significant differences in Brucella infection rates among different post classifications (p = 0.02), working places (p = 0.007), and buildings (p < 0.0001). Case-control study showed that working in vaccine production workshop was independently associated with an increased risk of infection (odds ratio (OR): 2.60; 95% confidence interval (CI): 1.31–5.19). The positive detection rate was 88.06% (59/67) for production environment and 16.67% (2/12) for external environment. The investigation indicated that close contact with biological products and aerosol were the potential transmission routes of this outbreak under the condition of insufficient personal protection and disinfection. Our study provides new epidemiological evidence for a more detailed understanding of occupational infections with live attenuated Brucella vaccine. |
| first_indexed | 2024-04-11T08:22:01Z |
| format | Article |
| id | doaj.art-09ac7d85f57448059ef1e8961069bfd1 |
| institution | Directory Open Access Journal |
| issn | 2222-1751 |
| language | English |
| last_indexed | 2024-04-11T08:22:01Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj.art-09ac7d85f57448059ef1e8961069bfd12022-12-22T04:34:54ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512022-12-011112544255210.1080/22221751.2022.2130099Outbreak of occupational Brucella infection caused by live attenuated Brucella vaccine in a biological products company in Chongqing, China, 2020Chunbei Zhou0Wenli Huang1Xu Xiang2Jianping Qiu3Dayong Xiao4Ning Yao5Qiang Shu6Shuang Zhou7Chongqing Center for Disease Control and Prevention, Chongqing, People’s Republic of ChinaChongqing Center for Disease Control and Prevention, Chongqing, People’s Republic of ChinaChongqing Center for Disease Control and Prevention, Chongqing, People’s Republic of ChinaRongchang District Center for Disease Control and Prevention, Chongqing, People’s Republic of ChinaChongqing Center for Disease Control and Prevention, Chongqing, People’s Republic of ChinaChongqing Center for Disease Control and Prevention, Chongqing, People’s Republic of ChinaRongchang District Center for Disease Control and Prevention, Chongqing, People’s Republic of ChinaChongqing Center for Disease Control and Prevention, Chongqing, People’s Republic of ChinaThe northern areas of China are traditional endemic regions for brucellosis in both animals and humans, while occasional outbreaks of brucellosis have been observed in neglected southern provinces. On 16 December 2020, Chongqing Center for Disease Control and Prevention (CQCDC) received a report of 15 Brucella seropositive employees in a biological products company. The CQCDC and the local health administrative department launched an investigation that included identification of cases, laboratory testing of samples, and employees’ interview to identify the cause of this incident. A case-control study was implemented to compare high-risk factors between cases and serology-negative personals. Human and animal serum samples and environmental swabs were collected for testing. A total of 61 recessive infectors were found with an infection rate of 43.57% (61/140). Fisher’s exact test showed that there were significant differences in Brucella infection rates among different post classifications (p = 0.02), working places (p = 0.007), and buildings (p < 0.0001). Case-control study showed that working in vaccine production workshop was independently associated with an increased risk of infection (odds ratio (OR): 2.60; 95% confidence interval (CI): 1.31–5.19). The positive detection rate was 88.06% (59/67) for production environment and 16.67% (2/12) for external environment. The investigation indicated that close contact with biological products and aerosol were the potential transmission routes of this outbreak under the condition of insufficient personal protection and disinfection. Our study provides new epidemiological evidence for a more detailed understanding of occupational infections with live attenuated Brucella vaccine.https://www.tandfonline.com/doi/10.1080/22221751.2022.2130099Brucellabrucellosisoutbreakcase-control studyvaccine |
| spellingShingle | Chunbei Zhou Wenli Huang Xu Xiang Jianping Qiu Dayong Xiao Ning Yao Qiang Shu Shuang Zhou Outbreak of occupational Brucella infection caused by live attenuated Brucella vaccine in a biological products company in Chongqing, China, 2020 Emerging Microbes and Infections Brucella brucellosis outbreak case-control study vaccine |
| title | Outbreak of occupational Brucella infection caused by live attenuated Brucella vaccine in a biological products company in Chongqing, China, 2020 |
| title_full | Outbreak of occupational Brucella infection caused by live attenuated Brucella vaccine in a biological products company in Chongqing, China, 2020 |
| title_fullStr | Outbreak of occupational Brucella infection caused by live attenuated Brucella vaccine in a biological products company in Chongqing, China, 2020 |
| title_full_unstemmed | Outbreak of occupational Brucella infection caused by live attenuated Brucella vaccine in a biological products company in Chongqing, China, 2020 |
| title_short | Outbreak of occupational Brucella infection caused by live attenuated Brucella vaccine in a biological products company in Chongqing, China, 2020 |
| title_sort | outbreak of occupational brucella infection caused by live attenuated brucella vaccine in a biological products company in chongqing china 2020 |
| topic | Brucella brucellosis outbreak case-control study vaccine |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2022.2130099 |
| work_keys_str_mv | AT chunbeizhou outbreakofoccupationalbrucellainfectioncausedbyliveattenuatedbrucellavaccineinabiologicalproductscompanyinchongqingchina2020 AT wenlihuang outbreakofoccupationalbrucellainfectioncausedbyliveattenuatedbrucellavaccineinabiologicalproductscompanyinchongqingchina2020 AT xuxiang outbreakofoccupationalbrucellainfectioncausedbyliveattenuatedbrucellavaccineinabiologicalproductscompanyinchongqingchina2020 AT jianpingqiu outbreakofoccupationalbrucellainfectioncausedbyliveattenuatedbrucellavaccineinabiologicalproductscompanyinchongqingchina2020 AT dayongxiao outbreakofoccupationalbrucellainfectioncausedbyliveattenuatedbrucellavaccineinabiologicalproductscompanyinchongqingchina2020 AT ningyao outbreakofoccupationalbrucellainfectioncausedbyliveattenuatedbrucellavaccineinabiologicalproductscompanyinchongqingchina2020 AT qiangshu outbreakofoccupationalbrucellainfectioncausedbyliveattenuatedbrucellavaccineinabiologicalproductscompanyinchongqingchina2020 AT shuangzhou outbreakofoccupationalbrucellainfectioncausedbyliveattenuatedbrucellavaccineinabiologicalproductscompanyinchongqingchina2020 |